Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans

Medicina Oral, Patologia Oral y Cirugia Bucal

Volumn 16, Issue 1, 2011, Pages

  Calamari, Silvia Edith ^a   Bojanich, María Alejandra ^a   Barembaum, Silvina Ruth ^a   Berdicevski, Nora ^a   Azcurra, Ana Isabel ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Antifungal effect; Candida albicans; Chitosan; Chlorhexidine; Fluconazole

Indexed keywords

CHITOSAN; CHLORHEXIDINE; FLUCONAZOLE; PHOSPHOLIPASE; VIRULENCE FACTOR;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL SURFACE; DRUG EFFECT; ENZYME ACTIVITY; FUNGAL STRAIN; HYDROPHOBICITY; NONHUMAN; THRUSH;

ANTI-INFECTIVE AGENTS, LOCAL; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CHITOSAN; CHLORHEXIDINE; FLUCONAZOLE; HUMANS;

EID: 78751659209     PISSN: 16984447     EISSN: 16986946     Source Type: Journal    
DOI: 10.4317/medoral.16.e23     Document Type: Article

References (29)

1. Lopez-De-Blanc SA, Salati-De-Mugnolo N, Femopase FL, Benitez MB, Morelatto RA, Astrada-De-Verde L, et al. Antifungal topical therapy in oral chronic candidosis. A comparative study. Med Oral. 2002;7:260-70.
2. Kliemann DA, Pasqualotto AC, Falavigna M, Giaretta T, Severo LC. Candida esophagitis: species distribution and risk factors for infection. Rev Inst Med Trop Sao Paulo. 2008;50:261-3.
3. Azcurra AI, Barembaum SR, Bojanich MA, Calamari SE, Aguilar J, Battellino LJ, et al. Effect of the high molecular weight chitosan and sodium alginate on Candida albicans hydrophobicity and adhesion to cells. Med Oral Patol Oral Cir Bucal. 2006;11:E120-5.
4. Baena-Monroy T, Moreno-Maldonado V, Franco-Martínez F, Aldape- Barrios B, Quindós G, Sánchez-Vargas LO. Candida albicans, Staphylococcus aureus and Streptococcus mutans colonization in patients wearing dental prosthesis. Med Oral Patol Oral Cir Bucal. 2005;10 Suppl 1:E27-39.
5. Singleton DR, Masuoka J, Hazen KC. Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants. Eukaryot Cell. 2005;4:639-48.
6. Vidotto V, Yumi Koga-Ito C, Milano R, Fianchino B, Pontón J. Correlation between germ tube production, phospholipase activity and serotype distribution in Candida albicans. Rev Iberoam Micol. 1999;16:208-10. (Pubitemid 30048613)
7. Kadir T, Gümrü B, Uygun-Can B. Phospholipase activity of Candida albicans isolates from patients with denture stomatitis: the influence of chlorhexidine gluconate on phospholipase production. Arch Oral Biol. 2007;52:691-6.
8. Egusa H, Ellepola AN, Nikawa H, Hamada T, Samaranayake LP. Sub-therapeutic exposure to polyene antimycotics elicits a post-antifungal effect (PAFE) and depresses the cell surface hydrophobicity of oral Candida albicans isolates. J Oral Pathol Med. 2000;29:206-13.
9. Denning DW, Hope WW. Therapy for fungal diseases: opportunities and priorities. Trends Microbiol. 2010;18:195-204.
10. Barasch A, Safford MM, Dapkute-Marcus I, Fine DH. Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:204-7.
11. Navarathna DH, Hornby JM, Hoerrmann N, Parkhurst AM, Duhamel GE, Nickerson KW. Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. J Antimicrob Chemother. 2005;56:1156-9.
12. Lyon JP, De Resende MA. Correlation between adhesion, enzyme production, and susceptibility to fluconazole in Candida albicans obtained from denture wearers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:632-8.
13. Koide SS. Chitin-chitosan: properties, benefits and risks. Nutrition Research. 1998;18:1091-101.
14. Barembaum S, Virga C, Bojanich A, Cornejo L, Calamari S, Pontón J, et al. Effect of Chitosan and Sodium Alginate on the adherence of autochthonous C. Albicans to oral epithelial cells (in vitro). Med Oral. 2003;8:188-96.
15. Rossi S, Sandri G, Ferrari F, Bonferoni MC, Caramella C. Buccal delivery of acyclovir from films based on chitosan and polyacrylic acid. Pharm Dev Technol. 2003;8:199-208.
16. Calamari S, Bojanich A, Barembaum S, Azcurra A, Virga C, Dorronsoro S. [High molecular weight chitosan and sodium alginate effect on secretory acid proteinase of Candida albicans]. Rev Iberoam Micol. 2004;21:206-8.
17. Seyfarth F, Schliemann S, Elsner P, Hipler UC. Antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-D-glucosamine against Candida albicans, Candida krusei and Candida glabrata. Int J Pharm. 2008;353:139-48.
18. García-Martos P, García-Agudo R, Hernández-Molina JM, Marín P, Tallero E, Mira J. [Identification of yeasts of clinical interest on CHROMagar Candida culture medium.]. Rev Iberoam Micol. 1998;15:131-5.
19. Carrillo-Muñoz AJ, Quindós G, Ruesga M, Alonso R, Del Valle O, Hernández-Molina JM, et al. Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections. J Antimicrob Chemother. 2005;55:317-9.
20. Anil S, Ellepola AN, Samaranayake LP. The impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicans. Oral Dis. 2001;7:119-22. (Pubitemid 32318829)
21. Yoshida T, Jono K, Okonogi K. Modified agar dilution susceptibility testing method for determining in vitro activities of antifungal agents, including azole compounds. Antimicrob Agents Chemother. 1997;41:1349-51.
22. Ellepola AN, Samaranayake LP. The effect of brief exposure to sub-therapeutic concentrations of chlorhexidine gluconate on the germ tube formation of oral Candida albicans and its relationship to post-antifungal effect. Oral Dis. 2000;6:166-71.
23. Goldberg S, Doyle RJ, Rosenberg M. Mechanism of enhancement of microbial cell hydrophobicity by cationic polymers. J Bacteriol. 1990;172:5650-4.
24. Hube B, Stehr F, Bossenz M, Mazur A, Kretschmar M, Schäfer W. Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Arch Microbiol. 2000;174:362-74.
25. Masuoka J, Hazen KC. Cell wall mannan and cell surface hydrophobicity in Candida albicans serotype A and B strains. Infect Immun. 2004;72:6230-6.
26. Senel S, Ikinci G, Kaş S, Yousefi-Rad A, Sargon MF, Hincal AA. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm. 2000;193:197-203.
27. Giunchedi P, Juliano C, Gavini E, Cossu M, Sorrenti M. Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur J Pharm Biopharm. 2002;53:233-9.
28. Ellepola AN, Samaranayake LP. Adjunctive use of chlorhexidine in oral candidoses: a review. Oral Dis. 2001;7:11-7.
29. Pinto E, Ribeiro IC, Ferreira NJ, Fortes CE, Fonseca PA, Figueiral MH. Correlation between enzyme production, germ tube formation and susceptibility to fluconazole in Candida species isolated from patients with denture-related stomatitis and control individuals. J Oral Pathol Med. 2008;37:587-92.