Inhibin/activin-betaE subunit is expressed in normal and pathological human placental tissue including chorionic carcinoma cell lines

Archives of Gynecology and Obstetrics

Volumn 283, Issue 2, 2011, Pages 223-230

  Gingelmaier, Andrea ^a   Brüning, Ansgar ^a   Kimmich, Tanja ^a   Makovitzky, Josef ^b   Bergauer, Florian ^a   Schiessl, Barbara ^a   Friese, Klaus ^a   Mylonas, Ioannis ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Choriocarcinoma cell lines; HELLP syndrome; Immunofluorescence; Immunohistochemistry; Inhibin betaE; Placenta; Preeclampsia; RT PCR

Indexed keywords

ACTIVIN; ACTIVIN BETAE SUBUNIT; INHIBIN; INHIBIN BETAE SUBUNIT; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; AUTOCRINE EFFECT; CARCINOMA CELL; CHORIOCARCINOMA; CONTROLLED STUDY; DECIDUALIZATION; FEMALE; GENE EXPRESSION REGULATION; HELLP SYNDROME; HISTOPATHOLOGY; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PARACRINE SIGNALING; PLACENTA CIRCULATION; PREECLAMPSIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REGENERATION; TROPHOBLAST;

CELL LINE, TUMOR; CHORIOCARCINOMA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HELLP SYNDROME; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBIN-BETA SUBUNITS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UTERINE NEOPLASMS;

EID: 78751706698     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-009-1340-5     Document Type: Article

References (40)

1. Y Xia AL Schneyer 2009 The biology of activin: recent advances in structure, regulation and function J Endocrinol 202 1 12 1:CAS:528: DC%2BD1MXosl2mt70%3D 10.1677/JOE-08-0549 19273500
2. W Vale E Wiater P Gray C Harrison L Bilezikjian S Choe 2004 Activins and inhibins and their signaling Ann N Y Acad Sci 1038 142 147 1:CAS:528: DC%2BD2MXksVynsro%3D 10.1196/annals.1315.023 15838109
3. I Mylonas U Jeschke I Wiest A Hoeing J Vogl N Shabani C Kuhn S Schulze MS Kupka K Friese 2004 Inhibin/activin subunits alpha, beta-A and beta-B are differentially expressed in normal human endometrium throughout the menstrual cycle Histochem Cell Biol 122 461 471 1:CAS:528:DC%2BD2cXhtVSitLvO 10.1007/s00418-004-0709-6 15480736
4. S Worbs N Shabani D Mayr A Gingelmaier A Makrigiannakis C Kuhn U Jeschke MS Kupka K Friese I Mylonas 2007 Expression of the inhibin/activin subunits (-alpha, -betaA and -betaB) in normal and carcinogenic endometrial tissue: possible immunohistochemical differentiation markers Oncol Rep 17 97 104 1:CAS:528:DC%2BD2sXhtFagt7k%3D 17143484
5. F Petraglia GC Garuti L Calza V Roberts L Giardino AR Genazzani W Vale H Meunier 1991 Inhibin subunits in human placenta: localization and messenger ribonucleic acid levels during pregnancy Am J Obstet Gynecol 165 750 758 1:CAS:528:DyaK3MXmt1eqs7w%3D 1892206
6. I Mylonas B Schiessl U Jeschke J Vogl A Makrigiannakis C Kuhn S Kunze S Schulze F Kainer K Friese 2006 Expression of inhibin/activin subunits alpha (-alpha), betaA (-beta (A)) and betaB (-beta (B)) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies J Mol Histol 37 43 52 1:CAS:528:DC%2BD28XptVertLY%3D 10.1007/s10735-006-9029-6 16670820
7. I Mylonas B Schiessl U Jeschke J Vogl A Makrigiannakis C Kuhn S Schulze F Kainer K Friese 2006 Expression of inhibin/activin subunits alpha (-alpha), betaA (-betaA), and betaB (-betaB) in placental tissue of normal, preeclamptic, and HELLP pregnancies Endocr Pathol 17 19 33 1:CAS:528:DC%2BD28XntVSrtb0%3D 10.1385/EP:17:1:19 16760577
8. I Mylonas N Shabani J Vogl J Makovitzky S Kunze C Kuhn S Schulze K Friese U Jeschke 2007 Inhibin/activin subunits are immunohistochemically expressed in complete and partial hydatidiform moles Anticancer Res 27 1995 2000 1:CAS:528:DC%2BD2sXotVCqsbw%3D 17649811
9. C Welt Y Sidis H Keutmann A Schneyer 2002 Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium Exp Biol Med (Maywood) 227 724 752 1:CAS:528:DC%2BD38XntlyqsLg%3D
10. DM de Kretser MP Hedger KL Loveland DJ Phillips 2002 Inhibins, activins and follistatin in reproduction Hum Reprod Update 8 529 541 10.1093/humupd/8.6. 529 12498423
11. I Mylonas S Worbs N Shabani C Kuhn S Kunze S Schulze D Dian A Gingelmaier C Schindlbeck A Bruning H Sommer U Jeschke K Friese 2009 Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases Eur J Cancer 45 1304 1314 1:CAS:528:DC%2BD1MXktlyqtLo%3D 10.1016/j.ejca.2009.01.008 19231155
12. W Vale C Rivier A Hsueh C Campen H Meunier T Bicsak J Vaughan A Corrigan W Bardin P Sawchenko, et al. 1988 Chemical and biological characterization of the inhibin family of protein hormones Recent Prog Horm Res 44 1 34 1:CAS:528:DyaL1MXhvVKjsLc%3D 3064204
13. G Hötten H Neidhardt C Schneider J Pohl 1995 Cloning of a new member of the TGF-beta family: a putative new activin beta C chain Biochem Biophys Res Commun 206 608 613 10.1006/bbrc.1995.1086
14. S Oda S Nishimatsu K Murakami N Ueno 1995 Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus Biochem Biophys Res Commun 210 581 588 1:CAS:528: DyaK2MXls1ansbg%3D 10.1006/bbrc.1995.1699 7755637
15. J Fang W Yin E Smiley SQ Wang J Bonadio 1996 Molecular cloning of the mouse activin betaE subunit gene Biochem Biophys Res Commun 228 669 674 1:CAS:528:DyaK28XntVWrur4%3D 10.1006/bbrc.1996.1715 8941337
16. O Hashimoto K Tsuchida Y Ushiro Y Hosoi N Hoshi H Sugino Y Hasegawa 2002 cDNA cloning and expression of human activin betaE subunit Mol Cell Endocrinol 194 117 122 1:CAS:528:DC%2BD38XntVaqurY%3D 10.1016/S0303-7207(02)00157-0 12242034
17. WG McCluggage P Ashe H McBride P Maxwell JM Sloan 1998 Localization of the cellular expression of inhibin in trophoblastic tissue Histopathology 32 252 256 1:STN:280:DyaK1c3ivF2gsQ%3D%3D 10.1046/j.1365-2559.1998.00385.x 9568511
18. S Muttukrishna PG Knight NP Groome CW Redman WL Ledger 1997 Activin A and inhibin A as possible endocrine markers for pre-eclampsia Lancet 349 1285 1288 1:CAS:528:DyaK2sXjsVejt78%3D 10.1016/S0140-6736(96)09264-1 9142063
19. DA Aitken EM Wallace JA Crossley IA Swanston Y van Pareren M van Maarle NP Groome JN Macri JM Connor 1996 Dimeric inhibin A as a marker for Down's syndrome in early pregnancy N Engl J Med 334 1231 1236 1:STN:280: DyaK287ps1OksA%3D%3D 10.1056/NEJM199605093341904 8606718
20. B Schiessl I Mylonas P Hantschmann C Kuhn S Schulze S Kunze K Friese U Jeschke 2005 Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies J Histochem Cytochem 53 1441 1449 1:CAS:528:DC%2BD2MXht1OnsLrI 10.1369/jhc.4A6480.2005 15983116
21. I Mylonas J Makovitzky N Shabani A Gingelmaier D Dian C Kuhn S Schulze S Kunze U Jeschke K Friese 2009 Development and characterisation of an antibody for the immunohistochemical detection of inhibin/activin betaE (betaE) in normal human ovarian and placental tissue Acta Histochem 111 366 371 19195688
22. Kimmich T, Brüning A, Käufl SD, Makovitzky J, Kuhn C, Jeschke U, Friese K, Mylonas I (2009) Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line. Arch Gynecol Obstet. doi: 10.1007/s00404-009-1310-y
23. A Bruning J Makovitzky A Gingelmaier K Friese I Mylonas 2009 The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells Histochem Cell Biol 132 33 38 10.1007/s00418-009-0595-z 19363681
24. Bergauer F, Brüning A, Shabani N, Blankenstein T, Jückstock J, Dian D, Mylonas I (2009) Inhibin/activin-betaE subunit in normal and malignant human cervical tissue and cervical cancer cell lines. J Mol Histol. doi: 10.1007/s10735-009-9246-x
25. AL Lau TR Kumar K Nishimori J Bonadio MM Matzuk 2000 Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration Mol Cell Biol 20 6127 6137 1:CAS:528:DC%2BD3cXlsl2gtrk%3D 10.1128/MCB.20.16.6127-6137.2000 10913194
26. P Florio L Cobellis S Luisi P Ciarmela FM Severi C Bocchi F Petraglia 2001 Changes in inhibins and activin secretion in healthy and pathological pregnancies Mol Cell Endocrinol 180 123 130 1:CAS:528:DC%2BD3MXltVaqs78%3D 10.1016/S0303-7207(01)00503-2 11451581
27. RL Jones LA Salamonsen JK Findlay 2002 Potential roles for endometrial inhibins, activins and follistatin during human embryo implantation and early pregnancy Trends Endocrinol Metab 13 144 150 1:CAS:528:DC%2BD38Xjs1Kmt7k%3D 10.1016/S1043-2760(01)00559-8 11943557
28. I Caniggia SJ Lye JC Cross 1997 Activin is a local regulator of human cytotrophoblast cell differentiation Endocrinology 138 3976 3986 1:CAS:528:DyaK2sXlsFeisb4%3D 10.1210/en.138.9.3976 9275089
29. DJ Phillips DM de Kretser MP Hedger 2009 Activin and related proteins in inflammation: not just interested bystanders Cytokine Growth Factor Rev 20 153 164 1:CAS:528:DC%2BD1MXktl2jtLw%3D 10.1016/j.cytogfr.2009.02.007 19261538
30. JA Keelan RL Zhou MD Mitchell 2000 Activin A exerts both pro- and anti-inflammatory effects on human term gestational tissues Placenta 21 38 43 1:CAS:528:DC%2BD3cXhvFCjtLc%3D 10.1053/plac.1999.0451 10692249
31. S Vejda N Erlach B Peter C Drucker W Rossmanith J Pohl R Schulte-Hermann M Grusch 2003 Expression of activins C and E induces apoptosis in human and rat hepatoma cells Carcinogenesis 24 1801 1809 1:CAS:528:DC%2BD3sXovVeksL4%3D 10.1093/carcin/bgg154 12949049
32. S Vejda M Cranfield B Peter SL Mellor N Groome R Schulte-Hermann W Rossmanith 2002 Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers J Mol Endocrinol 28 137 148 1:CAS:528:DC%2BD38Xjt1GrsLk%3D 10.1677/jme.0.0280137 11932210
33. K Takamura K Tsuchida H Miyake S Tashiro H Sugino 2005 Activin and activin receptor expression changes in liver regeneration in rat J Surg Res 126 3 11 1:CAS:528:DC%2BD2MXks1eisrY%3D 10.1016/j.jss.2005.01.002 15916968
34. W Wada JJ Medina H Kuwano I Kojima 2005 Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes Endocr J 52 169 175 1:CAS:528:DC%2BD2MXmtFyms7k%3D 10.1507/endocrj.52.169 15863943
35. M Chabicovsky K Herkner W Rossmanith 2003 Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells Endocrinology 144 3497 3504 1:CAS:528:DC%2BD3sXlslGjtrk%3D 10.1210/en.2003-0388 12865331
36. C Rodgarkia-Dara S Vejda N Erlach A Losert W Bursch W Berger R Schulte-Hermann M Grusch 2006 The activin axis in liver biology and disease Mutat Res 613 123 137 1:CAS:528:DC%2BD28Xht1ersLzI 10.1016/j.mrrev.2006.07.002 16997617
37. DJ Phillips KL Jones JY Scheerlinck MP Hedger DM de Kretser 2001 Evidence for activin A and follistatin involvement in the systemic inflammatory response Mol Cell Endocrinol 180 155 162 1:CAS:528:DC%2BD3MXltVaqsL0%3D 10.1016/S0303-7207(01)00516-0 11451586
38. SA McCarthy R Bicknell 1993 Inhibition of vascular endothelial cell growth by activin-A J Biol Chem 268 23066 23071 1:CAS:528:DyaK3sXlslCgtLo%3D 8226823
39. NA Bersinger N Groome S Muttukrishna 2002 Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term Eur J Endocrinol 147 785 793 1:CAS:528: DC%2BD3sXht1KmsQ%3D%3D 10.1530/eje.0.1470785 12457454
40. S Muttukrishna RA North J Morris JC Schellenberg RS Taylor J Asselin W Ledger N Groome CW Redman 2000 Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia Hum Reprod 15 1640 1645 1:CAS:528: DC%2BD38XptlGmsb4%3D 10.1093/humrep/15.7.1640 10875882