Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (Tropical Sprue) does not change even after successful treatment

Digestive Diseases and Sciences

Volumn 56, Issue 1, 2011, Pages 161-169

  Kumar, Sunil ^a   Ghoshal, Uday C ^a   Jayalakshmi, Kamaiah ^a   Roy, Raja ^a   Misra, Asha ^a   Khetrapal, C L ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Intestinal function; Lactulose mannitol test; Malabsorption syndrome; Small intestinal permeability; Tropical sprue

Indexed keywords

FECES LIPID; FOLIC ACID; LACTULOSE; MANNITOL; TETRACYCLINE; XYLOSE;

ABNORMAL SMALL INTESTINE PERMEABILITY; ADULT; ARTICLE; BACTERIAL OVERGROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FECES ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HYDROGEN BREATH TEST; IDIOPATHIC DISEASE; INTESTINE FLORA; INTESTINE FUNCTION DISORDER; INTESTINE MUCOSA PERMEABILITY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT RESPONSE; TROPICAL SPRUE; URINALYSIS; URINARY EXCRETION; WEIGHT GAIN;

ADOLESCENT; ADULT; BIOPSY; BREATH TESTS; CASE-CONTROL STUDIES; DRUG THERAPY, COMBINATION; DUODENUM; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HUMANS; INTESTINE, SMALL; LACTULOSE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MANNITOL; MIDDLE AGED; PERMEABILITY; SPRUE, TROPICAL; TETRACYCLINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79151471649     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1232-3     Document Type: Article

References (42)

1. UC Ghoshal U Ghoshal A Ayyagari P Ranjan N Krishnani A Misra R Aggarwal S Naik SR Naik 2003 Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time J Gastroenterol Hepatol 18 540 547 10.1046/j.1440-1746.2003.03006.x 12702046
2. Mehta SK, Kamath PS. Tropical sprue: a review (part-I). Indian J Gastroenterol. 1983; 2:20-24 concl.
3. AL Brunetto AD Pearson MF Laker AW Craft 1989 Intestinal permeability tests and integrity of the small intestinal mucosa Arch Dis Child 64 307 308 1:STN:280:DyaL1M7pt1Crtw%3D%3D 10.1136/adc.64.2.307-a 2494954
4. Q Zhou B Zhang G Nicholas Verne 2009 Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome Pain 146 41 46 1:CAS:528:DC%2BD1MXht1GksL3L 10.1016/j.pain.2009.06.017 19595511
5. RC Spiller D Jenkins JP Thornley JM Hebden T Wright M Skinner KR Neal 2000 Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome Gut 47 804 811 1:STN:280: DC%2BD3M%2FmsVCquw%3D%3D 10.1136/gut.47.6.804 11076879
6. JK Marshall M Thabane AX Garg W Clark J Meddings SM Collins 2004 Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario Aliment Pharmacol Ther 20 1317 1322 1:STN:280:DC%2BD2cnjtVyktQ%3D%3D 10.1111/j.1365-2036.2004.02284.x 15606393
7. GR May LR Sutherland JB Meddings 1993 Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 104 1627 1632 1:STN:280:DyaK3s3ntlWktQ%3D%3D 8500719
8. SO Ukabam JR Clamp BT Cooper 1983 Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon Digestion 27 70 74 1:STN:280:DyaL2c%2FivFGrsA%3D%3D 10.1159/000198932 6414866
9. I Bjarnason TJ Peters 1984 In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease Gut 25 145 150 1:STN:280:DyaL2c7gvFKjtw%3D%3D 10.1136/gut.25.2.145 6420242
10. E Quigley 2009 Gut permeability in irritable bowel syndrome: more leaks add to slightly inflamed bowel syndrome conspiracy theory Gastroenterology 137 728 730 10.1053/j.gastro.2009.06.024 19563841
11. K Jayalakshmi UC Ghoshal S Kumar A Misra R Roy CL Khetrapal 2009 Assessment of small intestinal permeability using 1H-NMR spectroscopy J Gastrointestin Liver Dis 18 27 32 19337630
12. GC Cook IS Menzies 1986 Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue) Digestion 33 109 116 1:STN:280:DyaL287jslWisw%3D%3D 10.1159/000199282 3949090
13. M Dastych M Dastych Jr H Novotna J Cihalova 2008 Lactulose/mannitol test and specificity, sensitivity, and area under curve of intestinal permeability parameters in patients with liver cirrhosis and Crohn's disease Dig Dis Sci 53 2789 2792 1:CAS:528:DC%2BD1cXhtVGnsbnO 10.1007/s10620-007-0184-8 18320320
14. Y Zhang B Lee M Thompson R Glass RI Cama D Figueroa R Gilman D Taylor C Stephenson 2000 Lactulose-mannitol intestinal permeability test in children with diarrhea caused by rotavirus and cryptosporidium. Diarrhea working group, Peru J Pediatr Gastroenterol Nutr 31 16 21 1:STN:280:DC%2BD3M7itFCntQ%3D%3D 10.1097/00005176-200007000-00006 10896065
15. MA Cox TH Iqbal BT Cooper KO Lewis 1997 An analytical method for the quantitation of mannitol and disaccharides in serum: a potentially useful technique in measuring small intestinal permeability in vivo Clin Chim Acta 263 197 205 1:CAS:528:DyaK2sXktlCrtbg%3D 10.1016/S0009-8981(97)00058-2 9246424
16. F Dumas C Aussel P Pernet C Martin J Giboudeau 1994 Gas chromatography applied to the lactulose-mannitol intestinal permeability test J Chromatogr B Biomed Appl 654 276 281 1:CAS:528:DyaK2cXjtFymsrw%3D 10.1016/0378-4347(94)00041- 7 8044289
17. P Ranjan UC Ghoshal R Aggarwal R Pandey A Misra S Naik SR Naik 2004 Etiological spectrum of sporadic malabsorption syndrome in northern Indian adults at a tertiary hospital Indian J Gastroenterol 23 94 98 15250566
18. UC Ghoshal U Ghoshal K Das A Misra 2006 Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit time Indian J Gastroenterol 25 6 10 16567886
19. BS Ramakrishna S Venkataraman A Mukhopadhya 2006 Tropical malabsorption Postgrad Med J 82 779 787 1:CAS:528:DC%2BD2sXhsFyqsr0%3D 10.1136/pgmj.2006. 048579 17148698
20. CR Kapadia P Bhat E Jacob SJ Baker 1975 Vitamin B12 absorption-a study of intraluminal events in control subjects and patients with tropical sprue Gut 16 988 993 1:CAS:528:DyaE28XhtVels70%3D 10.1136/gut.16.12.988 3457
21. SK Nath 2005 Tropical sprue Curr Gastroenterol Rep 7 343 349 10.1007/s11894-005-0002-4 16168231
22. AM Preston 2001 Treatment of tropical sprue: the work of Dr. Bailey K. Ashford examined in retrospect P R Health Sci J 20 225 228 1:STN:280: DC%2BD38%2FkvFKltg%3D%3D 11776723
23. A Lo M Guelrud H Essenfeld P Bonis 2007 Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue Gastrointest Endosc 66 377 382 10.1016/j.gie.2007.02.041 17643717
24. FO Akinbami GA Brown AS McNeish 1989 Intestinal permeability as a measure of small intestinal mucosal integrity: correlation with jejunal biopsy Afr J Med Med Sci 18 187 192 1:STN:280:DyaL1MzptVeitA%3D%3D 2551159
25. PG Lunn CA Northrop-Clewes RM Downes 1991 Recent developments in the nutritional management of diarrhoea. 2. Chronic diarrhoea and malnutrition in The Gambia: studies on intestinal permeability Trans R Soc Trop Med Hyg 85 8 11 1:STN:280:DyaK3M3pslOgtw%3D%3D 10.1016/0035-9203(91)90137-N 1906207
26. MM Mathan J Ponniah VI Mathan 1986 Epithelial cell renewal and turnover and relationship to morphologic abnormalities in jejunal mucosa in tropical sprue Dig Dis Sci 31 586 592 1:STN:280:DyaL283hvFKltw%3D%3D 10.1007/BF01318689 3709324
27. M Berant M Khourie IS Menzies 1992 Effect of iron deficiency on small intestinal permeability in infants and young children J Pediatr Gastroenterol Nutr 14 17 20 1:STN:280:DyaK383ktlarsA%3D%3D 10.1097/00005176-199201000-00004 1573506
28. V Di Leo R D'Inca N Diaz-Granado W Fries C Venturi A D'Odorico D Martines GC Sturniolo 2003 Lactulose/mannitol test has high efficacy for excluding organic causes of chronic diarrhea Am J Gastroenterol 98 2245 2252 10.1111/j.1572-0241.2003.07697.x 14572575
29. Ghoshal UC, Park H, Gwee KA. Bugs and irritable bowel syndrome: The good, the bad and the ugly. J Gastroenterol Hepatol. 2010;25:244-251.
30. SO Ukabam BT Cooper 1985 Small intestinal permeability as an indicator of jejunal mucosal recovery in patients with celiac sprue on a gluten-free diet J Clin Gastroenterol 7 232 236 1:STN:280:DyaL2M3mt1Kluw%3D%3D 10.1097/00004836- 198506000-00009 3926862
31. SM Riordan VM Duncombe MC Thomas A Nagree TD Bolin CJ McIver R Williams 2002 Small intestinal bacterial overgrowth, intestinal permeability, and non-alcoholic steatohepatitis Gut 50 136 138 1:STN:280:DC%2BD38%2Fls1ejtA%3D%3D 10.1136/gut.50.1.136-a 11772983
32. TH Morris SH Sorensen J Turkington RM Batt 1994 Diarrhoea and increased intestinal permeability in laboratory beagles associated with proximal small intestinal bacterial overgrowth Lab Anim 28 313 319 1:STN:280: DyaK2M7jtFGitw%3D%3D 10.1258/002367794780745047 7830370
33. Z Hossain T Hirata 2008 Molecular mechanism of intestinal permeability: interaction at tight junctions Mol Biosyst 4 1181 1185 1:CAS:528: DC%2BD1cXhtlOhtb7J 10.1039/b800402a 19396381
34. L Vellenga JM Mouwen JE van Dijk HJ Breukink 1985 Biological and pathological aspects of the mammalian small intestinal permeability to macromolecules Vet Q 7 322 332 1:STN:280:DyaL28%2Fnt1Sitg%3D%3D 4071953
35. ST Ballard JH Hunter AE Taylor 1995 Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium Annu Rev Nutr 15 35 55 1:CAS:528:DyaK2MXntVCjsr4%3D 10.1146/annurev.nu.15.070195. 000343 8527224
36. JL Madara MA Marcial 1984 Structural correlates of intestinal tight-junction permeability Kroc Found Ser 17 77 100 1:STN:280: DyaL2M%2Fot1Wkuw%3D%3D 6392487
37. MA Perry DN Granger 1981 Permeability of intestinal capillaries to small molecules Am J Physiol 241 G24 G30 1:STN:280:DyaL3M3ivFyrug%3D%3D 7246781
38. L Miele V Valenza G La Torre M Montalto G Cammarota R Ricci R Masciana A Forgione ML Gabrieli G Perotti FM Vecchio G Rapaccini G Gasbarrini CP Day A Grieco 2009 Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease Hepatology 49 1877 1887 1:CAS:528: DC%2BD1MXotVCmtb4%3D 10.1002/hep.22848 19291785
39. AG Cummins IA Penttila JT Labrooy TA Robb GP Davidson 1991 Recovery of the small intestine in coeliac disease on a gluten-free diet: changes in intestinal permeability, small bowel morphology and T-cell activity J Gastroenterol Hepatol 6 53 57 1:STN:280:DyaK3MzlsFyhsA%3D%3D 10.1111/j.1440-1746.1991.tb01145.x 1883978
40. L Valentini J Eggers J Ockenga VK Haas S Buhner BM Winklhofer-Roob S Hengstermann B Sinn A Weigel K Norman M Pirlich H Lochs 2009 Association between intestinal tight junction permeability and whole-body electrical resistance in healthy individuals: a hypothesis Nutrition 25 706 714 1:CAS:528: DC%2BD1MXlsVKjsL8%3D 10.1016/j.nut.2008.11.033 19230613
41. J Benjamin GK Makharia V Ahuja M Kalaivani YK Joshi 2008 Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease World J Gastroenterol 14 6 10.3748/wjg.14.1399
42. SC Fleming MS Kapembwa MF Laker GE Levin GE Griffin 1990 Rapid and simultaneous determination of lactulose and mannitol in urine, by HPLC with pulsed amperometric detection, for use in studies of intestinal permeability Clin Chem 36 797 799 1:CAS:528:DyaK3cXkt1Sgs70%3D 2110873