Discussion of a well-designed clinical trial which did not demonstrate effectiveness: UIC center for botanical dietary supplements research study of black cohosh and red clover

Fitoterapia

Volumn 82, Issue 1, 2011, Pages 88-91

  Shulman, Lee P ^a,b   Banuvar, Suzanne ^a,b   Fong, Harry H S ^b   Farnsworth, Norman R ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Black cohosh; Botanical; Hormone; Menopause; Red clover; Vasomotor symptoms

Indexed keywords

ALCOHOL; CIMICIFUGA RACEMOSA EXTRACT; CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; MEDROXYPROGESTERONE ACETATE; PLACEBO; RED CLOVER EXTRACT;

ANORGASMIA; ANXIETY; ARTHRALGIA; CLINICAL EFFECTIVENESS; DEPRESSION; DIET SUPPLEMENTATION; DRUG ACTIVITY; DRUG SAFETY; DYSPAREUNIA; FATIGUE; FEMALE; HOT FLUSH; HUMAN; INSOMNIA; LIBIDO; MENOPAUSE RELATED DISORDER; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHIZOME; SLEEP; VAGINAL DRYNESS;

CIMICIFUGA; CLINICAL TRIALS, PHASE II AS TOPIC; HOT FLASHES; HUMANS; MENOPAUSE; PHYTOTHERAPY; PLANT EXTRACTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT FAILURE; TRIFOLIUM;

CIMICIFUGA DAHURICA; EQUIDAE; TRIFOLIUM PRATENSE;

EID: 79151471045     PISSN: 0367326X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fitote.2010.10.013     Document Type: Review

References (16)

1. F. Kronenberg, and A. Fugh-Berman Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials Ann Intern Med 137 2002 805 813
2. P.M. Maki, L.H. Rubin, and D. Fornelli Effect of botanicals and combined hormone therapy on cognition in postmenopausal women Menopause 16 2009 1167 1177
3. J.E. Roussow, G.L. Anderson, and R.L. Prentice Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial JAMA 288 2002 321 333
4. S. Carlson, N. Peng, J.K. Prasain, and J.M. Wyss Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females Gen Med 5 Suppl A 2008 S76 S90
5. J.T. Garcia, F. Gonzaga, and D. Tan Use of a multibotanical (Nutrafem) for the relief of menopausal vasomotor symptoms: a double-blind, placebo-controlled study Menopause 17 2010 237 238
6. R.B. van Breeman, H.H.S. Fong, and N.R. Farnsworth Ensuring the safety of botanical dietary supplements Am J Clin Nutr 87 suppl 2008 509S 513S
7. A. Maclennan, J. Broadbent, S. Lester, and V. Moore Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes Cochrane Database Syst Rev 2004 CD002978
8. T. Low Dog Menopause: a review of botanical dietary supplements Am J Med 118suppl 12B 2005 98 108
9. S.E. Geller, L.P. Shulman, and R.B. van Breeman Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial Menopause 16 2009 1156 1166
10. Shulman L.P. The menstrual cycle. In: Contraceptive Technology, 20th ed. (Hatcher R, Trussel J, Nelson A, et al, eds). Ardent Media, in press.
11. J.E. Burdette, J. Liu, and S.N. Chen Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor J Agric Food Chem 51 2003 5661 5670
12. H.D. Nelson, K.K. Vesco, and E. Haney Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis JAMA 295 2006 2057 2071
13. S. Lontos, R. Jones, P. Angus, and P. Gow Acute liver failure associated with the use of herbal preparations containing black cohosh Med J Aust 179 2003 390 391
14. G. Mahady, Dog T. Low, and M. Barrett Pharmacopeia review of the black cohosh case reports of hepatotoxicity Menopause 15 2008 628 638
15. W. Abebe Herbal medication: potential for adverse interactions with analgesic drugs J Clin Pharm Ther 27 2002 391 401
16. K. Newton, S. Reed, and A. LaCroix Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial Ann Intern Med 145 2006 869 879