Refractory hypotension from massive bupropion overdose successfully treated with extracorporeal membrane oxygenation

Pediatric Emergency Care

Volumn 27, Issue 1, 2011, Pages 43-45

  Shenoi, Asha N ^a   Gertz, Shira J ^a   Mikkilineni, Sushmita ^a   Kalyanaraman, Meena ^a  

^a CHILDREN S HOSPITAL OF NEW JERSEY   (United States)

Author keywords

aspiration pneumonia; Bupropion; ECMO; hypotension; seizures

Indexed keywords

ADRENALIN; AMFEBUTAMONE; DOPAMINE; NORADRENALIN;

ANAMNESIS; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; DISEASE COURSE; DISEASE SEVERITY; EXTRACORPOREAL OXYGENATION; FOLLOW UP; HOSPITAL DISCHARGE; HUMAN; HYPOTENSION; INFANT; MALE; METABOLIC ACIDOSIS; RESPIRATORY FAILURE; SEIZURE; TREATMENT OUTCOME;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BLOOD PRESSURE; BUPROPION; EXTRACORPOREAL MEMBRANE OXYGENATION; FOLLOW-UP STUDIES; HUMANS; HYPOTENSION; INFANT; MALE; OVERDOSE;

EID: 78751631771     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e3182045f76     Document Type: Article

References (21)

1. Horst WD, Preskorn SH. Mechanisms of action and clinical characteristics of three atypical antidepressants. Venlafaxine, nefazodone, bupropion. J Affect Disord. 1998;51(3):237Y254.
2. Gobbi G, Slater S, Boucher N, et al. Neurochemical and psychotropic effects of bupropion in healthy male subjects. J Clin Psychopharmacol. 2003;23(3):233Y239.
3. Spiller HA, Schaeffer SE. Multiple seizures after bupropion overdose in a small child. Pediatr Emerg Care. 2008;24(7):474Y475.
4. Wellbutrin X. Research Triangle Park, NC: GlaxoSmithKline; 2006.
5. Balit CR, Lynch CN, Isbister GK. Bupropion poisoning: a case series. Med J Aust. 2003;178(2):61Y63.
6. Spiller HA, Ramoska EA, Krenzelok EP, et al. Bupropion overdose: a 3-year multi-center retrospective analysis. Am J Emerg Med. 1994;12(1):43Y45.
7. Curry SC, Kashani JS, LoVecchio F, et al. Intraventricular conduction delay after bupropion overdose. J Emerg Med. 2005;29(3):299Y305.
8. Givens ML, Gabrysch J. Cardio toxicity associated with accidental bupropion ingestion in a child. Pediatr Emerg Care. 2007;23(4):234Y237.
9. Harris CR, Gualtieri J, Stark G. Fatal bupropion overdose. J Toxicol Clin Toxicol. 1997;35(3):321Y324.
10. Friel PN, Logan BK, Fligner CL. Three fatal drug overdosesinvolving bupropion. J Anal Toxicol. 1993;1 7(7):436Y438.
11. Mercerolle M, Denooz R, Lachatre G, et al. A fatal case of bupropion (Zyban) overdose. J Anal Toxicol. 2008;32(2):192Y196.
12. Weinberg GL, Ripper R, Murphy P, et al. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med. 2006;31(4):296Y303.
13. Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology. 1998;88(4): 1071Y1075.
14. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51(4):412Y415.
15. Goodwin DA, Lally KP, Null DM Jr. Extracorporeal membrane oxygenation support for cardiac dysfunction from tricyclic antidepressant overdose. Crit Care Med. 1993;21(4):625Y627.
16. Williams JM, Hollingshed MJ, Vasilakis A, et al. Extracorporeal circulation in the management of severe tricyclic antidepressant overdose. Am J Emerg Med. 1994;12(4):456Y458.
17. Auzinger GM, Scheinkestel CD. Successful extra corporeal life support in a case of severe flecainide intoxication. Crit Care Med. 2001;29(4):887Y890.
18. Durward A, Guerguerian AM, Lefebvre M, et al. Massive diltiazem overdose treated with extra corporeal membrane oxygenation. Pediatr Crit Care Med. 2003;4(3):372Y376.
19. Kolcz J, Pietrzyk J, Januszewska K, et al. Extracorporeal life support in severe propranolol and verapamil intoxication. J Intensive Care Med. 2007;22(6):381Y385.
20. Marciniak KE, Thomas IH, Brogan TV, et al. Massive ibuprofen overdose requiring extra corporeal membrane oxygenation for cardiovascular support. Pediatr Crit Care Med. 2007;8(2):180Y182.
21. Tecklenburg FW, Thomas NJ, Webb SA, et al. Pediatric ECMO for severe quinidine cardiotoxicity. Pediatr Emerg Care. 1997;13(2):111Y113.