Polymorphisms in IL10 are associated with total Immunoglobulin e levels and Schistosoma mansoni infection intensity in a Brazilian population

Genes and Immunity

Volumn 12, Issue 1, 2011, Pages 46-50

  Grant, A V ^a,b   Araujo, M I ^c   Ponte, E V ^d   Oliveira, R R ^c   Cruz, A A ^c,d   Barnes, K C ^a,b   Beaty, T H ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Hospital Universitario   (Brazil)

^d FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

atopy; genetic susceptibility; IgE; IL 10; promoter polymorphism; schistosomiasis

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 10;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BRAZIL; CHILD; CLINICAL ASSESSMENT; EXON; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HOST RESISTANCE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PARASITE IDENTIFICATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS; SCHISTOSOMIASIS MANSONI; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TH2 CELL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BRAZIL; CHILD; FEMALE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-10; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; YOUNG ADULT;

SCHISTOSOMA MANSONI;

EID: 78751650558     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2010.50     Document Type: Article

References (29)

1. King CH, Dickman K, Tisch DJ. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 2005; 365: 1561-1569.
2. Quinnell RJ. Genetics of susceptibility to human helminth infection. Int J Parasitol 2003; 33: 1219-1231.
3. Caldas IR, Campi-Azevedo AC, Oliveira LF, Silveira AM, Oliveira RC, Gazzinelli G. Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection. Acta Trop 2008; 108: 109-117.
4. Pearce EJ, MacDonald AS. The immunobiology of schistoso-miasis. Nat Rev Immunol 2002; 2: 499-511.
5. Belkaid Y, Blank RB, Suffia I. Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev 2006; 212: 287-300.
6. Robinson DS, Larche M, Durham SR. Tregs and allergic disease. J Clin Invest 2004; 114: 1389-1397.
7. Alves Oliveira LF, Moreno EC, Gazzinelli G, Martins-Filho OA, Silveira AM, Gazzinelli A et al. Cytokine production associated with periportal fibrosis during chronic schistoso-miasis mansoni in humans. Infect Immun 2006; 74: 1215-1221.
8. De Morais CN, Rodrigues de Souza J, Gomes de Melo W, Aroucha ML, Domingues AL, Wynn T et al. Studies on the production and regulation of interleukin, IL-13, IL-4 and interferon-gamma in human Schistosomiasis mansoni. Mem Inst Oswaldo Cruz 2002; 97(Suppl 1): 113-114.
9. Silva-Teixeira DN, Contigli C, Lambertucci JR, Serufo JC, Rodrigues Jr V. Gender-related cytokine patterns in sera of schistosomiasis patients with Symmers' fibrosis. Clin Diagn Lab Immunol 2004; 11: 627-630.
10. De Jesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, de Jesus AA et al. Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection. Infect Immun 2004; 72: 3391-3397.
11. Capron A, Dombrowicz D, Capron M. Helminth infections and allergic diseases: from the th2 paradigm to regulatory networks. Clin Rev Allergy Immunol 2004; 26: 25-34.
12. Van den Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG et al. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 2000; 356: 1723-1727.
13. Araujo MI, Hoppe B, Medeiros Jr M, Alcantara L, Almeida MC, Schriefer A et al. Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma. J Infect Dis 2004; 190: 1797-1803.
14. Lynch NR, Hagel I, Perez M, Di Prisco MC, Lopez R, Alvarez N. Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum. J Allergy Clin Immunol 1993; 92: 404-411. (Pubitemid 24088692)
15. Medeiros Jr M, Figueiredo JP, Almeida MC, Matos MA, Araujo MI, Cruz AA et al. Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol 2003; 111: 947-951.
16. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006; 7: 95-100.
17. Bethony JM, Quinnell RJ. Genetic epidemiology of human schistosomiasis in Brazil. Acta Trop 2008; 108: 166-174.
18. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24: 1-8.
19. Grant AV, Araujo MI, Ponte EV, Oliveira RR, Cruz AA, Barnes KC et al. High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population. J Infect Dis 2008; 198: 1227-1236.
20. Azevedo ES. Subgroup studies of black admixture within a mixed population of Bahia, Brazil. Ann Hum Genet 1980; 44 (Part 1): 55-60.
21. Katz N, Coelho PM, Pellegrino J. Evaluation of Kato's quantitative method through the recovery of Schistosoma mansoni eggs added to human feces. J Parasitol 1970; 56: 1032-1033.
22. Katz N, Zicker F, Rocha RS, Oiveira VB. Reinfection of patients in schistosomiasis mansoni endemic areas after specific treatment. Rev Inst Med Trop Sao Paulo 1978; 20: 273-278.
23. De Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217-1223.
24. International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437: 1299-1320.
25. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al. The structure of haplotype blocks in the human genome. Science 2002; 296: 2225-2229.
26. Eichenbaum-Voline S, Baur MP, Knapp M. Genetic analysis of a complex disease in the presence of an environmental risk factor. Genet Epidemiol 1999; 17(Suppl 1): S545-S550.
27. Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT et al. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 2001; 25: 377-384.
28. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.
29. Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 1998; 158: 1958-1962.