The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties

Molecular and Biochemical Parasitology

Volumn 176, Issue 1, 2011, Pages 25-36

  Freire, Eden R ^a   Dhalia, Rafael ^a   Moura, Danielle M N ^a   Da Costa Lima, Tamara D ^a   Lima, Rodrigo P ^a   Reis, Christian R S ^a   Hughes, Katie ^b   Figueiredo, Regina C B Q ^a   Standart, Nancy ^b   Carrington, Mark ^b   De Melo Neto, Osvaldo P ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

eIF4E; eIF4G; Leishmania; Translation; Trypanosomatid

Indexed keywords

INITIATION FACTOR 4E; INITIATION FACTOR 4G;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GROWTH INHIBITION; KINETOPLASTIDA; METAZOON; MICROBIAL GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA INTERFERENCE; SEQUENCE HOMOLOGY; TRANSLATION INITIATION; TRYPANOSOMA BRUCEI;

EUKARYOTA; HEXAPODA; MAMMALIA; METAZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 78951493869     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.11.011     Document Type: Article

References (52)

1. P.J. Johnson, J.M. Kooter, and P. Borst Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene Cell 51 1987 273 281
2. S. Martinez-Calvillo, S. Yan, and D. Nguyen Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region Mol Cell 11 2003 1291 1299
3. X.H. Liang, A. Haritan, and S. Uliel trans and cis splicing in trypanosomatids: mechanism, factors, and regulation Eukaryot Cell 2 2003 830 840
4. J.D. Bangs, P.F. Crain, and T. Hashizume Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides J Biol Chem 267 1992 9805 9815
5. C.E. Clayton Life without transcriptional control? From fly to man and back again EMBO J 21 2002 1881 1888
6. C. Clayton, and M. Shapira Post-transcriptional regulation of gene expression in trypanosomes and leishmanias Mol Biochem Parasitol 156 2007 93 101
7. S. Haile, and B. Papadopoulou Developmental regulation of gene expression in trypanosomatid parasitic protozoa Curr Opin Microbiol 10 2007 569 577
8. A. Marintchev, and G. Wagner Translation initiation: structures, mechanisms and evolution Q Rev Biophys 37 2004 197 284
9. T. von der Haar, J.D. Gross, and G. Wagner The mRNA cap-binding protein eIF4E in post-transcriptional gene expression Nat Struct Mol Biol 11 2004 503 511
10. B. Culjkovic, I. Topisirovic, and K.L. Borden Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E Cell Cycle 6 2007 65 69
11. N. Sonenberg eIF4E, the mRNA cap-binding protein: from basic discovery to translational research Biochem Cell Biol 86 2008 178 183
12. I.G. Goodfellow, and L.O. Roberts Eukaryotic initiation factor 4E Int J Biochem Cell Biol 40 2008 2675 2680
13. A.C. Gingras, B. Raught, and N. Sonenberg eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation Annu Rev Biochem 68 1999 913 963
14. J.W.B. Hershey, and W.C. Merrick Pathway and mechanism of initiation of protein synthesis N. Sonenberg, J.W.B. Hershey, M.B. Mathews, Translational control of gene expression 2000 Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York 33 88
15. T. Preiss, and M.W. Hentze Starting the protein synthesis machine: eukaryotic translation initiation Bioessays 25 2003 1201 1211
16. R.J. Jackson, C.U. Hellen, and T.V. Pestova The mechanism of eukaryotic translation initiation and principles of its regulation Nat Rev Mol Cell Biol 11 2010 113 127
17. S. Strudwick, and K.L. Borden The emerging roles of translation factor eIF4E in the nucleus Differentiation 70 2002 10 22
18. B. Culjkovic, I. Topisirovic, and L. Skrabanek eIF4E is a central node of an RNA regulon that governs cellular proliferation J Cell Biol 175 2006 415 426
19. I. Topisirovic, N. Siddiqui, and V.L. Lapointe Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP EMBO J 28 2009 1087 1098
20. J. Marcotrigiano, A.C. Gingras, and N. Sonenberg Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP Cell 89 1997 951 961
21. H. Matsuo, H. Li, and A.M. McGuire Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein Nat Struct Biol 4 1997 717 724
22. N. Sonenberg, and A.C. Gingras The mRNA 5′ cap-binding protein eIF4E and control of cell growth Curr Opin Cell Biol 10 1998 268 275
23. B. Raught, and A.C. Gingras eIF4E activity is regulated at multiple levels Int J Biochem Cell Biol 31 1999 43 57
24. G.C. Scheper, and C.G. Proud Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur J Biochem 269 2002 5350 5359
25. P. Lasko, and N. Sonenberg Coordinated transcriptional and translational control in metabolic homeostasis in flies Genes Dev 21 2007 235 237
26. M. Altmann, C. Handschin, and H. Trachsel mRNA cap-binding protein: cloning of the gene encoding protein synthesis initiation factor eIF-4E from Saccharomyces cerevisiae Mol Cell Biol 7 1987 998 1003
27. R.E. Rhoads eIF4E: new family members, new binding partners, new roles J Biol Chem 284 2009 16711 16715
28. P. Lasko, P. Cho, and F. Poulin Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5′-cap structure binding Biochem Soc Trans 33 2005 1544 1546
29. P.F. Cho, C. Gamberi, and Y.A. Cho-Park Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos Curr Biol 16 2006 2035 2041
30. B. Joshi, A. Cameron, and R. Jagus Characterization of mammalian eIF4E-family members Eur J Biochem 271 2004 2189 2203
31. B. Joshi, K. Lee, and D.L. Maeder Phylogenetic analysis of eIF4E-family members BMC Evol Biol 5 2005 48
32. Y. Yoffe, J. Zuberek, and M. Lewdorowicz Cap-binding activity of an eIF4E homolog from Leishmania RNA 10 2004 1764 1775
33. R. Dhalia, C.R. Reis, and E.R. Freire Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues Mol Biochem Parasitol 140 2005 23 41
34. Y. Yoffe, J. Zuberek, and A. Lerer Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania Eukaryot Cell 5 2006 1969 1979
35. R. Dhalia, N. Marinsek, and C.R. Reis The two eIF4A helicases in Trypanosoma brucei are functionally distinct Nucleic Acids Res 34 2006 2495 2507
36. S. Kelly, J. Reed, and S. Kramer Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci Mol Biochem Parasitol 154 2007 103 109
37. B. Wickstead, K. Ersfeld, and K. Gull Targeting of a tetracycline- inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei Mol Biochem Parasitol 125 2002 211 216
38. E. Wirtz, S. Leal, and C. Ochatt A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei Mol Biochem Parasitol 99 1999 89 101
39. M. Carrington, I. Roditi, and R.O. Williams The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei Nucleic Acids Res 15 1987 10179 10198
40. H. Webb, R. Burns, and L. Ellis Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor Nucleic Acids Res 33 2005 1503 1512
41. J. Marcotrigiano, A.C. Gingras, and N. Sonenberg Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G Mol Cell 3 1999 707 716
42. S. Kramer, R. Queiroz, and L. Ellis Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169 J Cell Sci 121 2008 3002 3014
43. Y. Yoffe, M. Leger, and A. Zinoviev Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactions Nucleic Acids Res 37 2009 3243 3253
44. G. Hernandez, and P. Vazquez-Pianzola Functional diversity of the eukaryotic translation initiation factors belonging to eIF4 families Mech Dev 122 2005 865 876
45. J. Dostie, F. Lejbkowicz, and N. Sonenberg Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles J Cell Biol 148 2000 239 247
46. K.S. Browning, C. Webster, and J.K. Roberts Identification of an isozyme form of protein synthesis initiation factor 4F in plants J Biol Chem 267 1992 10096 10100
47. D.R. Gallie, and K.S. Browning eIF4G functionally differs from eIFiso4G in promoting internal initiation, cap-independent translation, and translation of structured mRNAs J Biol Chem 276 2001 36951 36960
48. L.K. Mayberry, M.L. Allen, and M.D. Dennis Evidence for variation in the optimal translation initiation complex: plant eIF4B, eIF4F, and eIF(iso)4F differentially promote translation of mRNAs Plant Physiol 150 2009 1844 1854
49. I.R. Nett, D.M. Martin, and D. Miranda-Saavedra The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness Mol Cell Proteomics 8 2009 1527 1538
50. M. Rau, T. Ohlmann, and S.J. Morley A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate J Biol Chem 271 1996 8983 8990
51. P.F. Cho, F. Poulin, and Y.A. Cho-Park A new paradigm for translational control: inhibition via 5′-3′ mRNA tethering by Bicoid and the eIF4E cognate 4EHP Cell 121 2005 411 423
52. J. Zuberek, D. Kubacka, and A. Jablonowska Weak binding affinity of human 4EHP for mRNA cap analogs RNA 13 2007 691 697