Metronidazole-induced alterations in murine spermatozoa morphology

Reproductive Toxicology

Volumn 23, Issue 2, 2007, Pages 246-252

  Mudry, Marta D ^a,e   Palermo, Ana M ^a,b   Merani, María S ^c,e   Carballo, Marta A ^d  

^a Facultad de Ciencias Exactas y Naturales (FCEyN)   (Argentina)

^b Instituto de Investigaciones Cientificas y Tecnicas de Las Fuerzas Armadas   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d Facultad de Farmacia y Bioquimica   (Argentina)

^e Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

CFW male mice; Human therapeutic dose; Metronidazole (MTZ); Seminiferous epithelium cycle; Spermatozoa morphology

Indexed keywords

METRONIDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL CYCLE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIUM CELL; FERTILIZATION; MALE; MALE FERTILITY; MORPHOLOGICAL TRAIT; MOUSE; MULTIPLE MALFORMATION SYNDROME; NONHUMAN; PACHYTENE; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOZOON; SPERMATOZOON TAIL;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL COUNT; FERTILITY; MALE; METRONIDAZOLE; MICE; MICE, INBRED STRAINS; PACHYTENE STAGE; SEMINIFEROUS TUBULES; SPERMATIDS; SPERMATOZOA;

ANIMALIA; MURINAE; MUS;

EID: 33846866082     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.11.010     Document Type: Article

References (51)

1. Freeman C.D., Klutman N.E., and Lamp K.C. Metronidazole-a therapeutic review and update. Drugs 54 (1997) 679-708
2. Mudry M.D., Carballo M.A., Labal de Vinuesa M.D., González Cid M., and Larripa I. Mutagenic bioassay of certain pharmacological drugs: III. Metronidazole (MTZ). Mutation Res 86 (1994) 243-277
3. Mudry M.D., Gadano A., González M., and Carballo M. Mutagénesis química: riesgo y beneficio en el consumo de antiparasitarios. Interciencia 20 4 (1995) 204-211
4. Rodriguez Ferreiro G., Cancino Badías L., López-Nigro M., Palermo A.M., Mudry M.D., Prieto González E., et al. DNA Single strand breaks in peripheral blood lymphocytes induced by three nitroimidazole derivatives. Toxicol Lett 132 (2002) 109-115
5. López Nigro M., Palermo A.M., Mudry M.D., and Carballo M.A. Cytogenetic evaluation of two nitroimidazole derivatives. Toxicol In Vitro 17 (2003) 35-40
6. Carballo M.A., Palermo A.M., and Mudry M.D. Toxicogenetic evaluation of metronidazole in the treatment of women infected with Trichomona vaginalis. Ann Trop Med Parasitol 98 2 (2004) 139-147
7. Dobias L., Cerná M., Rosner P., and Srám R. Genotoxicity and carcinogenicity of metronidazole. Mutat Res 317 (1994) 177-194
8. Mudry M.D., Martinez Flores I., Palermo A.M., Carballo M.A., Egozcue J., and García-Caldés M. Embrioletality induced by metronidazole (MTZ) in Rattus norvegicus. Teratogen Carcinogen Mutagen 21 (2001) 197-205
9. Palermo A.M., Reynoso A.S., López Nigro M., Carballo M.A., and Mudry M.D. Teratogenic evaluation of metronidazole and ornidazole using Drosophila melanogaster as an experimental model. Birth Defects Res (Part A) 70 (2004) 157-162
10. Diav-Citrin O., Shechtman S., Gotteiner T., Arnon J., and Ornoy A. Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study. Teratology 63 5 (2001) 186-192
11. Kazy Z., Puho E., and Czeizel A.E. Teratogenic potential of vaginal metronidazole treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol 123 2 (2005) 174-178
12. Williams K., McKinnell C., Saunders P.T.K., Walker M., Fisher J.S., Turner K.S., et al. Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man. Hum Reprod Update 7 3 (2001) 236-247
13. Saradha B., and Mathur P.P. Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol 21 (2006) 34-41
14. Leblond C.P., and Clermont Y. Spermiogenesis of mouse, rat, hamster, and guinea pigs revealed by the "periodic acid-fuschsin sulphurus acid" technic. Am J Anat 90 (1952) 167-215
15. Oakberg E.F. Duration of spematogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat 99 (1956) 319-409
16. Oakberg E.F. A description of spermiogenesis in the mouse and its use in an analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am J Anat 99 (1956) 507-516
17. Sommer R.J., Ippolito D.L., and Peterson R.E. In utero and lactation exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxine: decrease epididymal and ejaculated sperm number without alterations in sperm transit rate. Toxicol Appl Pharmacol 140 (1996) 146-153
18. Howell W.M., and Black D. Controlled silver-staining of nucleolus organizer regions with a protective colloidal developer: a 1-step method. Experientia 36 (1980) 1014-1015
19. Wyrobek A.J. Methods for evaluating the effects of environmental chemicals on human sperm production. Environ Health Perspect 48 (1983) 53-59
20. Bruce W.R., Furrer F., and Wyrobek A.J. Abnormalities in the shape of murine sperm after acute testicular X-radiation. Mutat Res 23 (1974) 381-386
21. Yang S., Han X., Wei C., Chen J., and Yin D. The toxic effects of pentaclorophenol on rat Sertoli cells in vitro. Environ Toxicol Pharmacol 20 (2005) 182-187
22. McClain R.M., Dowing J.C., and Edgcomb J.E. Effect of metronidazole on fertility and testicular function in male rats. Fundam Appl Toxicol 12 3 (1989) 386-396
23. Grover J.K., Vats V., Srinivas M., Das S.N., Jha P., Gupta D.K., and Mitra D.K. Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats. Indian J Exp Biol 39 11 (2001) 1160-1162
24. El-Nahas AF, El-Ashmawy. Reproductive and cytogenetic toxicity of metronidazole in male mice. Basic Clin Pharmacol Toxicol 2004;94:226-37.
25. Linder R.E., Strader L.F., Slott V.L., and Suarez J.D. Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants. Reprod Toxicol 6 (1992) 491-505
26. McClain R.M., Downing J.C., and Edgcomb J.E. Effect of metronidazole on fertility and testicular function in rats. Fundam Appl Toxicol 12 (1989) 386-396
27. Joshi S.C., Mathur R., Gajraj A., and Sharma T. Influence of methyl parathion on reproductive parameters in male rats. Environ Toxicol Pharmacol 14 (2003) 91-98
28. Bustos Obregón E., and González-Hormazabal P. Mice testicular damage elicited by malathion. Int J Morphol 21 2 (2003) 155-159
29. Khan P.K., and Sinha S.P. Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and mancozeb). Mutagenesis 11 1 (1996) 33-36
30. Hemavathi E., and Rahiman M.A. Toxicological effects of ziram, thiram and diethane M-45 assed by sperm shape abnormalities in mice. J Toxicol Environ Health 38 4 (1993) 393-398
31. Biswas S.J., Pathak S., and Khuda-Bukhsh A.R. Assessment of the genotoxic and cytotoxic potential of anti-epileptic drug, phenobarbital, in mice: a time course study. Mutat Res 563 (2004) 1-11
32. Hugenholtz A.P., and Bruce W.R. Radiation induction of mutations affecting sperm morphology in mice. Mutat Res 107 1 (1983) 177-185
33. Apostoli P., Kiss P., Porru S., Bonde J.P., and Vanhoorne M. Male reproductive toxicity of lead in animals and humans. Occup Environ Med 55 6 (1998) 364-374
34. Mamina V.P., and Sheiko L.D. Effects of ionizing radiation and xenobiotics of the spermatogenic epithelium of laboratory animals. Gig Sanit 6 (2001) 24-27
35. Li H., Chen Q., Yao W., Li L., Shi X., Wang L., et al. Effect of Cr(VI) exposure on sperm quality: human and animal studies. Ann Occup Hyg 45 7 (2001) 505-511
36. Ellis M.K., Richardson A.G., Foster J.R., Smith F.M., Widdowson P.S., Farnworth M.J., et al. The reproductive toxicity of molinate and metabolites to the male rat: Effects on testosterone and sperm morphology. Toxicol Appl Pharmacol 151 1 (2002) 22-32
37. Dauwe T., Janssens E., Kempenaers B., and Eens M. The effect of heavy metal exposure on egg size, eggshell thickness and the number of spermatozoa in blue tit Parus caeruleus eggs. Environ Pollut 129 (2004) 125-129
38. Sutkeviciene N., Andersson M.A., Zilinskas H., and Andersson M. Assessment of boar semen quality in relation to fertility with special reference to methanol stress. Theriogenology 63 (2005) 739-747
39. Guo C., Lu Y., and Wang Hsu G. The influence of aluminum exposure on male reproduction and offspring in mice. Environ Toxicol Pharmacol 20 (2005) 135-141
40. Elizondo G., Gonsebatt M.E., Salazar A.M., Lares I., Santiago P., Herrera J., et al. Genotoxic effects of metronidazole. Mutat Res 370 (1996) 75-80
41. Fahrig R., and Engelke M. Reinvestigation of in vivo genotoxicity studies in man. I. No induction of DNA strand breaks in peripheral blood lymphocytes after metronidazole therapy. Mutat Res 395 (1997) 215-221
42. Foote R.H. Effects of metronidazole, ipronidazole and dibromochloropropane on rabit and human sperm motility and fertility. Reprod Toxicol 16 (2002) 749-755
43. Burrel V.R., Yanagimachi R., and Whitten W.K. Normal mice develop from oocytes injected with spermatozoa with grossly misshapen heads. Biol Reprod 52 (1995) 709-720
44. Ali-Hassan N.H. Miconazole genotoxicity in mice. J Appl Toxicol 17 5 (1997) 313-319
45. Otubanjo O.A., and Mosuro A.A. An in vitro evaluation of abnormal sperm morphology by some anthelmintic drugs in mice. Mutat Res 497 1-2 (2001) 131-138
46. Lee J.D., Kamiguchi Y., and Yanagimachi R. Analysis of chromosome constitution of human spermatozoa with normal and aberrant head morphologies after injection into mouse oocytes. Hum Reprod 11 (1996) 1942-1946
47. Kahraman S., Akarsu C., Cengiz G., Dirican K., Sözen E., Belgin C., et al. Fertility of ejaculated and testicular megalohead spermatozoa with intracytoplasmic sperm injection. Hum Reprod 14 (1999) 726-730
48. Kishikawa H., Tateno H., and Yanagimachi R. Chromosome analysis of BALB/c mouse spermatozoa with normal and abnormal head morphology. Biol Reprod 61 3 (1999) 809-812
49. Vegetti W., Van Assche E., and Frias A. Correlation between sperm parameters and sperm aneuploidy rates investigated by fluorescence in-situ hybridization in infertile men. Hum Reprod 15 (2000) 351-365
50. Viville S., Mollard R., Bach M.L., Falquet C., Gerlinger P., and Warten S. Do morphological anomalies reflect chromosomal aneuploidies? A case report. Hum Reprod 15 (2000) 351-365
51. Re J.L., De Méo M.P., Laget M., Guiraud H., Castegnaro M., Vanelle P., et al. Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay. Mutat Res 375 (1997) 147-155