Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus

BMC Geriatrics

Volumn 11, Issue , 2011, Pages

  Herzig, Karl Heinz ^a,b   Purhonen, Anna Kaisa ^a,b   Räsänen, Kati M ^a   Idziak, Joanna ^a   Juvonen, Petri ^c   Phillps, Ryszard ^d   Walkowiak, Jaroslaw ^e  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d District Hospital   (Poland)

^e POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

PANCREATIC ELASTASE;

AGED; AGING; ARTICLE; CHEMISTRY; CROSS-SECTIONAL STUDY; ENZYMOLOGY; FECES; FEMALE; HUMAN; MALE; MIDDLE AGED; PANCREAS EXOCRINE INSUFFICIENCY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; AGING; CROSS-SECTIONAL STUDIES; EXOCRINE PANCREATIC INSUFFICIENCY; FECES; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATIC ELASTASE;

EID: 78951484478     PISSN: None     EISSN: 14712318     Source Type: Journal    
DOI: 10.1186/1471-2318-11-4     Document Type: Article

References (31)

1. Detlefsen S, Sipos B, Feyerabend B, Kloppel G: Pancreatic fibrosis associated with age and ductal papillary hyperplasia. Virchows Arch 2005, 447:800-805. (Pubitemid 41728867)
2. Pitchumoni CS, Glasser M, Saran RM, Panchacharam P, Thelmo W: Pancreatic fibrosis in chronic alcoholics and nonalcoholics without clinical pancreatitis. Am J Gastroenterol 1984, 79:382-388. (Pubitemid 14147860)
3. Schmitz-Moormann P, Hein J: Changes of the pancreatic duct system associated with aging: their relations to parenchyma (author's transl). Virchows Arch A Pathol Anat Histol 1976, 371:145-152.
4. Stamm BH: Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol 1984, 15:677-683.
5. Gullo L, Ventrucci M, Naldoni P, Pezzilli R: Aging and exocrine pancreatic function. J Am Geriatr Soc 1986, 34:790-792. (Pubitemid 17178746)
6. Gullo L, Simoni P, Migliori M, Lucrezio L, Bassi M, Frau F, Costa PL, Nestico V: A study of pancreatic function among subjects over ninety years of age. Pancreatology 2009, 9:240-244.
7. Laugier R, Bernard JP, Berthezene P, Dupuy P: Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion 1991, 50:202-211.
8. Vellas B, Balas D, Moreau J, Bouisson M, Senegas-Balas F, Guidet M, Ribet A: Exocrine pancreatic secretion in the elderly. Int J Pancreatol 1988, 3:497-502. (Pubitemid 19046345)
9. Mossner J, Pusch HJ, Koch W: Exocrine pancreas function - does it change with age? (author's transl). Aktuelle Gerontol 1982, 12:40-43.
10. Rothenbacher D, Low M, Hardt PD, Klor HU, Ziegler H, Brenner H: Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population based study. Scand J Gastroenterol 2005, 40:697-704. (Pubitemid 40827532)
11. Walkowiak J, Cichy WK, Herzig KH: Comparison of fecal elastase-1 determination with the secretin-cholecystokinin test in patients with cystic fibrosis. Scand J Gastroenterol 1999, 34:202-207. (Pubitemid 29138874)
12. Walkowiak J, Nousia-Arvanitakis S, Agguridaki C, Fotoulaki M, Strzykala K, Balassopoulou A, Witt M, Herzig KH: Longitudinal follow-up of exocrine pancreatic function in pancreatic sufficient cystic fibrosis patients using the fecal elastase-1 test. J Pediatr Gastroenterol Nutr 2003, 36:474-478. (Pubitemid 39280886)
13. Luth S, Teyssen S, Forssmann K, Kolbel C, Krummenauer F, Singer MV: Fecal elastase-1 determination: 'gold standard' of indirect pancreatic function tests? Scand J Gastroenterol 2001, 36:1092-1099.
14. Talley NJ, O'Keefe EA, Zinsmeister AR, Melton LJ: Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology 1992, 102:895-901.
15. Hardt PD, Krauss A, Bretz L, Porsch-Ozcurumez M, Schnell-Kretschmer H, Maser E, Bretzel RG, Zekhorn T, Klor HU: Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus. Acta Diabetol 2000, 37:105-110. (Pubitemid 32157309)
16. Gullo L, Ventrucci M, Tomassetti P, Migliori M, Pezzilli R: Fecal elastase 1 determination in chronic pancreatitis. Dig Dis Sci 1999, 44:210-213. (Pubitemid 29053101)
17. Loser C, Mollgaard A, Folsch UR: Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test. Gut 1996, 39:580-586. (Pubitemid 26376043)
18. Lankisch PG, Schmidt I, Konig H, Lehnick D, Knollmann R, Lohr M, Liebe S: Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. Gut 1998, 42:551-554. (Pubitemid 28186574)
19. Naruse S, Ishiguro H, Ko SB, Yoshikawa T, Yamamoto T, Yamamoto A, Futakuchi S, Goto H, Saito Y, Takahashi S: Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency. J Gastroenterol 2006, 41:901-908. (Pubitemid 44594232)
20. Glasbrenner B, Schon A, Klatt S, Beckh K, Adler G: Clinical evaluation of the faecal elastase test in the diagnosis and staging of chronic pancreatitis. Eur J Gastroenterol Hepatol 1996, 8:1117-1120. (Pubitemid 26383872)
21. DECODE Study Group: Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 2003, 26:61-69.
22. Rathmann W, Haastert B, Icks A, Giani G, Hennings S, Mitchell J, Curran S, Wareham NJ: Low faecal elastase 1 concentrations in type 2 diabetes mellitus. Scand J Gastroenterol 2001, 36:1056-1061. (Pubitemid 32801690)
23. Icks A, Haastert B, Giani G, Rathmann W: Low fecal elastase-1 in type I diabetes mellitus. Z Gastroenterol 2001, 39:823-830. (Pubitemid 33020961)
24. Hardt PD, Hauenschild A, Nalop J, Marzeion AM, Jaeger C, Teichmann J, Bretzel RG, Hollenhorst M, Kloer HU, S2453112/S2453113 Study Group: High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients. Pancreatology 2003, 3:395-402.
25. Bilgin M, Balci NC, Momtahen AJ, Bilgin Y, Klor HU, Rau WS: MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. J Clin Gastroenterol 2009, 43:165-170.
26. Walkowiak J, Herzig KH: Fecal elastase-1 is decreased in villous atrophy regardless of the underlying disease. Eur J Clin Invest 2001, 31:425-430. (Pubitemid 32476962)
27. Walkowiak J, Krawczynski M, Herzig KH: Giardiasis aggravates malabsorption in cystic fibrosis. Scand J Gastroenterol 2004, 39:607-608. (Pubitemid 38916270)
28. Whitcomb DC, Lehman GA, Vasileva G, Malecka-Panas E, Gubergrits N, Shen Y, Sander-Struckmeier S, Caras S: Pancrelipase Delayed-Release Capsules (CREON) for Exocrine Pancreatic Insufficiency due to Chronic Pancreatitis or Pancreatic Surgery: A Double-Blind Randomized Trial. Am J Gastroenterol 2010, 105:2276-2286.
29. Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S, Sanders DS: Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin Gastroenterol Hepatol 2010, 8:433-438.
30. Dumasy V, Delhaye M, Cotton F, Deviere J: Fat malabsorption screening in chronic pancreatitis. Am J Gastroenterol 2004, 99:1350-1354. (Pubitemid 39062275)
31. Sikkens EC, Cahen DL, Kuipers EJ, Bruno MJ: Pancreatic enzyme replacement therapy in chronic pancreatitis. Best Pract Res Clin Gastroenterol 2010, 24:337-347.