Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: Formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening

Drug Metabolism and Disposition

Volumn 39, Issue 2, 2011, Pages 302-311

  Yu, Jian ^a   Folmer, James J ^a   Hoesch, Valerie ^a   Doherty, James ^a   Campbell, James B ^a   Burdette, Doug ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; ACROLEIN DERIVATIVE; CARBON; CARBON 13; CYTOCHROME P450; ENZYME; FORMALDEHYDE; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE; ISOXAZOLE; LEFLUNOMIDE; METHANOL; N [[2 ISOPROPYL 7 METHYL 1 OXOISOINDOLIN 5 YL]METHYL]ISOXAZOLE 5 CARBOXAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM HYDROXIDE; TERIFLUNOMIDE; THIOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; ATOM; BIOTRANSFORMATION; CATALYSIS; ELECTRON; HUMAN; LIVER MICROSOME; MOLECULE; PRIORITY JOURNAL; RING OPENING; SAMPLE;

ACROLEIN; BIOTRANSFORMATION; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HUMANS; ISOXAZOLES; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE;

EID: 79251471464     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.036285     Document Type: Article

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