메뉴 건너뛰기




Volumn 90, Issue 2-3, 2011, Pages 270-277

Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation

Author keywords

Alpha 6 beta 4; Epidermis; Epidermolysis bullosa; Hemidesmosome; Inflammation; Integrin; Keratinocyte; Laminin; Plectin; Skin

Indexed keywords

ALPHA6 INTEGRIN; AMPHIREGULIN; EPIREGULIN; LAMININ; LAMININ 111; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 79151469084     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2010.09.003     Document Type: Article
Times cited : (36)

References (26)
  • 1
    • 34547757016 scopus 로고    scopus 로고
    • Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects
    • Ackerl R., Walko G., Fuchs P., Fischer I., Schmuth M., Wiche G. Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects. J Cell Sci 2007, 120:2435-2443.
    • (2007) J Cell Sci , vol.120 , pp. 2435-2443
    • Ackerl, R.1    Walko, G.2    Fuchs, P.3    Fischer, I.4    Schmuth, M.5    Wiche, G.6
  • 2
    • 3042845742 scopus 로고    scopus 로고
    • Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis
    • Cook P.W., Brown J.R., Cornell K.A., Pittelkow M.R. Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp Dermatol 2004, 13:347-356.
    • (2004) Exp Dermatol , vol.13 , pp. 347-356
    • Cook, P.W.1    Brown, J.R.2    Cornell, K.A.3    Pittelkow, M.R.4
  • 4
    • 0032587606 scopus 로고    scopus 로고
    • Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
    • De Arcangelis A., Mark M., Kreidberg J., Sorokin L., Georges-Labouesse E. Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development 1999, 126:3957-3968.
    • (1999) Development , vol.126 , pp. 3957-3968
    • De Arcangelis, A.1    Mark, M.2    Kreidberg, J.3    Sorokin, L.4    Georges-Labouesse, E.5
  • 5
    • 0032715703 scopus 로고    scopus 로고
    • Restricted distribution of laminin alpha1 chain in normal adult mouse tissues
    • Falk M., Ferletta M., Forsberg E., Ekblom P. Restricted distribution of laminin alpha1 chain in normal adult mouse tissues. Matrix Biol 1999, 18:557-568.
    • (1999) Matrix Biol , vol.18 , pp. 557-568
    • Falk, M.1    Ferletta, M.2    Forsberg, E.3    Ekblom, P.4
  • 9
    • 0033571243 scopus 로고    scopus 로고
    • Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
    • Indra A.K., Warot X., Brocard J., Bornert J.M., Xiao J.H., Chambon P., Metzger D. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res 1999, 27:4324-4327.
    • (1999) Nucleic Acids Res , vol.27 , pp. 4324-4327
    • Indra, A.K.1    Warot, X.2    Brocard, J.3    Bornert, J.M.4    Xiao, J.H.5    Chambon, P.6    Metzger, D.7
  • 10
    • 0034609819 scopus 로고    scopus 로고
    • Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis
    • Li M., Indra A.K., Warot X., Brocard J., Messaddeq N., Kato S., Metzger D., Chambon P. Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 2000, 407:633-636.
    • (2000) Nature , vol.407 , pp. 633-636
    • Li, M.1    Indra, A.K.2    Warot, X.3    Brocard, J.4    Messaddeq, N.5    Kato, S.6    Metzger, D.7    Chambon, P.8
  • 11
    • 33745947286 scopus 로고    scopus 로고
    • Current insights into the formation and breakdown of hemidesmosomes
    • Litjens S.H., de Pereda J.M., Sonnenberg A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol 2006, 16:376-383.
    • (2006) Trends Cell Biol , vol.16 , pp. 376-383
    • Litjens, S.H.1    de Pereda, J.M.2    Sonnenberg, A.3
  • 12
    • 33644523887 scopus 로고    scopus 로고
    • Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication
    • Lopez-Rovira T., Silva-Vargas V., Watt F.M. Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication. J Invest Dermatol 2005, 125:1215-1227.
    • (2005) J Invest Dermatol , vol.125 , pp. 1215-1227
    • Lopez-Rovira, T.1    Silva-Vargas, V.2    Watt, F.M.3
  • 13
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes M.A., Bowcock A.M., Krueger J.G. Pathogenesis and therapy of psoriasis. Nature 2007, 445:866-873.
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 14
    • 36248998854 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS
    • Lu H., Chen J., Planko L., Zigrino P., Klein-Hitpass L., Magin T.M. Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS. J Invest Dermatol 2007, 127:2781-2789.
    • (2007) J Invest Dermatol , vol.127 , pp. 2781-2789
    • Lu, H.1    Chen, J.2    Planko, L.3    Zigrino, P.4    Klein-Hitpass, L.5    Magin, T.M.6
  • 15
    • 0034842640 scopus 로고    scopus 로고
    • Site- and time-specific gene targeting in the mouse
    • Metzger D., Chambon P. Site- and time-specific gene targeting in the mouse. Methods 2001, 24:71-80.
    • (2001) Methods , vol.24 , pp. 71-80
    • Metzger, D.1    Chambon, P.2
  • 17
    • 0026748386 scopus 로고
    • Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin
    • Pellegrini G., De Luca M., Orecchia G., Balzac F., Cremona O., Savoia P., Cancedda R., Marchisio P.C. Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin. J Clin Invest 1992, 89:1783-1795.
    • (1992) J Clin Invest , vol.89 , pp. 1783-1795
    • Pellegrini, G.1    De Luca, M.2    Orecchia, G.3    Balzac, F.4    Cremona, O.5    Savoia, P.6    Cancedda, R.7    Marchisio, P.C.8
  • 18
    • 0029919734 scopus 로고    scopus 로고
    • Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases
    • Piepkorn M. Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol 1996, 18:165-171.
    • (1996) Am J Dermatopathol , vol.18 , pp. 165-171
    • Piepkorn, M.1
  • 19
    • 0032962217 scopus 로고    scopus 로고
    • Mutation analysis and molecular genetics of epidermolysis bullosa
    • Pulkkinen L., Uitto J. Mutation analysis and molecular genetics of epidermolysis bullosa. Matrix Biol 1999, 18:29-42.
    • (1999) Matrix Biol , vol.18 , pp. 29-42
    • Pulkkinen, L.1    Uitto, J.2
  • 20
    • 16844373398 scopus 로고    scopus 로고
    • Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice
    • Raymond K., Kreft M., Janssen H., Calafat J., Sonnenberg A. Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. J Cell Sci 2005, 118:1045-1060.
    • (2005) J Cell Sci , vol.118 , pp. 1045-1060
    • Raymond, K.1    Kreft, M.2    Janssen, H.3    Calafat, J.4    Sonnenberg, A.5
  • 21
    • 34347394552 scopus 로고    scopus 로고
    • Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes
    • Rodius S., Indra G., Thibault C., Pfister V., Georges-Labouesse E. Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes. J Cell Physiol 2007, 212:439-449.
    • (2007) J Cell Physiol , vol.212 , pp. 439-449
    • Rodius, S.1    Indra, G.2    Thibault, C.3    Pfister, V.4    Georges-Labouesse, E.5
  • 22
    • 36048939748 scopus 로고    scopus 로고
    • Biological function of laminin-5 and pathogenic impact of its deficiency
    • Schneider H., Muhle C., Pacho F. Biological function of laminin-5 and pathogenic impact of its deficiency. Eur J Cell Biol 2007, 86:701-717.
    • (2007) Eur J Cell Biol , vol.86 , pp. 701-717
    • Schneider, H.1    Muhle, C.2    Pacho, F.3
  • 24
  • 26
    • 77951605789 scopus 로고    scopus 로고
    • The making of hemidesmosome structures in vivo
    • Zhang H., Labouesse M. The making of hemidesmosome structures in vivo. Dev Dyn 2010, 239:1465-1476.
    • (2010) Dev Dyn , vol.239 , pp. 1465-1476
    • Zhang, H.1    Labouesse, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.