Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans

Journal of Applied Physiology

Volumn 110, Issue 1, 2011, Pages 137-141

  Christensen, Britt ^a,b   Dandanell, Sune ^a,c   Kjaer, Michael ^a   Langberg, Henning ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY COLLEGE COPENHAGEN   (Denmark)

Author keywords

Inflammation; NSAID; Type I collagen

Indexed keywords

COLLAGEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2;

ADULT; ARTICLE; BIOSYNTHESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDURANCE; FEMALE; HUMAN; MALE; METABOLISM; PATELLA LIGAMENT; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RUNNING; UPREGULATION;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLLAGEN; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INDOMETHACIN; MALE; PATELLAR LIGAMENT; PHYSICAL ENDURANCE; RUNNING; UP-REGULATION;

EID: 79251476286     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00942.2010     Document Type: Article

References (39)

1. Abrahamsson SO, Lohmander S. Differential effects of insulin-like growth factor-I on matrix and DNA synthesis in various regions and types of rabbit tendons. J Orthop Res 14: 370-376, 1996.
2. Alfredson H. The chronic painful Achilles and patellar tendon: research on basic biology and treatment. Scand J Med Sci Sports 15: 252-259, 2005.
3. Almekinders LC. The efficacy of nonsteroidal anti-inflammatory drugs in the treatment of ligament injuries. Sports Med 9: 137-142, 1990.
4. Almekinders LC, Baynes AJ, Bracey LW. An in vitro investigation into the effects of repetitive motion and nonsteroidal anti-inflammatory medication on human tendon fibroblasts. Am J Sports Med 23: 119-123, 1995.
5. Banes AJ, Tsuzaki M, Hu P, Brigman B, Brown T, Almekinders L, Lawrence WT, Fischer T. PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. J Biomech 28: 1505-1513, 1995.
6. Carlstedt CA, Madsen K, Wredmark T. The influence of indomethacin on collagen synthesis during tendon healing in the rabbit. Prostaglandins 32: 353-358, 1986. (Pubitemid 17183336)
7. Cilli F, Khan M, Fu F, Wang JH. Prostaglandin E2 affects proliferation and collagen synthesis by human patellar tendon fibroblasts. Clin J Sport Med 14: 232-236, 2004.
8. Devkota AC, Tsuzaki M, Almekinders LC, Banes AJ, Weinhold PS. Distributing a fixed amount of cyclic loading to tendon explants over longer periods induces greater cellular and mechanical responses. J Orthop Res 25: 1078-1086, 2007.
9. Ferry ST, Dahners LE, Afshari HM, Weinhold PS. The effects of common anti-inflammatory drugs on the healing rat patellar tendon. Am J Sports Med 35: 1326-1333, 2007.
10. Fini ME, Strissel KJ, Girard MT, Mays JW, Rinehart WB. Interleukin 1α mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate. J Biol Chem 269: 11291-11298, 1994.
11. Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc Immunol Rev 12: 6-33, 2006.
12. Forslund C, Bylander B, Aspenberg P. Indomethacin and celecoxib improve tendon healing in rats. Acta Orthop Scand 74: 465-469, 2003.
13. Goodwin JS, Ceuppens JL. Effect of nonsteroidal anti-inflammatory drugs on immune function. Semin Arthritis Rheum 13: 134-143, 1983.
14. Heinemeier K, Langberg H, Olesen JL, Kjaer M. Role of TGF-β1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue. J Appl Physiol 95: 2390-2397, 2003.
15. Huang H, Kamm RD, Lee RT. Cell mechanics and mechanotransduction: pathways, probes, and physiology. Am J Physiol Cell Physiol 287: C1-C11, 2004.
16. Jensen K, Jorgensen S, Johansen L. A metabolic cart for measurement of oxygen uptake during human exercise using inspiratory flow rate. Eur J Appl Physiol 87: 202-206, 2002.
17. Khan MH, Li Z, Wang JH. Repeated exposure of tendon to prostaglandin- E2 leads to localized tendon degeneration. Clin J Sport Med 15: 27-33, 2005.
18. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698, 2004.
19. Langberg H, Bjorn C, Boushel R, Hellsten Y, Kjaer M. Exerciseinduced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans. J Physiol 542: 977-983, 2002.
20. Langberg H, Boushel R, Skovgaard D, Risum N, Kjaer M. Cyclooxygenase- 2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans. J Physiol 551: 683-689, 2003.
21. Langberg H, Olesen JL, Gemmer C, Kjaer M. Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans. J Physiol 542: 985-990, 2002.
22. Langberg H, Rosendal L, Kjaer M. Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans. J Physiol 534: 297-302, 2001.
23. Langberg H, Skovgaard D, Karamouzis M, Bulow J, Kjaer M. Metabolism and inflammatory mediators in the peritendinous space measured by microdialysis during intermittent isometric exercise in humans. J Physiol 515: 919-927, 1999.
24. Langberg H, Skovgaard D, Petersen LJ, Bulow J, Kjaer M. Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans. J Physiol 521: 299-306, 1999.
25. Li Z, Yang G, Khan M, Stone D, Woo SL, Wang JH. Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching. Am J Sports Med 32: 435-440, 2004.
26. Lonnroth P, Jansson PA, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol Endocrinol Metab 253: E228-E231, 1987.
27. Mackey AL, Kjaer M, Dandanell S, Mikkelsen KH, Holm L, Dossing S, Kadi F, Koskinen SO, Jensen CH, Schroder HD, Langberg H. The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans. J Appl Physiol 103: 425-431, 2007.
28. Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol 6: 262-268, 2010.
29. Matoba H, Gollnick PD. Response of skeletal muscle to training. Sports Med 1: 240-251, 1984.
30. Mikkelsen UR, Helmark IC, Kjaer M, Langberg H. Prostaglandin synthesis can be inhibited locally by infusion of NSAIDS through microdialysis catheters in human skeletal muscle. J Appl Physiol 104: 534-537, 2008.
31. Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol 567: 1021-1033, 2005.
32. Olesen JL, Heinemeier KM, Gemmer C, Kjaer M, Flyvbjerg A, Langberg H. Exercise dependent IGF-I, IGFBPs, and type-I collagen changes in human peritendinous connective tissue determined by microdialysis. J Appl Physiol 102: 214-220, 2007.
33. Orum O, Hansen M, Jensen CH, Sorensen HA, Jensen LB, Horslev- Petersen K, Teisner B. Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone 19: 157-163, 1996.
34. Riley G. The pathogenesis of tendinopathy. A molecular perspective. Rheumatology (Oxford) 43: 131-142, 2004.
35. Riley GP, Cox M, Harrall RL, Clements S, Hazleman BL. Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro. J Hand Surg [Br] 26: 224-228, 2001.
36. Robbins JR, Evanko SP, Vogel KG. Mechanical loading and TGF-β regulate proteoglycan synthesis in tendon. Arch Biochem Biophys 342: 203-211, 1997.
37. Scheller D, Kolb J. The internal reference technique in microdialysis: a practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples. J Neurosci Methods 40: 31-38, 1991.
38. Thampatty BP, Li H, Im HJ, Wang JH. EP4 receptor regulates collagen type-I, MMP-1, and MMP-3 gene expression in human tendon fibroblasts in response to IL-1β treatment. Gene 386: 154-161, 2007.
39. Wang JH, Li Z, Yang G, Khan M. Repetitively stretched tendon fibroblasts produce inflammatory mediators. Clin Orthop Relat Res 243-250, 2004