Use of short term genotoxicological tests to study cytotoxic, genotoxic and cell death mechanism of Metronidazole

Latin American Journal of Pharmacy

Volumn 29, Issue 8, 2010, Pages 1319-1327

  López Nigro, Marcela M ^a   Mudry, Marta D ^b   Carballo, Marta A ^a  

^a University of Buenos Aires   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cell death; Cytotoxicity; Genetic toxicology; Genotoxicity; Metronidazole; Short term tests

Indexed keywords

METRONIDAZOLE;

ADULT; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CHROMOSOME ABERRATION; CHROMOSOME REPLICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIPLOIDY; DNA CONTENT; DNA STRUCTURE; DRUG CYTOTOXICITY; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MITOSIS INHIBITION; SISTER CHROMATID EXCHANGE; TOXICITY TESTING;

EID: 78751638338     PISSN: 03262383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Freeman, C.D., N.E. Klutman, & K.C.Lamp (1997) Drugs 54: 679-708.
2. Thapa, P.B., J.A. Whitlock, K.G. Brockman Worrell, P. Gideon, E.F. Mitchel Jr, P. Roberson, Pais R & W.A. Ray (1998) Cancer 83: 1461-8.
3. World Health Organization, Essential Drugs (1999) WHO Drug Information 13: 249-62.
4. Sisson, G., J.Y. Jeong, A. Goodwin, L Bryden., N. Rossler, S. Lim-Morrison, A. Raudonikiene, D.E. Berg & P.S. Hoffman (2000) J. Bacteriol. 182: 5091-6.
5. Dobías, L., M. Cerná, P. Rösner & R. Srám (1994) Mutat. Res. 317: 177-94.
6. Mudry, M.D., I. Martínez-Flores, A.M. Palermo, M.A. Carballo, J. Egozcue & M.Garcíacaldés (2001) Teratog. Carcinog. Mutag. 21: 197-205.
7. Tocher, J.H. & D.I. Edwards (1994) Biochem. Pharmacol. 48: 1089-94.
8. Reitz, M., M. Rumpf & R. Knitza (1991) Arzneimit-telforschung 41: 155-6.
9. Reitz, M., M. Rumpf & R. Knitza (1991) Drug Res. 41: 65-9.
10. Edwards, D,I. (1993) J. Antibiot. Chemother. 31: 9-20.
11. Trinh, S. & G. Rysset (1998) Mutat. Res. 398: 55-65.
12. Espinosa-Aguirre, J.J., R.A. I. de la Torre, Lares-Asseff, J. Rubio, V. Dorado, M. Wong & J.M. Hernández (1996) Mutat. Res. 359: 133-40.
13. Bendesky, A., D. Menéndez & P Ostrosky-Wegman (2002) Mutat. Res. 511: 133-44.
14. IARC (International Agency for Research on Cancer), Monographs on the Evaluation of Carcinogenic Risk to Humans (1987). Suppl. 7: Overall Evaluations of Carcinogenicity: An updating of IARC Monographs Volumes 1 to 42. International Agency for Research on Cancer, Lyon, France, pp. 250-52.
15. El-Nahas, A.F. & I.M. El-Ashmawy (2004) Pharmacol. & Toxicol. 94: 226-31.
16. Tucker, J.D.; R.J Preston (1996) Mutat. Res. 365: 147-59.
17. Rajewsky, M.F., J. Engelbergs, J. Thomale & T. Schweer (2000) Mutat. Res. 462: 101-05.
18. Green, D.R. & J.C. Reed (1998) Science 281: 1309-12.
19. Medlineplus (2001) National Library of Medicine. Drug Information. Available at http://www.nlm.nih.gov/medlineplus/druginfo/.
20. Martindale, W. (1993) ';Antiprotozoal agents';, in ';The Extra Pharmacopoeia';, (JEF Reynolds, ed.), The Pharmaceutical Press, London, pp. 516-23.
21. PR Vademecum on-line Argentina (2007) Available at http://www.prvademecum.com/.
22. Carballo, M.A., M. Mudry, I. Larripa, E. Villamil & M. D'Aquino (1992) Mutat. Res. 279: 245-253.
23. Perry, P. & S. Wolff (1974) Nature (London) 261: 156-61.
24. Rojas, E., L.A. Herrera, M. Sordo M.E., Gonsebatt, R. Montero, R. Rodríguez & P. Ostrosky-Wegman (1993) Anti-Cancer Drugs 4: 637-40.
25. IPCS/International Program on Chemical Safety (1985) Environmental Health Criteria 46. Guidelines for the Study of Genetic Effects in Human Populations. WHO, Geneva, pp. 45-54.
26. Aw, T.Y., P. Nicotera, L. Manzo & S. Orrenius (1990) Arch. Biochem. Biophys. 283: 46-50.
27. Cohen, J.J. & R.C. Duke (1992) Apoptosis Annu. Rev. Immunol. 10: 267-93.
28. Hotz, M.A., J. Gong & F. Traganos (1994) Cytometry 15: 237-44.
29. Nicoletti, I., G. Migliorati, M.C. Pagliacci, F. Grignani & C. Riccardi (1991) J. Immunol. Methods 139: 271-80.
30. López Nigro, M.M., A.M. Palermo, M.D. Mudry & M.A. Carballo (2003) Toxicol. in Vitro 17: 35-40.
31. Swierenga, S., J. Heddle, D. Sigal, J. Gilman, R. Brillinger, G. Douglas & E. Nestmann (1991) Mutat. Res. 246: 301-22.
32. Horváthová, E., D. Slamenová, L. Hlincíková, T.K. Mandal, A. Gábelová & A.R. Collins (1998) Mutat. Res. 409: 163-71.
33. Mudry, M.D., M.A. Carballo, M.Labal de Vinuesa, M. Gonzálezcid & I. Larripa (1994) Mutat. Res. 305: 127-32.
34. Martelli, A., A. Allaven, L. Robbiano, F. Mattioli & B. Giovanni (1990) Pharmacol. Toxicol. 66: 329-34.
35. Palermo, A.M., A.S. Reynoso, M. López Nigro, M.D. Mudry & M.A. Carballo (2004) Birth Defects Res. A: Clin. Mol. Teratol. 70: 157-62.
36. Mudry, M.D., A.M. Palermo., S. Merani & M.A. Carballo (2007) Reproductive Toxicol. 23: 246- 252.
37. Carballo, M.A., A.M. Palermo & M.D. Mudry (2004) Ann. Trop. Med. Parasitol. 98: 139-47.
38. Ré, J.L., M.P. De Méo, M. Laget, H. Guiraud, M. Castegnaro, P. Vanelle & G. Duménil (1997) Mutat. Res. 375: 147-55.
39. Nagai, F., Y. Hiyoshi, K. Sugimachi & H. Tamura (2002) Biol. Pharm. Bull. 25: 383-5.
40. Kravtsov, V.D., T.O. Daniel & Koury M.J. (1999) Am. J. Pathol. 155: 1327-39.
41. Brezden, C.B., R.A. McClelland & A.M. Rauth (1997) Br. J. Cancer 76: 18088.
42. Lecoeur, H. (2002) Exp. Cell Res. 277: 1-14.
43. Nasirudeen, A.M.A., Y.E. Hian, M. Singh & K.S.W. Tan (2004) Microbiology 150: 33-43.