Expression of trophic peptides and their receptors in chromaffin cells and pheochromocytoma

Cellular and Molecular Neurobiology

Volumn 30, Issue 8, 2010, Pages 1383-1389

  Thouënnon, Erwan ^a,b   Pierre, Alice ^a   Yon, Laurent ^a   Anouar, Youssef ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Chromaffin cells; Malignancy; Pheochromocytomas; Trophic peptides; Tumorigenesis

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN RECEPTOR; CELL PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; TROPHIC PEPTIDE; TROPHIC PEPTIDE RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; AUTOCRINE EFFECT; CARCINOGENESIS; CATECHOLAMINE METABOLISM; CATECHOLAMINE RELEASE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CHROMAFFIN CELL; CONFERENCE PAPER; HUMAN; NONHUMAN; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REGULATORY MECHANISM;

ADRENAL GLAND NEOPLASMS; ANIMALS; CHROMAFFIN CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEUROPEPTIDES; PHEOCHROMOCYTOMA; RECEPTORS, NEUROPEPTIDE;

EID: 79151479959     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-010-9594-9     Document Type: Conference Paper

References (70)

1. JM Allen TE Adrian JM Polak SR Bloom 1983 Neuropeptide Y (NPY) in the adrenal gland J Auton Nerv Syst 9 559 563 1:CAS:528:DyaL2cXhtlartL0%3D 10.1016/0165-1838(83)90013-9 6689331
2. DJ Autelitano 1998 Cardiac expression of genes encoding putative adrenomedullin/calcitonin gene-related peptide receptors Biochem Biophys Res Commun 250 689 693 1:CAS:528:DyaK1cXmsF2qsLs%3D 10.1006/bbrc.1998.9375 9784407
3. DJ Autelitano F Tang 1999 Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle Clin Sci 96 493 498 1:CAS:528:DyaK1MXjslSrsLg%3D 10.1042/CS19980311 10209081
4. K Babinski V Bodart M Roy A De Lean H Ong 1996 Pituitary adenylate-cyclase activating polypeptide (PACAP) evokes long-lasting secretion and de novo biosynthesis of bovine adrenal medullary neuropeptides Neuropeptides 30 572 582 1:CAS:528:DyaK2sXlsFantw%3D%3D 10.1016/S0143-4179(96)90041-4 9004256
5. CC Bleul M Farzan H Choe C Parolin I Clark-Lewis J Sodroski TA Springer 1996 The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry Nature 382 829 833 1:CAS:528:DyaK28XltlWqs7k%3D 10.1038/382829a0 8752280
6. L Breault L Yon M Montero L Chouinard V Contesse C Delarue A Fournier JG Lehoux H Vaudry N Gallo-Payet 2000 Occurrence and effect of PACAP in the human fetal adrenal gland Ann N Y Acad Sci 921 429 433 1:CAS:528: DC%2BD3MXntVarsA%3D%3D 10.1111/j.1749-6632.2000.tb07010.x 11193870
7. C Cavadas AP Silva F Mosimann MD Cotrim CA Ribeiro HR Brunner E Grouzmann 2001 NPY regulates catecholamine secretion from human adrenal chromaffin cells J Clin Endocrinol Metab 86 5956 5963 1:CAS:528:DC%2BD3MXptVyksL4%3D 10.1210/jc.86.12.5956 11739470
8. C Cavadas D Cefai J Rosmaninho-Salgado MA Vieira-Coelho E Moura N Busso T Pedrazzini D Grand S Rotman B Waeber JF Aubert E Grouzmann 2006 Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion Proc Natl Acad Sci USA 103 10497 10502 1:CAS:528:DC%2BD28XnsVShsLk%3D 10.1073/pnas.0600913103 16798884
9. S Cleary JK Phillips TT Huynh K Pacak AG Elkahloun J Barb RA Worrell DS Goldstein G Eisenhofer 2007 Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome J Endocrinol 193 225 233 1:CAS:528:DC%2BD2sXlvFKkurw%3D 10.1677/JOE-06-0138 17470513
10. ME de Quidt PC Emson 1986 Neuropeptide Y in the adrenal gland: characterization, distribution and drug effects Neuroscience 19 1011 1022 10.1016/0306-4522(86)90313-1 3540720
11. A Dejda V Jolivel S Bourgault T Seaborn A Fournier H Vaudry D Vaudry 2008 Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases J Mol Neurosci 36 26 37 1:CAS:528:DC%2BD1cXhsVagtLjM 10.1007/s12031-008-9087-1 18506634
12. P deS Senanayake J Denker EL Bravo RM Graham 1995 Production, characterization, and expression of neuropeptide Y by human pheochromocytoma J Clin Invest 96 2503 2509 1:STN:280:DyaK28%2Fms1Ohsg%3D%3D 10.1172/JCI118310 7593641
13. Y Dumont R Quirion 2006 An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization EXS 95 7 33 1:CAS:528: DC%2BD28XktFyqtw%3D%3D 16382995
14. L Edvinsson P Emson J McCulloch K Tatemoto R Uddman 1983 Neuropeptide Y: cerebrovascular innervation and vasomotor effects in the cat Neurosci Lett 43 79 84 1:CAS:528:DyaL2cXpsleqsg%3D%3D 10.1016/0304-3940(83)90132-5 6689442
15. J Fahrenkrug T Buhl J Hannibal 1995 PreproPACAP-derived peptides occur in VIP-producing tumours and co-exist with VIP Regul Pept 58 89 98 1:CAS:528:DyaK2MXns1Gls7w%3D 10.1016/0167-0115(95)00052-D 8577931
16. SO Fetissov J Kopp T Hokfelt 2004 Distribution of NPY receptors in the hypothalamus Neuropeptides 38 175 188 1:CAS:528:DC%2BD2cXntVOjsLc%3D 10.1016/j.npep.2004.05.009 15337370
17. MO Garcia-Fernandez G Bodega A Ruiz-Villaespesa J Cortes JC Prieto MJ Carmena 2004 PACAP expression and distribution in human breast cancer and healthy tissue Cancer Lett 205 189 195 1:CAS:528:DC%2BD2cXhsVKitLg%3D 10.1016/j.canlet.2003.10.008 15036651
18. H Ghzili L Grumolato E Thouënnon Y Tanguy V Turquier H Vaudry Y Anouar 2008 Role of PACAP in the physiology and pathology of the sympathoadrenal system Front Neuroendocrinol 29 128 141 1:CAS:528:DC%2BD1cXisFOrsg%3D%3D 18048093
19. E Grouzmann C Gicquel PF Plouin M Schlumberger E Comoy C Bohuon 1990 Neuropeptide Y and neuron-specific enolase levels in benign and malignant pheochromocytomas Cancer 66 1833 1835 1:STN:280:DyaK3M%2Fgtl2jsw%3D%3D 10.1002/1097-0142(19901015)66:8<1833::AID-CNCR2820660831>3.0.CO;2-9 2208039
20. L Grumolato E Louiset D Alexandre D Ait-Ali V Turquier A Fournier A Fasolo H Vaudry Y Anouar 2003 PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells Eur J Neurosci 17 71 82 10.1046/j.1460-9568.2003.02426.x 12534970
21. J Guillemot D Ait-Ali V Turquier M Montero-Hadjadje A Fournier H Vaudry Y Anouar L Yon 2006 Involvement of multiple signaling pathways in PACAP-induced EM66 secretion from chromaffin cells Regul Pept 137 79 88 1:CAS:528: DC%2BD28Xht1ersrvM 10.1016/j.regpep.2006.04.023 16963134
22. J Guillemot D Ait-Ali V Turquier M Montero-Hadjadje A Fournier H Vaudry Y Anouar L Yon 2006 PACAP stimulates the release of the secretogranin II-derived peptide EM66 from chromaffin cells Ann N Y Acad Sci 1070 309 312 1:CAS:528:DC%2BD28XpvVehtL0%3D 10.1196/annals.1317.033 16888183
23. C Hamelink O Tjurmina R Damadzic WS Young E Weihe HW Lee LE Eiden 2002 Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis Proc Natl Acad Sci USA 99 461 466 1:CAS:528:DC%2BD38Xlt1CrsQ%3D%3D 10.1073/pnas.012608999 11756684
24. DE Hansel BA Eipper GV Ronnett 2001 Neuropeptide Y functions as a neuroproliferative factor Nature 410 940 944 1:CAS:528:DC%2BD3MXjt1Krt78%3D 10.1038/35073601 11309620
25. AJ Harmar WJ Sheward CF Morrison B Waser M Gugger JC Reubi 2004 Distribution of the VPAC2 receptor in peripheral tissues of the mouse Endocrinology 145 1203 1210 1:CAS:528:DC%2BD2cXhs1Wisb0%3D 10.1210/en.2003-1058 14617572
26. TD Hexum LR Russett 1989 Stimulation of cholinergic receptor mediated secretion from the bovine adrenal medulla by neuropeptide Y Neuropeptides 13 35 41 1:CAS:528:DyaL1MXhtVyqtbo%3D 10.1016/0143-4179(89)90019-X 2922105
27. M Hong S Li A Fournier S St-Pierre G Pelletier 1995 Role of neuropeptide Y in the regulation of tyrosine hydroxylase gene expression in rat adrenal glands Neuroendocrinology 61 85 88 1:CAS:528:DyaK2MXjsFeqtL8%3D 10.1159/000126816 7731501
28. K Isobe I Tatsuno T Yashiro T Nanmoku K Takekoshi Y Kawakami T Nakai 2003 Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis Regul Pept 110 213 217 1:CAS:528:DC%2BD3sXovFCrug%3D%3D 10.1016/S0167-0115(02)00209-4 12573802
29. K Isobe M Kaneko S Kaneko S Nissato T Nanmoku K Takekoshi Y Okuda Y Kawakami 2004 Expression of mRNAs for PACAP and its receptor in human neuroblastomas and their relationship to catecholamine synthesis Regul Pept 123 29 32 1:CAS:528:DC%2BD2cXptFOlt70%3D 10.1016/j.regpep.2004.05.011 15518890
30. K Kitamura K Kangawa M Kawamoto Y Ichiki S Nakamura H Matsuo T Eto 1993 Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma Biochem Biophys Res Commun 192 553 560 1:CAS:528:DyaK3sXksVWktb0%3D 10.1006/bbrc.1993.1451 8387282
31. J Kitlinska 2007 Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization Cancer Lett 245 293 302 1:CAS:528: DC%2BD2sXht1ensg%3D%3D 10.1016/j.canlet.2006.01.010 16513255
32. J Kitlinska K Abe L Kuo J Pons M Yu L Li J Tilan L Everhart EW Lee Z Zukowska JA Toretsky 2005 Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors Cancer Res 65 1719 1728 1:CAS:528:DC%2BD2MXitVOjsLo%3D 10.1158/0008-5472.CAN-04-2192 15753367
33. H Kobayashi R Yamamoto K Kitamura K Kuwasako S Minami T Yanagita S Shiraishi H Yokoo T Eto A Wada 2001 Selective inhibition of nicotinic cholinergic receptors by proadrenomedullin N-terminal 12 peptide in bovine adrenal chromaffin cells Brain Res Mol Brain Res 87 175 183 1:CAS:528: DC%2BD3MXhs1eis7o%3D 10.1016/S0169-328X(01)00011-0 11245919
34. H Kobayashi T Yanagita H Yokoo A Wada 2001 Adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP) in adrenal chromaffin cells Peptides 22 1895 1901 1:CAS:528:DC%2BD3MXptFyksbw%3D 10.1016/S0196-9781(01) 00512-5 11754978
35. H Kobayashi T Yanagita H Yokoo A Wada 2003 Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cells Hypertens Res 26 Suppl S71 S78 10.1291/hypres.26.S71 12630814
36. M Korner B Waser JC Reubi 2004 High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia Clin Cancer Res 10 8426 8433 10.1158/1078-0432.CCR-04-0821 15623622
37. S Lamouche N Yamaguchi 2003 PACAP release from the canine adrenal gland in vivo: its functional role in severe hypotension Am J Physiol Regul Integr Comp Physiol 284 R588 R597 1:CAS:528:DC%2BD3sXhtlOqtL8%3D 12414436
38. D Larhammar E Salaneck 2004 Molecular evolution of NPY receptor subtypes Neuropeptides 38 141 151 1:CAS:528:DC%2BD2cXntVOjsLg%3D 10.1016/j.npep.2004.06. 002 15337367
39. 2+ influx and activation of the serine/threonine phosphatase calcineurin J Neurochem 73 1769 1772 1:CAS:528:DyaK1MXmtlOht78%3D 10.1046/j.1471-4159.1999.731769.x 10501227
40. EW Lee M Michalkiewicz J Kitlinska I Kalezic H Switalska P Yoo A Sangkharat H Ji L Li T Michalkiewicz M Ljubisavljevic H Johansson DS Grant Z Zukowska 2003 Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles J Clin Invest 111 1853 1862 1:CAS:528: DC%2BD3sXkvV2kur8%3D 12813021
41. TM Luke TD Hexum 2008 Tyrosine hydroxylase phosphorylation increases in response to ATP and neuropeptide Y co-stimulation of ERK2 phosphorylation Pharmacol Res 58 52 57 1:CAS:528:DC%2BD1cXhtVygtLbL 10.1016/j.phrs.2008.06.010 18639636
42. LK Malendowicz MT Conconi PP Parnigotto GG Nussdorfer 2003 Endogenous adrenomedullin system regulates the growth of rat adrenocortical cells cultured in vitro Regul Pept 112 27 31 1:CAS:528:DC%2BD3sXitlWrtLY%3D 10.1016/S0167-0115(03)00019-3 12667622
43. K Masada T Nagayama A Hosokawa M Yoshida M Suzuki-Kusaba H Hisa T Kimura S Satoh 1999 Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs Am J Physiol 276 R1118 R1124 1:STN:280:DyaK1M3hs1amsw%3D%3D 10198393
44. G Mazzocchi G Albertin PG Andreis G Neri LK Malendowicz HC Champion M Bahcelioglu PJ Kadowitz GG Nussdorfer 1999 Distribution, functional role, and signaling mechanism of adrenomedullin receptors in the rat adrenal gland Peptides 20 1479 1487 1:CAS:528:DC%2BD3cXosFSksg%3D%3D 10.1016/S0196-9781(99) 00159-X 10698124
45. S McKenzie PD Marley 2002 Caffeine stimulates Ca(2+) entry through store-operated channels to activate tyrosine hydroxylase in bovine chromaffin cells Eur J Neurosci 15 1485 1492 10.1046/j.1460-9568.2002.01990.x 12028358
46. Z Miao KE Luker BC Summers R Berahovich MS Bhojani A Rehemtulla CG Kleer JJ Essner A Nasevicius GD Luker MC Howard TJ Schall 2007 CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature Proc Natl Acad Sci USA 104 15735 15740 1:CAS:528: DC%2BD2sXhtFGns7%2FJ 10.1073/pnas.0610444104 17898181
47. C Moretti C Mammi GV Frajese S Mariani L Gnessi M Arizzi F Wannenes G Frajese 2006 PACAP and type I PACAP receptors in human prostate cancer tissue Ann N Y Acad Sci 1070 440 449 1:CAS:528:DC%2BD28XpvVehurk%3D 10.1196/annals.1317.059 16888207
48. M Nakamura B Han O Nunobiki K Kakudo 2006 Adrenomedullin: a tumor progression factor via angiogenic control Curr Cancer Drug Targets 6 635 643 1:CAS:528:DC%2BD28XhtFSju7zN 10.2174/156800906778742442 17100569
49. HS Nielsen J Hannibal J Fahrenkrug 1998 Prenatal expression of pituitary adenylate cyclase activating polypeptide (PACAP) in autonomic and sensory ganglia and spinal cord of rat embryos Ann N Y Acad Sci 865 533 536 1:CAS:528:DyaK1MXmvFaisQ%3D%3D 10.1111/j.1749-6632.1998.tb11231.x 9928064
50. MM O'Hare TW Schwartz 1989 Expression and precursor processing of neuropeptide Y in human pheochromocytoma and neuroblastoma tumors Cancer Res 49 7010 7014 2582442
51. 2+ release from a cAMP-dependent pool in human fetal adrenal gland chromaffin cells J Biol Chem 278 1663 1670 1:CAS:528:DC%2BD3sXisFyguw%3D%3D 10.1074/jbc.M206470200 12429744
52. J Pons J Kitlinska H Ji EW Lee Z Zukowska 2003 Mitogenic actions of neuropeptide Y in vascular smooth muscle cells: synergetic interactions with the beta-adrenergic system Can J Physiol Pharmacol 81 177 185 1:CAS:528: DC%2BD3sXisVCgsb0%3D 10.1139/y02-166 12710532
53. D Renshaw LM Thomson GJ Michael M Carroll S Kapas JP Hinson 2000 Adrenomedullin receptor is found exclusively in noradrenaline-secreting cells of the rat adrenal medulla J Neurochem 74 1766 1772 1:CAS:528:DC%2BD3cXitVens7s%3D 10.1046/j.1471-4159.2000.0741766.x 10737636
54. JC Reubi U Laderach B Waser JO Gebbers P Robberecht JA Laissue 2000 Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin Cancer Res 60 3105 3112 1:CAS:528:DC%2BD3cXjvFOltLc%3D 10850463
55. PM Rose JS Lynch ST Frazier SM Fisher W Chung P Battaglino Z Fathi R Leibel P Fernandes 1997 Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine "Y5" receptor may be a pseudogene J Biol Chem 272 3622 3627 1:CAS:528:DyaK2sXhtFeqsr8%3D 10.1074/jbc.272.6.3622 9013614
56. M Ruscica E Dozio M Motta P Magni 2007 Role of neuropeptide Y and its receptors in the progression of endocrine-related cancer Peptides 28 426 434 1:CAS:528:DC%2BD2sXhtlansL8%3D 10.1016/j.peptides.2006.08.045 17204352
57. K Shimoda GH Shen RF Pfeiffer RD McComb HY Yang 1993 Antiserum against neuropeptide Y enhances the nicotine-mediated release of catecholamines from cultured rat adrenal chromaffin cells Neurochem Int 23 71 77 1:CAS:528:DyaK3sXltV2rsrc%3D 10.1016/0197-0186(93)90145-U 8369734
58. T Shimosawa T Fujita 2005 Adrenomedullin and its related peptide Endocr J 52 1 10 1:CAS:528:DC%2BD2MXjvV2qurw%3D 10.1507/endocrj.52.1 15758552
59. R Spinazzi PG Andreis GG Nussdorfer 2005 Neuropeptide-Y and Y-receptors in the autocrine-paracrine regulation of adrenal gland under physiological and pathophysiological conditions (Review) Int J Mol Med 15 3 13 1:CAS:528:DC%2BD2MXmsFaqtA%3D%3D 15583821
60. K Takahashi K Totsune O Murakami M Sone K Itoi Y Miura T Mouri 1993 Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in pheochromocytomas Peptides 14 365 369 1:CAS:528:DyaK3sXit1Kju70%3D 10.1016/0196-9781(93)90054-K 8483815
61. K Tatemoto M Carlquist V Mutt 1982 Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide Nature 296 659 660 1:CAS:528:DyaL38XlsFKlt78%3D 10.1038/296659a0 6896083
62. E Thouënnon AG Elkahloun J Guillemot AP Gimenez-Roqueplo J Bertherat A Pierre H Ghzili L Grumolato M Muresan M Klein H Lefebvre L Ouafik H Vaudry PF Plouin L Yon Y Anouar 2007 Identification of potential gene markers and insights into the pathophysiology of pheochromocytoma malignancy J Clin Endocrinol Metab 92 4865 4872 10.1210/jc.2007-1253 17878247
63. E Thouënnon A Pierre Y Tanguy J Guillemot DL Manecka M Guerin L Ouafik M Muresan M Klein J Bertherat H Lefebvre PF Plouin L Yon Y Anouar 2010 Expression of trophic amidated peptides and their receptors in benign and malignant pheochromocytomas: high expression of adrenomedullin RDC1 receptor and implication in tumoral cell survival Endocr Relat Cancer 17 637 651 10.1677/ERC-10-0109 20483910
64. C Tonshoff L Hemmick MJ Evinger 1997 Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells J Mol Neurosci 9 127 140 1:CAS:528:DyaK2sXnvVajs7w%3D 10.1007/BF02736856 9407393
65. B Uzan A Villemin JM Garel M Cressent 2008 Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway J Cell Physiol 215 122 128 1:CAS:528:DC%2BD1cXjt1Cgs7c%3D 10.1002/jcp.21294 17941085
66. D Vaudry A Falluel-Morel S Bourgault M Basille D Burel O Wurtz A Fournier BK Chow H Hashimoto L Galas H Vaudry 2009 Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery Pharmacol Rev 61 283 357 1:CAS:528:DC%2BC3cXhsVWmu7vK 10.1124/pr.109.001370 19805477
67. J Wang Y Shiozawa J Wang Y Wang Y Jung KJ Pienta R Mehra R Loberg RS Taichman 2008 The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer J Biol Chem 283 4283 4294 1:CAS:528:DC%2BD1cXhs1WgtbY%3D 10.1074/jbc.M707465200 18057003
68. L Yon L Breault V Contesse G Bellancourt C Delarue A Fournier JG Lehoux H Vaudry N Gallo-Payet 1998 Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation J Clin Endocrinol Metab 83 1299 1305 1:CAS:528:DyaK1cXitlyntLw%3D 10.1210/jc.83.4.1299 9543159
69. E Zudaire A Martinez F Cuttitta 2003 Adrenomedullin and cancer Regul Pept 112 175 183 1:CAS:528:DC%2BD3sXitlWrurg%3D 10.1016/S0167-0115(03)00037-5 12667640
70. Z Zukowska J Pons EW Lee L Li 2003 Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system? Can J Physiol Pharmacol 81 89 94 1:CAS:528:DC%2BD3sXisVCgsL8%3D 10.1139/y03-006 12710520