Water deprivation increases Fos immunoreactivity in PVN autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 5 56-5, 2004, Pages

  Stocker, Sean D ^a,b   Cunningham, J Thomas ^b   Toney, Glenn M ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Dehydration; Hyperosmolality; Hypovolemia; Parvocellular; Sympathetic outflow

Indexed keywords

BIOCHEMICAL MARKER; CHOLERA TOXIN B SUBUNIT; FLUOROGOLD; PROTEIN FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVE; BRAIN CELL; BRAIN STEM; CONTROLLED STUDY; FOOD DEPRIVATION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOREACTIVITY; MALE; MICROINJECTION; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ROSTRAL VENTROLATERAL MEDULLA; SPINAL CORD; SYMPATHETIC NERVE CELL; SYNAPSE; WATER DEPRIVATION;

ANIMALS; BLOOD PRESSURE; BLOOD PROTEINS; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; MALE; MEDULLA OBLONGATA; NEURAL PATHWAYS; NEURONS; ONCOGENE PROTEINS V-FOS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; WATER DEPRIVATION;

EID: 6344267062     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00394.2004     Document Type: Article

References (57)

1. Badoer E. Hypothalamic paraventricular nucleus and cardiovascular regulation. Clin Exp Pharmacol Physiol 28: 95-99, 2001.
2. Badoer E and McKinlay D. Effect of intravenous angiotensin II on Fos distribution and drinking behavior in rabbits. Am J Physiol Regul Integr Comp Physiol 272: R1515-R1524, 1997.
3. Badoer E, McKinley MJ, Oldfield BJ, and McAllen RM. Distribution of hypothalamic, medullary and lamina terminalis neurons expressing Fos after hemorrhage in conscious rats. Brain Res 582: 323-328, 1992.
4. Badoer E, McKinley MJ, Oldfield BJ, and McAllen RM. A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla. Brain Res 610: 216-223, 1993.
5. Badoer E and Merolli J. Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are activated by haemorrhage. Brain Res 791: 317-320, 1998.
6. Bains JS and Ferguson AV. Paraventricular nucleus neurons projecting to the spinal cord receive excitatory input from the subfornical organ. Am J Physiol Regul Integr Comp Physiol 268: R625-R633, 1995.
7. Brooks VL, Freeman KL, and Clow KA. Excitatory amino acids in rostral ventrolateral medulla support blood pressure during water deprivation in rats. Am J Physiol Heart Circ Physiol 286: H1642-H1648, 2004.
8. Brown DL and Guyenet PG. Cardiovascular neurons of brain stem with projections to spinal cord. Am J Physiol Regul Integr Comp Physiol 247: R1009-R1016, 1984.
9. Chen QH and Toney GM. AT(1)-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation. Am J Physiol Regul Integr Comp Physiol 281: R1844-R1853, 2001.
10. Chen QH and Toney GM. Discharge properties and osmotic responsiveness of hypothalamic PVN neurons projecting to the ventrolateral medulla and spinal cord (Abstract). FASEB J 14: 458.6, 2000.
11. Cunningham JT, Penny ML, and Murphy D. Cardiovascular regulation of supraoptic neurons in the rat: synaptic inputs and cellular signals. Prog Biophys Mol Biol 84: 183-196, 2004.
12. Dampney RA. The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog Neurobiol 42: 197-227, 1994.
13. Dampney RA and Horiuchi J. Functional organisation of central cardiovascular pathways: studies using c-fos gene expression. Prog Neurobiol 71: 359-384, 2003.
14. Dragunow M and Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods 29: 261-265, 1989.
15. Ferguson AV. Paraventricular nucleus neurons projecting to the dorsomedial medulla are influenced by systemic angiotensin. Brain Res Bull 20: 197-201, 1988.
16. Ferguson AV and Washburn DL. Angiotensin II: a peptidergic neurotransmitter in central autonomic pathways. Prog Neurobiol 54: 169-192, 1998.
17. Gardiner SM and Bennett T. Interactions between neural mechanisms, the renin-angiotensin system and vasopressin in the maintenance of blood pressure during water deprivation: studies in Long Evans and Brattleboro rats. Clin Sci (Lond) 68: 647-657, 1985.
18. Gutman MB, Jones DL, and Ciriello J. Effect of paraventricular nucleus lesions on drinking and pressor responses to ANG II. Am J Physiol Regul Integr Comp Physiol 255: R882-R887, 1988.
19. Guyenet PG, Koshiya N, Huangfu D, Baraban SC, Stornetta RL, and Li YW. Role of medulla oblongata in generation of sympathetic and vagal outflows. Prog Brain Res 107, 1996.
20. Haselton JR, Goering J, and Patel KP. Parvocellular neurons of the paraventricular nucleus are involved in the reduction in renal nerve discharge during isotonic volume expansion. J Auton Nerv Syst 50: 1-11, 1994.
21. Herdegen T and Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28: 370-490, 1998.
22. Kantzides A and Badoer E. Fos, RVLM-projecting neurons, and spinally projecting neurons in the PVN following hypertonic saline infusion. Am J Physiol Regul Integr Comp Physiol 284: R945-R953, 2003.
23. Kiely JM and Gordon FJ. Role of rostral ventrolateral medulla in centrally mediated pressor responses. Am J Physiol Heart Circ Physiol 267: H1549-H1556, 1994.
24. Lovick TA and Coote JH. Effects of volume loading on paraventriculospinal neurones in the rat. J Auton Nerv Syst 25: 135-140, 1988.
25. Lovick TA, Malpas S, and Mahony MT. Renal vasodilatation in response to acute volume load is attenuated following lesions of parvocellular neurones in the paraventricular nucleus in rats. J Auton Nerv Syst 43: 247-255, 1993.
26. Luckman SM, Dyball RE, and Leng G. Induction of c-fos expression in hypothalamic magnocellular neurons requires synaptic activation and not simply increased spike activity. J Neurosci 14: 4825-4830, 1994.
27. McKinley MJ, Hards DK, and Oldfield BJ. Identification of neural pathways activated in dehydrated rats by means of Fos-immunohistochemistry and neural tracing. Brain Res 653: 305-314, 1994.
28. Miyata S, Nakashima T, and Kiyohara T. Expression of c-fos immunoreactivity in the hypothalamic magnocellular neurons during chronic osmotic stimulations. Neurosci Lett 175: 63-66, 1994.
29. Morgan JI and Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 14: 421-451, 1991.
30. Morien A, Garrard L, and Rowland NE. Expression of Fos immunoreactivity in rat brain during dehydration: effect of duration and timing of water deprivation. Brain Res 816: 1-7, 1999.
31. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (CD-ROM). San Diego, CA: Academic, 1998.
32. Potts PD, Ludbrook J, Gillman-Gaspari TA, Horiuchi J, and Dampney RA. Activation of brain neurons following central hypervolaemia and hypovolaemia: contribution of baroreceptor and non-baroreceptor inputs. Neuroscience 95: 499-511, 2000.
33. Pyner S and Coote JH. Identification of an efferent projection from the paraventricular nucleus of the hypothalamus terminating close to spinally projecting rostral ventrolateral medullary neurons. Neuroscience 88: 949-957, 1999.
34. Pyner S and Coote JH. Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience 100: 549-556, 2000.
35. Pyner S, Deering J, and Coote JH. Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats. Exp Physiol 87: 25-32, 2002.
36. Rinaman L, Stricker EM, Hoffman GE, and Verbalis JG. Central c-Fos expression in neonatal and adult rats after subcutaneous injection of hypertonic saline. Neuroscience 79: 1165-1175, 1997.
37. Saper CB, Loewy AD, Swanson LW, and Cowan WM. Direct hypothalamo- autonomic connections. Brain Res 117: 305-312, 1976.
38. Schreihofer AM and Guyenet PG. Identification of C1 presympathetic neurons in rat rostral ventrolateral medulla by juxtacellular labeling in vivo. J Comp Neurol 387: 524-536, 1997.
39. Schreihofer AM, Hoffman GE, and Sved AF. The kidneys stimulate vasopressin release during hemorrhage in rats with chronic NTS lesions. Am J Physiol Regul Integr Comp Physiol 272: R1540-R1551, 1997.
40. Scrogin KE, Grygielko ET, and Brooks VL. Osmolality: a physiological long-term regulator of lumbar sympathetic nerve activity and arterial pressure. Am J Physiol Regul Integr Comp Physiol 276: R1579-R1586, 1999.
41. Scrogin KE, McKeogh DF, and Brooks VL. Is osmolality a long-term regulator of renal sympathetic nerve activity in conscious water-deprived rats? Am J Physiol Regul Integr Comp Physiol 282: R560-R568, 2002.
42. Shafton AD, Ryan A, and Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res 801: 239-243, 1998.
43. Somponpun SJ, Johnson AK, Beltz T, and Sladek CD. Osmotic regulation of estrogen receptor-β expression in magnocellular vasopressin neurons requires lamina terminalis. Am J Physiol Regul Integr Comp Physiol 286: R465-R473, 2004.
44. Stocker SD, Keith KJ, and Toney GM. Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats. Am J Physiol Regul Integr Comp Physiol 286: R719-R725, 2004.
45. Stocker SD, Stricker EM, and Sved AF. Acute hypertension inhibits thirst stimulated by ANG II, hyperosmolality, or hypovolemia in rats. Am J Physiol Regul Integr Comp Physiol 280: R214-R224, 2001.
46. Sved JC, Sved AF, and Card JP. Hypothalamic projections to rostral ventrolateral medulla and thoracic spinal cord: 2004 Experimental Biology meeting abstracts [http://select.biosis.org/faseb/eb2004_data/FASEB006735. html] FASEB J 18: 444.4, 2004.
47. Swanson LW and Kuypers HG. The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 194: 555-570, 1980.
48. Swanson LW and Sawchenko PE. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31: 410-417, 1980.
49. Tagawa T and Dampney RA. AT(1) receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus. Hypertension 34: 1301-1307, 1999.
50. Thornton RM and Proppe DW. Influence of vasoconstrictor systems on leg vasodilation during heating of dehydrated baboons. Am J Physiol Heart Circ Physiol 254: H11-H19, 1988.
51. Toney GM, Chen QH, Cato MJ, and Stocker SD. Central osmotic regulation of sympathetic nerve activity. Acta Physiol Scand 177: 43-55, 2003.
52. Verberne AJ, Stornetta RL, and Guyenet PG. Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat. J Physiol 517: 477-494, 1999.
53. Watson RE Jr, Wiegand SJ, Clough RW, and Hoffman GE. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides 7: 155-159, 1986.
54. Xu Z and Herbert J. Effects of unilateral or bilateral lesions within the anteroventral third ventricular region on c-fos expression induced by dehydration or angiotensin II in the supraoptic and paraventricular nuclei of the hypothalamus. Brain Res 713: 36-43, 1996.
55. Yang Z, Bertram D, and Coote JH. The role of glutamate and vasopressin in the excitation of RVL neurones by paraventricular neurones. Brain Res 908: 99-103, 2001.
56. Yang Z and Coote JH. Role of GABA and NO in the paraventricular nucleus-mediated reflex inhibition of renal sympathetic nerve activity following stimulation of right atrial receptors in the rat. Exp Physiol 88: 335-342, 2003.
57. Yang Z and Coote JH. Influence of the hypothalamic paraventricular nucleus on cardiovascular neurones in the rostral ventrolateral medulla of the rat. J Physiol 513: 521-530, 1998.