Influence of pKa on the biotransformation of indene H 1-antihistamines by CYP2D6

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 947-951

  Huang, Charles ^a   Moree, Wilna J ^a   Zamani Kord, Said ^a   Li, Bin Feng ^a   Tucci, Fabio C ^a   Malany, Siobhan ^a   Wen, Jianyun ^a   Wang, Hua ^a   Hoare, Samuel R J ^a   Yang, Chun ^a   Madan, Ajay ^a   Crowe, Paul D ^a   Beaton, Graham ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Biotransformation; CYP2D6; H1 receptor; H1 antihistamine; Histamine; Indene; Insomnia; pKa

Indexed keywords

ANTIHISTAMINIC AGENT; CYTOCHROME P450 2D6; HISTAMINE H1 RECEPTOR ANTAGONIST; INDENE DERIVATIVE; HISTAMINE H1 RECEPTOR; PYRAZINE DERIVATIVE;

ARTICLE; BIOTRANSFORMATION; DRUG METABOLISM; IN VITRO STUDY; PKA; STRUCTURE ACTIVITY RELATION; CHEMISTRY; METABOLISM; SYNTHESIS;

BIOTRANSFORMATION; CYTOCHROME P-450 CYP2D6; HISTAMINE H1 ANTAGONISTS; INDENES; PYRAZINES; RECEPTORS, HISTAMINE H1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78751648539     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.053     Document Type: Article

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