DNA damage induced by shikonin in the presence of Cu(II) ions: Potential mechanism of its activity to apoptotic cell death

Journal of Asian Natural Products Research

Volumn 13, Issue 1, 2011, Pages 12-19

  Cheng, Hong Ming ^a   Qiu, Ying Kun ^a   Wu, Zhen ^a   Zhao, Yu Fen ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

apoptosis; Cu(II) reduction; DNA cleavage; reactive oxygen species; shikonin

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; BENZOIC ACID; CALCIUM ION; CATALASE; COBALT; CUPRIC ION; FERROUS ION; MAGNESIUM ION; NICKEL; PLASMID DNA; POTASSIUM IODIDE; REACTIVE OXYGEN METABOLITE; SHIKONIN; SODIUM AZIDE; SUPEROXIDE DISMUTASE; THIOUREA; ZINC ION;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; DNA DEGRADATION; DNA STRAND BREAKAGE; DNA SUPERCOILING; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; HELA CELL; HUMAN; HUMAN CELL;

APOPTOSIS; COPPER; DNA DAMAGE; DRUGS, CHINESE HERBAL; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OXIDATION-REDUCTION; PLASMIDS; REACTIVE OXYGEN SPECIES;

EID: 79251482173     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2010.537262     Document Type: Article

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