Emerging nanotechnology approaches in tissue engineering for peripheral nerve regeneration

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 1, 2011, Pages 50-59

  Cunha, Carla ^a   Panseri, Silvia ^b,c   Antonini, Stefania ^d  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Drug delivery; Nanobiomaterials; Nanofibers; Nervous regeneration; Neural stem cells

Indexed keywords

CELL-BINDING DOMAIN; FUNCTIONAL RECOVERY; FUNCTIONALIZED; INNOVATIVE APPROACHES; MICROENVIRONMENTS; NANOBIOMATERIALS; NERVE GRAFTS; NERVE REGENERATION; NERVOUS REGENERATION; NEURAL STEM CELL; NEUROTROPHIC FACTORS; NEUROTROPIC FACTORS; PERIPHERAL NERVE REGENERATION; PERIPHERAL NERVE REPAIR; PERIPHERAL NERVES; REGENERATIVE MEDICINE; SUSTAINED RELEASE;

BIOMIMETICS; DRUG DELIVERY; INNOVATION; NANOFIBERS; SCAFFOLDS; STEM CELLS; TISSUE; TISSUE ENGINEERING;

NANOTECHNOLOGY;

BASIC FIBROBLAST GROWTH FACTOR; BIOMATERIAL; CEFOXITIN; CHITOSAN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LAMININ; MOLECULAR SCAFFOLD; NANOFIBER; NANOMATERIAL; NERVE GROWTH FACTOR BETA SUBUNIT; NEUROTROPHIC FACTOR; POLYCAPROLACTONE; POLYESTER; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYLACTIDE; SELF ASSEMBLED MONOLAYER;

BINDING KINETICS; BIODEGRADABILITY; CELL THERAPY; CONTROLLED DRUG RELEASE; DEGENERATIVE DISEASE; DRUG DELIVERY SYSTEM; ELECTROSPINNING; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; NANOFABRICATION; NANOTECHNOLOGY; NERVE GROWTH; NERVE REGENERATION; NEURAL STEM CELL; NONHUMAN; PERIPHERAL NERVE INJURY; PHASE SEPARATION; PROSTHESIS; REVIEW; SCHWANN CELL; TISSUE ENGINEERING;

ANIMALS; GUIDED TISSUE REGENERATION; HUMANS; NANOTECHNOLOGY; NERVE REGENERATION; NEURAL STEM CELLS; PERIPHERAL NERVES; PERIPHERAL NERVOUS SYSTEM DISEASES; TISSUE ENGINEERING;

EID: 78751705551     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2010.07.004     Document Type: Review

References (87)

1. Liu W., Cao Y. Application of scaffold materials in tissue reconstruction in immunocompetent mammals: our experience and future requirements. Biomaterials 2007, 28:5078-5086.
2. Sachlos E., Czernuszka J.T. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater 2003, 5:29-40.
3. Matthews J.A., Wnek G.E., Simpson D.G., Bowlin G.L. Electrospinning of collagen nanofibers. Biomacromolecules 2002, 3:232-238.
4. Huang Z.M., Zhang Y.Z., Ramakrishna S., Lim C.T. Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 2004, 45:5361-5368.
5. Neal R.A., McClugage S.G., Link M.C., Sefcik L.S., Ogle R.C., Botchwey E.A. Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes. Tissue Eng C 2009, 15:11-21.
6. Ohkawa K., Cha D., Kim H., Nishida A., Yamamoto H. Electrospinning of chitosan. Macromol Rapid Commun 2004, 25:1600-1605.
7. Wang W., Itoh S., Matsuda A., Aizawa T., Demura M., Ichinose S., et al. Enhanced nerve regeneration through a bilayered chitosan tube: the effect of introduction of glycine spacer into the CYIGSR sequence. J Biomed Mater Res A 2008, 85:919-928.
8. Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hata Y., et al. Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. J Biomed Mater Res A 2008, 84:557-566.
9. Lee C.H., Singla A., Lee Y. Biomedical applications of collagen. Int J Pharm 2001, 221:1-22.
10. Chamberlain L.J., Yannas I.V., Hsu H.P., Strichartz G., Spector M. Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol 1998, 154:315-329.
11. Yannas I.V. Tissue and organ regeneration in adults 2001, 10. Springer-Verlag, New York.
12. Spilker M.H., Yannas I.V., Kostyk S.K., Norregaard T.V., Hsu H.P., Spector M. The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord. Restor Neurol Neurosci 2001, 18:23-38.
13. Liu Y., Ramanath H.S., Wang D.A. Tendon tissue engineering using scaffold enhancing strategies. Trends Biotechnol 2008, 26:201-209.
14. Kleinman H.K., McGarvey M.L., Hassell J.R., Star V.L., Cannon F.B., Laurie G.W., et al. Basement membrane complexes with biological activity. Biochemistry 1986, 25:312-318.
15. Keeley R.D., Nguyen K.D., Stephanides M.J., Padilla J., Rosen J.M. The artificial nerve graft: a comparison of blended elastomer-hydrogel with polyglycolic acid conduits. J Reconstr Microsurg 1991, 7:93-100.
16. Corey J.M., Lin D.Y., Mycek K.B., Chen Q., Samuel S., Feldman E.L., et al. Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth. J Biomed Mater Res A 2007, 83:636-645.
17. Patel S., Kurpinski K., Quigley R., Gao H., Hsiao B.S., Poo M.M., et al. Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett 2007, 7:2122-2128.
18. Yang F., Murugan R., Wang S., Ramakrishna S. Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005, 26:2603-2610.
19. Ghasemi-Mobarakeh L., Prabhakaran M.P., Morshed M., Nasr-Esfahani M.H., Ramakrishna S. Electrospun poly(σ-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. Biomaterials 2008, 29:4532-4539.
20. Schnell E., Klinkhammer K., Balzer S., Brook G., Klee D., Dalton P., et al. Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-σ-caprolactone and a collagen/poly-σ-caprolactone blend. Biomaterials 2007, 28:3012-3025.
21. Panseri S., Cunha C., Lowery J., Del Carro U., Taraballi F., Amadio S., et al. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol 2008, 8:39.
22. Davis M.E., Motion J.P., Narmoneva D.A., Takahashi T., Hakuno D., Kamm R.D., et al. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation 2005, 111:442-450.
23. Ellis-Behnke R.G., Liang Y.X., Tay D.K., Kau P.W., Schneider G.E., Zhang S., et al. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomed Nanotechnol Biol Med 2006, 2:207-215.
24. Ellis-Behnke R.G., Liang Y.X., You S.W., Tay D.K., Zhang S., So K.F., et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A 2006, 103:5054-5059.
25. Bawa P., Pillay V., Choonara Y.E., du Toit L.C. Stimuli-responsive polymers and their applications in drug delivery. Biomed Mater 2009, 4:22001.
26. Branco M.C., Pochan D.J., Wagner N.J., Schneider J.P. Macromolecular diffusion and release from self-assembled β-hairpin peptide hydrogels. Biomaterials 2009, 30:1339-1347.
27. Kyle S., Aggeli A., Ingham E., McPherson M.J. Production of self-assembling biomaterials for tissue engineering. Trends Biotechnol 2009, 27:423-433.
28. Elbert D.L., Pratt A.B., Lutolf M.P., Halstenberg S., Hubbell J.A. Protein delivery from materials formed by self-selective conjugate addition reactions. J Control Release 2001, 76:11-25.
29. Mann B.K., Gobin A.S., Tsai A.T., Schmedlen R.H., West J.L. Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials 2001, 22:3045-3051.
30. Koh H.S., Yong T., Chan C.K., Ramakrishna S. Enhancement of neurite outgrowth using nano-structured scaffolds coupled with laminin. Biomaterials 2008, 29:3574-3582.
31. Gelain F., Bottai D., Vescovi A., Zhang S. Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE 2006, e119:1.
32. Lyons J., Li C., Ko F. Melt-electrospinning part I: processing parameters and geometric properties. Polymer 2004, 45:7597-7603.
33. Tan S.H., Inai R., Kotaki M., Ramakrishna S. Systematic parameter study for ultra-fine fiber fabrication via electrospinning process. Polymer 2005, 46:6128-6134.
34. Gersbach C.A., Byers B.A., Pavlath G.K., Guldberg R.E., Garcia A.J. Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. Biotechnol Bioeng 2004, 88:369-378.
35. Shields K.J., Beckman M.J., Bowlin G.L., Wayne J.S. Mechanical properties and cellular proliferation of electrospun collagen type II. Tissue Eng 2004, 10:1510-1517.
36. Bhattarai N., Edmondson D., Veiseh O., Matsen F.A., Zhang M. Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 2005, 26:6176-6184.
37. Geng X., Kwon O.H., Jang J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 2005, 26:5427-5432.
38. Um I.C., Fang D., Hsiao B.S., Okamoto A., Chu B. Electro-spinning and electro-blowing of hyaluronic acid. Biomacromolecules 2004, 5:1428-1436.
39. Jin H.J., Chen J., Karageorgiou V., Altman G.H., Kaplan D.L. Human bone marrow stromal cell responses on electrospun silk fibroin mats. Biomaterials 2004, 25:1039-1047.
40. Jin H.J., Fridrikh S.V., Rutledge G.C., Kaplan D.L. Electrospinning Bombyx mori silk with poly(ethylene oxide). Biomacromolecules 2002, 3:1233-1239.
41. Jin H.J., Park J., Valluzzi R., Cebe P., Kaplan D.L. Biomaterial films of Bombyx mori silk fibroin with poly(ethylene oxide). Biomacromolecules 2004, 5:711-717.
42. Cai J., Peng X., Nelson K.D., Eberhart R., Smith G.M. Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. J Biomed Mater Res A 2005, 75:374-386.
43. Hadlock T., Elisseeff J., Langer R., Vacanti J., Cheney M. A tissue-engineered conduit for peripheral nerve repair. Arch Otolaryngol Head Neck Surg 1998, 124:1081-1086.
44. Luis A.L., Rodrigues J.M., Geuna S., Amado S., Shirosaki Y., Lee J.M., et al. Use of PLGA 90:10 scaffolds enriched with in vitro-differentiated neural cells for repairing rat sciatic nerve defects. Tissue Eng Part A 2008, 14:979-993.
45. Evans G.R., Brandt K., Niederbichler A.D., Chauvin P., Herrman S., Bogle M., et al. Clinical long-term in vivo evaluation of poly(l-lactic acid) porous conduits for peripheral nerve regeneration. J Biomater Sci Polym Ed 2000, 11:869-878.
46. Fairman R., Akerfeldt K.S. Peptides as novel smart materials. Curr Opin Struct Biol 2005, 15:453-463.
47. Zhang S., Holmes T.C., DiPersio C.M., Hynes R.O., Su X., Rich A. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 1995, 16:1385-1393.
48. Taraballi F., Campione M., Sassella A., Vescovi A., Paleari A., Hwang W., et al. Effect of functionalization on the self-assembling propensity of β-sheet forming peptides. Soft Matter 2009, 5:660-668.
49. Taraballi F., Natalello A., Campione M., Villa O., Doglia S.M., Paleari A., et al. Glycine-spacers influence functional motifs exposure and self-assembling propensity of functionalized substrates tailored for neural stem cell cultures. Frontiers Neuroeng 2010, 3:1.
50. Schense J.C., Bloch J., Aebischer P., Hubbell J.A. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol 2000, 18:415-419.
51. Ma P.X., Zhang R. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 1999, 46:60-72.
52. Ma P.X., Zhang R. Microtubular architecture of biodegradable polymer scaffolds. J Biochem Mater Res Part A 2001, 56:469-477.
53. Hua F.J., Kim G.E., Lee J.D., Son Y.K., Lee D.S. Macroporous poly(l-lactide) scaffold 1. Preparation of a macroporous scaffold by liquid-liquid phase separation of a PLLA-dioxane-water system. J Biomed Mater Res 2002, 63:161-167.
54. Yang F., Murugan R., Ramakrishna S., Wang X., Ma Y.X., Wang S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 2004, 25:1891-1900.
55. Chew S.Y., Mi R., Hoke A., Leong K.W. The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. Biomaterials 2008, 29:653-661.
56. Sun Z.C., Zussman E., Yarin A.L., Wendorff J.H., Greiner A. Compound core-shell polymer nanofibers by co-electrospinning. Adv Mater 2003, 15:1929-1932.
57. Zhang Y., Huang Z.M., Xu X., Lim C.T., Ramakrishna S. Preparation of core-shell structured PCL-r-gelatin bi-component nanofibers by coaxial electrospinning. Chem Mater 2004, 16:3406-3409.
58. Desai T.A. Micro- and nanoscale structures for tissue engineering constructs. Med Eng Phys 2000, 22:595-606.
59. Flemming R.G., Murphy C.J., Abrams G.A., Goodman S.L., Nealey P.F. Effects of synthetic micro- and nano-structured surfaces on cell behavior. Biomaterials 1999, 20:573-588.
60. Liu X., Ma P.X. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 2004, 32:477-486.
61. Vleggeert-Lankamp C.L., de Ruiter G.C., Wolfs J.F., Pego A.P., van den Berg R.J., Feirabend H.K., et al. Pores in synthetic nerve conduits are beneficial to regeneration. J Biomed Mater Res A 2007, 80:965-982.
62. Vleggeert-Lankamp C.L., Wolfs J., Pego A.P., van den Berg R., Feirabend H., Lakke E. Effect of nerve graft porosity on the refractory period of regenerating nerve fibers. J Neurosurg 2008, 109:294-305.
63. Madaghiele M., Sannino A., Yannas I.V., Spector M. Collagen-based matrices with axially oriented pores. J Biomed Mater Res A 2008, 85:757-767.
64. Koutsopoulos S., Unsworth L.D., Nagai Y., Zhang S. Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold. Proc Natl Acad Sci U S A 2009, 106:4623-4628.
65. Nagai Y., Unsworth L.D., Koutsopoulos S., Zhang S. Slow release of molecules in self-assembling peptide nanofiber scaffold. J Control Release 2006, 115:18-25.
66. Mazzatenta A., Giugliano M., Campidelli S., Gambazzi L., Businaro L., Markram H., et al. Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits. J Neurosci 2007, 27:6931-6936.
67. Chauhan N.B., Figlewicz H.M., Khan T. Carbon filaments direct the growth of postlesional plastic axons after spinal cord injury. Int J Dev Neurosci 1999, 17:255-264.
68. Elias K.L., Price R.L., Webster T.J. Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials 2002, 23:3279-3287.
69. Khan T., Dauzvardis M., Sayers S. Carbon filament implants promote axonal growth across the transected rat spinal cord. Brain Res 1991, 541:139-145.
70. Pesakova V., Klezl Z., Balik K., Adam M. Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon. J Mater Sci Mater Med 2000, 11:793-798.
71. Galvan-Garcia P., Keefer E.W., Yang F., Zhang M., Fang S., Zakhidov A.A., et al. Robust cell migration and neuronal growth on pristine carbon nanotube sheets and yarns. J Biomater Sci Polym Ed 2007, 18:1245-1261.
72. Lovat V., Pantarotto D., Lagostena L., Cacciari B., Grandolfo M., Righi M., et al. Carbon nanotube substrates boost neuronal electrical signaling. Nano Lett 2005, 5:1107-1110.
73. Cellot G., Cilia E., Cipollone S., Rancic V., Sucapane A., Giordani S., et al. Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. Nat Nanotechnol 2009, 4:126-133.
74. Hummer G., Rasaiah J.C., Noworyta J.P. Water conduction through the hydrophobic channel of a carbon nanotube. Nature 2001, 414:188-190.
75. McKenzie J.L., Waid M.C., Shi R., Webster T.J. Decreased functions of astrocytes on carbon nanofiber materials. Biomaterials 2004, 25:1309-1317.
76. Chew S.Y., Wen J., Yim E.K., Leong K.W. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 2005, 6:2017-2024.
77. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 2004, 98:47-56.
78. Berthiaume F., Moghe P.V., Toner M., Yarmush M.L. Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J 1996, 10:1471-1484.
79. Taipale J., Keski-Oja J. Growth factors in the extracellular matrix. FASEB J 1997, 11:51-59.
80. Liang D., Hsiao B.S., Chu B. Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv Rev 2007, 59:1392-1412.
81. Li C., Vepari C., Jin H.J., Kim H.J., Kaplan D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 2006, 27:3115-3124.
82. Luu Y.K., Kim K., Hsiao B.S., Chu B., Hadjiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release 2003, 89:341-353.
83. Xie J., Willerth S.M., Li X., Macewan M.R., Rader A., Sakiyama-Elbert S.E., et al. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 2009, 30:354-362.
84. Dawson E., Mapili G., Erickson K., Taqvi S., Roy K. Biomaterials for stem cell differentiation. Adv Drug Deliv Rev 2008, 60:215-228.
85. Hwang N.S., Varghese S., Elisseeff J. Controlled differentiation of stem cells. Adv Drug Deliv Rev 2008, 60:199-214.
86. Kokkoli E., Mardilovich A., Wedekind A., Rexeisen E.L., Garg A., Craig J.A. Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles. Soft Matter 2006, 2:1015-1024.
87. Madurantakam P.A., Cost C.P., Simpson D.G., Bowlin G.L. Science of nanofibrous scaffold fabrication: strategies for next generation tissue-engineering scaffolds. Nanomedicine (Lond) 2009, 4:193-206.