KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia

International Journal of Hyperthermia

Volumn 27, Issue 1, 2011, Pages 63-73

  Sahin, Emel ^a   Sahin, Mehmet ^a   Sanlioǧlu, Ahter Dilsad ^a   Gümüslü, Saadet ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

apoptosis; caspase 3; hyperthermia; KNK437; PARP; prostate cancer; quercetin; thermotolerance

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; CASPASE 3; HEAT SHOCK PROTEIN 70; KNK 437; MESSENGER RNA; N FORMYL 3,4 METHYLENEDIOXYBENZYLIDENE GAMMA BUTYROLACTAM; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; QUERCETIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; ENZYME ACTIVITY; HEAT TOLERANCE; HYPERTHERMIC THERAPY; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZHYDRYL COMPOUNDS; CASPASE 3; CELL LINE, TUMOR; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPERTHERMIA, INDUCED; MALE; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PYRROLIDINONES; QUERCETIN;

EID: 79251474762     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.3109/02656736.2010.528139     Document Type: Article

References (30)

1. Szasz A, Szasz O, Szasz N. Physical background and technical realization of hyperthermia. In: Baronzio GF and Hager ED, editors. Hyperthermia in cancer treatment: A primer. New York: Springer; 2006. pp 25-57.
2. Roigas J, Wallen ES, Loening SA, Moseley PL. Effects of combined treatment of chemotherapeutics and hyperthermia on survival and the regulation of heat shock proteins in Dunning R3327 prostate carcinoma cells. Prostate 1998;34: 195-202.
3. Koishi M, Yokota S, Mae T, Nishimura Y, Kanamori S, Horii N, Shibuya K, Sasai K, Hiraoka M. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res 2001;7:215-219.
4. Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 2000;92:1564-1572.
5. Samali A, Holmberg CI, Sistonen L, Orrenius S. Thermotolerance and cell death are distinct cellular responses to stress: Dependence on heat shock proteins. FEBS Lett 1999;461:306-310.
6. Jakubowicz-Gil J, Rzymowska J, Gawron A. Quercetin, apoptosis, heat shock. Biochem Pharmacol 2002;64: 1591-1595.
7. Elia G, Santoro MG Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem J 1994;300:201-209.
8. Jones EL, Zhao MJ, Stevenson MA, Calderwood SK. The 70kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia 2004;20:835-849.
9. Larocca LM, Ranelletti FO, Maggiano N, Rutella S, La Barbera EO, Rumi C, Serra F, Voso MT, Piantelli M, Teofili L, et al. Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: Role of heat-shock protein-70. Int J Cancer 1997;73:75-83.
10. Nakanoma T, Ueno M, Iida M, Hirata R, Deguchi N. Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells. Int J Urol 2001;8:623-630.
11. Wachsberger PR, Burd R, Bhala A, Bobyock SB, Wahl ML, Owen CS, Rifat SB, Leeper DB. Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia. Int J Hyperthermia 2003;19:507-519.
12. Piantelli M, Tatone D, Castrilli G, Savini F, Maggiano N, Larocca LM, Ranelletti FO, Natali PG. Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia. Melanoma Res 2001;11:469-476.
13. Kudo M, Naito Z, Yokoyama M, Asano G Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. Exp Mol Pathol 1999;66:66-75.
14. Yokota S, Kitahara M, Nagata K. Benzylidene lactam com-pound, KNK437, a novel inhibitor of acquisition of thermo-tolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res 2000;60:2942-2948.
15. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003;304:505-512.
16. Fuller KJ, Issels RD, Slosman DO, Guillet JG, Soussi T, Polla BS. Cancer and the heat shock response. Eur J Cancer 1994;30A:1884-1891.
17. Milani V, Lorenz M, Weinkauf M, Rieken M, Pastore A, Dreyling M, Issels R. Combination of hyperthermia and bortezomib results in additive killing in mantle cell lymphoma cells. Int J Hyperthermia 2009;25:262-272.
18. Lloyd SN, Chalmers D, Leake RE, Kirk D. Local hyperther-mia for prostatic disease: In vitro studies on human prostatic cancer cell lines. Br J Urol 1992;70:529-533.
19. Karlseder J, Wissing D, Holzer G, Orel L, Sliutz G, Auer H, Jaattela M, Simon MM. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochem Biophys Res Commun 1996;220:153-159.
20. Hosokawa N, Hirayoshi K, Kudo H, Takechi H, Aoike A, Kawai K, Nagata K. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol Cell Biol 1992;12:3490-3498.
21. Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. Embo J 1998;17:6124-6134.
22. Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the APAF-1 apoptosome. Nat Cell Biol 2000;2:469-475.
23. Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger JM, Garrido C, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001;3:839-843.
24. Nonaka T, Akimoto T, Mitsuhashi N, Tamaki Y, Yokota S, Nakano T. Changes in the localization of heat shock protein 72 correlated with development of thermotolerance in human esophageal cancer cell line. Anticancer Res 2003;23: 4677-4687.
25. Ohnishi K, Takahashi A, Yokota S, Ohnishi T. Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status. Int J Radiat Biol 2004;80:607-614.
26. Hansen RK, Oesterreich S, Lemieux P, Sarge KD, Fuqua SA. Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. Biochem Biophys Res Commun 1997;239:851-856.
27. Nimmanapalli R, Gerbino E, Dalton WS, Gandhi V, Alsina M. Hsp70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma. Br J Haematol 2008;142:551-561.
28. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A. Induction of apoptosis by quercetin: Involvement of heat shock protein. Cancer Res 1994;54:4952-4957.
29. Fujita M, Nagai M, Murata M, Kawakami K, Irino S, Takahara J. Synergistic cytotoxic effect of quercetin and heat treatment in a lymphoid cell line (OZ) with low HSP70 expression. Leuk Res 1997;21:139-145.
30. Adachi S, Kokura S, Okayama T, Ishikawa T, Takagi T, Handa O, Naito Y, Yoshikawa T. Effect of hyperthermia combined with gemcitabine on apoptotic cell death in cultured human pancreatic cancer cell lines. Int J Hyperthermia 2009;25:210-219.