Use of dexmedetomidine for sedation in critically ill mechanically ventilated pediatric burn patients

Journal of Burn Care and Research

Volumn 32, Issue 1, 2011, Pages 98-103

  Lin, Hsin ^a   Faraklas, Iris ^a   Sampson, Christopher ^a   Saffle, Jeffrey R ^a   Cochran, Amalia ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; SEDATIVE AGENT;

ADOLESCENT; ARTICLE; ARTIFICIAL VENTILATION; BODY SURFACE; BRADYCARDIA; BURN; CHILD; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; HEART RATE; HUMAN; HYPERTENSION; HYPOTENSION; INTUBATION; LENGTH OF STAY; MALE; PRESCHOOL CHILD; RIKER SCORE; SCHOOL CHILD; SCORING SYSTEM; SEDATION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

ADOLESCENT; BURNS; CHILD; CHILD, PRESCHOOL; CONSCIOUS SEDATION; CRITICAL ILLNESS; DEXMEDETOMIDINE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; INTUBATION, INTRATRACHEAL; LENGTH OF STAY; MALE; PAIN MEASUREMENT; RESPIRATION, ARTIFICIAL; TIME FACTORS;

EID: 79151474494     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e318203332d     Document Type: Article

References (13)

1. Jacobi J, Fraser GL, Cousin DB, et al; Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), American Society of Health-System Pharmacists (ASHP), American College of Chest Physicians. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41. (Pubitemid 34112188)
2. Hartman M, McCrory D, Schulman S. Efficacy of sedation regimens to facilitate mechanical ventilation in the pediatric intensive care unit: a systemic review. Crit Care Med 1994; 22:163-70.
3. Riker R, Shehabi Y, Bokesch P, et al. Dexmedetomidine vs. midazolam for sedation of critically ill patients. JAMA 2009; 301:489-99.
4. Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs. lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 2007;298:2644-53.
5. Gerlach A, Dasta J. Dexmedetomidine: an updated review. Ann Pharmacother 2007;41:245-52.
6. Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha 2 adrenoceptor agonist dexmedetomidine in post surgical sedation in the intensive care unit. J Intensive Care Med 2003;18:29-41.
7. Venn R, Bradshaw C, Spencer R, et al. PreliminaryUKexperiences of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54:1136-42.
8. Walker J, Maccallum M, Fischer C, Kopcha R, Saylors R, McCall J. Sedation using dexmedetomidine in pediatric burn patients. J Burn Care Res 2006;27:206-10.
9. Buck M, Willson D. Use of dexmedetomidine in the pediatric intensive care unit. Pharmacotherapy 2008;28:51-7.
10. Petroz GC, Sikich N, James M, et al. A phase I two center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 2006;105: 1098-110.
11. Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med 2003;18:29-41.
12. Venn RM, Bradshaw C, Spencer R, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54: 1136-42.
13. Dasta J, Kane-Gill S, Pencina M, et al. A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Crit Care Med 2010;38:497-503.