Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells

Journal of Physiology and Pharmacology

Volumn 61, Issue 6, 2010, Pages 671-677

  Kapatou, E ^a   Skyrlas, A ^a   Agelaki, M G ^a   Pantos, C ^b   Kolettis, T M ^a   Malamou Mitsi, V ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Alveolar epithelial cells; Amiodarone; Apoptosis; Phosphatidylinositol (4 5) bisphosphate; Phospholipidosis; Pulmonary toxicity

Indexed keywords

AMIODARONE; CASPASE 3; CASPASE 8; FLICE INHIBITORY PROTEIN; PHOSPHOLIPASE C GAMMA1; PROTEIN BCL 2; SURVIVIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; ENZYME ACTIVATION; FEMALE; IMMUNOHISTOCHEMISTRY; LIPIDOSIS; LUNG ALVEOLUS EPITHELIUM; LUNG TOXICITY; MOLECULAR DYNAMICS; NICK END LABELING; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

AMIODARONE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CASPASE 8; EPITHELIAL CELLS; FEMALE; IN SITU NICK-END LABELING; LIPIDOSES; LUNG; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C GAMMA; PHOSPHOLIPIDS; PULMONARY ALVEOLI; RATS; RATS, WISTAR;

EID: 79251470134     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Doyle JF, Ho KM. Benefits and risks of long-term amiodarone therapy for persistent atrial fibrillation: a meta-analysis. Mayo Clin Proc 2009; 84: 234-242.
2. Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials. Amiodarone Trials Meta-Analysis Investigators. Lancet 1997; 350: 1417-1424.
3. Lloyd-Jones DM, Wang TJ, Leip EP, et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004; 110: 1042-1046.
4. Ernawati DK, Stafford L, Hughes JD. Amiodarone-induced pulmonary toxicity. Br J Clin Pharmacol 2008; 66: 82-87.
5. Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED. Amiodarone: review of pulmonary effects and toxicity. Drug Saf 2010; 33: 539-558.
6. Reasor MJ, Kacew S. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity. Proc Soc Exp Biol Med 1996; 212: 297-304.
7. Wilson BD, Lippmann ML. Pulmonary accumulation of amiodarone and N-desethylamiodarone. Relationship to the development of pulmonary toxicity. Am Rev Respir Dis 1990; 141: 1553-1558.
8. Seki S, Itagaki S, Kobayashi M, Hirano T, Iseki K. Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line. Biol Pharm Bull 2008; 31: 1449-1452.
9. Sunderji R, Kanji Z, Gin K. Pulmonary effects of low dose amiodarone: a review of the risks and recommendations for surveillance. Can J Cardiol 2000; 16: 1435-1440.
10. Camus P, Jeannin L. Re: Speculation on the mechanism for amiodarone-induced pneumonitis. Radiology 1984; 150: 279-280.
11. Reasor MJ, Kacew S. Drug-induced phospholipidosis: are there functional consequences? Exp Biol Med (Maywood) 2001; 226: 825-830.
12. Yano T, Itoh Y, Yamada M, Egashira N, Oishi R. Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells. Apoptosis 2008; 13: 543-552.
13. Woodle ES, Kulkarni S. Programmed cell death. Transplantation 1998; 66: 681-691.
14. Bolt MW, Card JW, Racz WJ, Brien JF, Massey TE. Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity. J Pharmacol Exp Ther 2001; 298: 1280-1289.
15. Choi IS, Kim BS, Cho KS, et al. Amiodarone induces apoptosis in L-132 human lung epithelial cell line. Toxicol Lett 2002; 132: 47-55.
16. Bargout R, Jankov A, Dincer E, et al. Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 2000; 278: L1039-L1044.
17. Halliwell WH. Cationic amphiphilic drug-induced phospholipidosis. Toxicol Pathol 1997; 25: 53-60.
18. Manzoli L, Martelli AM, Billi AM, Faenza I, Fiume R, Cocco L. Nuclear phospholipase C: involvement in signal transduction. Prog Lipid Res 2005; 44: 185-206.
19. Wilson BD, Clarkson CE, Lippmann ML. Amiodarone causes decreased cell-mediated immune responses and inhibits the phospholipase C signaling pathway. Lung 1993; 171: 137-148.
20. Agelaki MG, Pantos C, Korantzopoulos P, et al. Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats. Eur J Pharmacol 2007; 564: 150-157.
21. Pantos C, Mourouzis I, Delbruyere M, et al. Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart. Eur J Pharmacol 2002; 444: 191-196.
22. Uhal BD, Wang R, Laukka J, Zhuang J, Soledad-Conrad V, Filippatos G. Inhibition of amiodarone-induced lung fibrosis but not alveolitis by angiotensin system antagonists. Pharmacol Toxicol 2003; 92: 81-87.
23. Kaczmarek M, Frydrychowicz M, Nowicka A, et al. Influence of pleural macrophages on proliferative activity and apoptosis regulating proteins of malignant cells. J Physiol Pharmacol 2008; 59(Suppl 6): 321-330.
24. Park S, Kim JA, Choi S, Suh SH. Superoxide is a potential culprit of caspase-3 dependent endothelial cell death induced by lysophosphatidylcholine. J Physiol Pharmacol 2010; 61: 375-381.
25. Lullmann H, Lullmann-Rauch R, Wassermann O. Lipidosis induced by amphiphilic cationic drugs. Biochem Pharmacol 1978; 27: 1103-1108.
26. Hostetler KY, Reasor MJ, Walker ER, Yazaki PJ, Frazee BW. Role of phospholipase A inhibition in amiodarone pulmonary toxicity in rats. Biochim Biophys Acta 1986; 875: 400-405.
27. Martin WJ, 2nd, Kachel DL, Vilen T, Natarajan V. Mechanism of phospholipidosis in amiodarone pulmonary toxicity. J Pharmacol Exp Ther 1989; 251: 272-278.
28. Kodavanti UP, Mehendale HM. Amiodarone- and desethylamiodarone-induced pulmonary phospholipidosis, inhibition of phospholipases in vivo, and alteration of [14C]amiodarone uptake by perfused lung. Am J Respir Cell Mol Biol 1991; 4: 369-378.
29. Blake TL, Reasor MJ. Pulmonary responses to amiodarone in hamsters: comparison of intratracheal and oral administrations. Toxicol Appl Pharmacol 1995; 131: 325-331.
30. Heath MF, Costa-Jussa FR, Jacobs JM, Jacobson W. The induction of pulmonary phospholipidosis and the inhibition of lysosomal phospholipases by amiodarone. Br J Exp Pathol 1985; 66: 391-397.
31. Le Bouter S, El Harchi A, Marionneau C, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation 2004; 110: 3028-3035.
32. Piccotti JR, LaGattuta MS, Knight SA, Gonzales AJ, Bleavins MR. Induction of apoptosis by cationic amphiphilic drugs amiodarone and imipramine. Drug Chem Toxicol 2005; 28: 117-133.
33. Lemasters JJ, Nieminen AL, Qian T, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998; 1366: 177-196.
34. Deng X, Ruvolo P, Carr B, May WS, Jr. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci USA 2000; 97: 1578-1583.
35. Ito T, Deng X, Carr B, May WS. Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 1997; 272: 11671-11673.