Therapeutic potential of some stress mediators in early Alzheimer's disease

Experimental Gerontology

Volumn 46, Issue 2-3, 2011, Pages 170-173

  Pardon, Marie Christine ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

A oligomers; Acetylcholinesterase splice variant; Alzheimer's disease; Amyloid plaques; Corticotrophin releasing hormone; Exercise; Glucocorticoids; Long term potentiation; Stress; Tau hyperphosphorylation

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID; AMYLOID BETA PROTEIN; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; TAU PROTEIN;

AGING; ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; COGNITION; HUMAN; LIFESTYLE; MENTAL PERFORMANCE; NERVE CELL PLASTICITY; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS; SYMPTOMATOLOGY; SYNAPTIC POTENTIAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION; HUMANS; LIFE STYLE; NEUROFIBRILLARY TANGLES; STRESS, PHYSIOLOGICAL; TAU PROTEINS;

EID: 78751701933     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.09.006     Document Type: Article

References (36)

1. Adlard P.A., Perreau V.M., Pop V., Cotman C.W. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci. 2005, 25:4217-4221.
2. 2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 2010, 47:264-272.
3. Arzt E., Holsboer F. CRF signaling: molecular specificity for drug targeting in the CNS. Trends Pharmacol. Sci. 2006, 27:531-538.
4. Bayatti N., Behl C. The neuroprotective actions of corticotropin releasing hormone. Ageing Res. Rev. 2005, 4:258-270.
5. Behan D.P., Khongsaly O., Owens M.J., Chung H.D., Nemeroff C.B., De Souza E.B. Corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), and CRF/CRF-BP complex in Alzheimer's disease and control postmortem human brain. J. Neurochem. 1997, 68:2053-2060.
6. Berson A., Knobloch M., Hanan M., Diamant S., Sharoni M., Schuppli D., Geyer B.C., Ravid R., Mor T.S., Nitsch R.M., Soreq H. Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain 2008, 131:109-119.
7. Blennow K., de Leon M.J., Zetterberg H. Alzheimer's disease. Lancet 2006, 368:387-403.
8. Dube T., Brunson T., Nehlig A., Baram T.Z. Activation of specific neuronal circuits by corticotropin releasing hormone as indicated by c-fos expression and glucose metabolism. J. Cereb. Blood Flow Metab. 2000, 20:1414-1424.
9. Escribano L., Simon A.M., Perez-Mediavilla A., Salazar-Colocho P., Del Rio J., Frechilla D. Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model. BBRC 2009, 379:406-410.
10. Garcia R. Stress, hippocampal plasticity, and spatial learning. Synapse 2001, 40:180-183.
11. Green K.N., Billings L.M., Roozendaal B., McGaugh J.L., LaFerla F.M. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 2006, 26:9047-9056.
12. Harris-White M.E., Chu T., Miller S.A., Simmons M., Teter B., Nash D., Cole G.M., Frautschy S.A. Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo. Neurochem. Int. 2001, 39:435-448.
13. Howland J.G., Wang Y.T. Synaptic plasticity in learning and memory: stress effects in the hippocampus. Prog. Brain Res. 2008, 169:145-158.
14. Ikeda Y., Ishiguro K., Fujita S.C. Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain. FEBS Lett. 2007, 581:891-897.
15. Kang J.E., Cirrito J.R., Dong H., Csernansky J.G., Holtzman D.M. Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity. Proc. Natl. Acad. Sci. USA 2007, 104:10673-10678.
16. Kulstad J.J., McMillan P.J., Leverenz J.B., Cook D.G., Green P.S., Peskind E.R., Wilkinson C.W., Farris W., Mehta P.D., Craft S. Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque. J. Neuropathol. Exp. Neurol. 2005, 64:139-146.
17. Lazarov O., Robinson J., Tang Y.P., Hairston I.S., Korade-Mirnics Z., Lee V.M., Hersh L.B., Sapolsky R.M., Mirnics K., Sisodia S.S. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 2005, 120:701-713.
18. Leem Y.H., Lim H.J., Shim S.B., Cho J.Y., Kim B.S., Han P.L. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. J. Neurosci. Res. 2009, 87:2561-2570.
19. Li W.Z., Li W.P., Yao Y.Y., Zhang W., Yin Y.Y., Wu G.C., Gong H.L. Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice. Eur. J. Pharmacol. 2010, 628:108-115.
20. Mirochnic S., Wolf S., Staufenbiel M., Kempermann G. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus 2009, 10(10):1008-1018.
21. Nijholt I., Farchi N., Kye M., Sklan E.H., Shoham S., Verbeure B., Owen D., Hochner B., Spiess J., Soreq H., Blank T. Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol. Psychiatry 2004, 9:174-183.
22. Nimmrich V., Ebert U. Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid. Rev. Neurosci. 2009, 20:1-12.
23. Parachikova A., Nichol K.E., Cotman C.W. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiol. Dis. 2008, 30:121-129.
24. Pardon M.C. Hormesis is applicable as a pro-healthy aging intervention in mammals and human beings. Dose Response 2009, 8:22-27.
25. Pardon M.C., Rattray I. What do we know about the long-term consequences of stress on ageing and the progression of age-related neurodegenerative disorders?. Neurosci. Biobehav. Rev. 2008, 32:1103-1120.
26. Pardon M.-C., Kendall D.A., Perez-Diaz F., Duxon M.S., Marsden C.A. Repeated sensory contact with aggressive mice rapidly leads to an anticipatory increase in core body temperature and physical activity that precedes the onset of aversive responding. Eur. J. Neurosci. 2004, 20:1033-1050.
27. Pardon M.C., Sarmad S., Rattray I., Bates T.E., Scullion G.A., Marsden C.A., Barrett D.A., Lowe J., Kendall D.A. Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiol. Aging 2009, 30:1099-1113.
28. Rattray I., Scullion G.A., Soulby A., Kendall D.A., Pardon M.C. The occurrence of a deficit in contextual fear extinction in adult amyloid-over-expressing TASTPM mice is independent of the strength of conditioning but can be prevented by mild novel cage stress. Behav. Brain Res. 2009, 200:83-90.
29. Rattray I., Pitiot A., Lowe J., Auer D.P., Lima S.J., Schubert M.I., Prior M.J., Marsden C.A., Diaz F.P., Kendall D.A., Pardon M.C. Novel cage stress alters remote contextual fear extinction and regional T{2} magnetic resonance relaxation times in TASTPM mice overexpressing amyloid. J. Alzheimers Dis. 2010, 20:1-20.
30. Rissman R.A., Lee K.F., Vale W., Sawchenko P.E. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J. Neurosci. 2007, 27:6552-6562.
31. Rosa M.L., Guimaraes F.S., de Oliveira R.M., Padovan C.M., Pearson R.C., Del Bel E.A. Restraint stress induces beta-amyloid precursor protein mRNA expression in the rat basolateral amygdala. Brain Res. Bull. 2005, 65:69-75.
32. Swaab D.F., Bao A.M., Lucassen P.J. The stress system in the human brain in depression and neurodegeneration. Ageing Res. Rev. 2005, 4:141-194.
33. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
34. Walsh D.M., Selkoe D.J. A beta oligomers - a decade of discovery. J. Neurochem. 2007, 101:1172-1184.
35. Yamin G. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. J. Neurosci. Res. 2009, 87:1729-1736.
36. Yao Y.Y., Liu D.M., Xu D.F., Li W.P. Memory and learning impairment induced by dexamethasone in senescent but not young mice. Eur. J. Pharmacol. 2007, 574:20-28.