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Volumn 76, Issue 1, 2011, Pages 87-93

The paradoxical effect of bevacizumab in the therapy of malignant gliomas

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; DEXAMETHASONE; GADODIAMIDE; TEMOZOLOMIDE; VANDETANIB; VASCULOTROPIN;

EID: 78751620483     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e318204a3af     Document Type: Article
Times cited : (96)

References (52)
  • 1
    • 20044375603 scopus 로고    scopus 로고
    • Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
    • Wang Y, Fei D, Vanderlaan M, Song A. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis 2004;7:335-345.
    • (2004) Angiogenesis , vol.7 , pp. 335-345
    • Wang, Y.1    Fei, D.2    Vanderlaan, M.3    Song, A.4
  • 2
    • 33646675851 scopus 로고    scopus 로고
    • MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
    • Pope WB, Lai A, Nghiemphu P, Mischel P, Cloughesy TF. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 2006;66:1258-1260.
    • (2006) Neurology , vol.66 , pp. 1258-1260
    • Pope, W.B.1    Lai, A.2    Nghiemphu, P.3    Mischel, P.4    Cloughesy, T.F.5
  • 3
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 4
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-2550.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 5
    • 51449122032 scopus 로고    scopus 로고
    • Bevacizumab and irinotecan therapy in glioblastoma multiforme: A series of 13 cases
    • Ali SA, McHayleh WM, Ahmad A, et al. Bevacizumab and irinotecan therapy in glioblastoma multiforme: a series of 13 cases. J Neurosurg 2008;109:268-272.
    • (2008) J. Neurosurg. , vol.109 , pp. 268-272
    • Ali, S.A.1    McHayleh, W.M.2    Ahmad, A.3
  • 6
    • 43049124382 scopus 로고    scopus 로고
    • Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors
    • Bokstein F, Shpigel S, Blumenthal DT. Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors. Cancer 2008;112:2267-2273.
    • (2008) Cancer , vol.112 , pp. 2267-2273
    • Bokstein, F.1    Shpigel, S.2    Blumenthal, D.T.3
  • 7
    • 46949103217 scopus 로고    scopus 로고
    • Irinotecan and bevacizumab in progressive primary brain tumors, an evaluation of efficacy and safety
    • Kang TY, Jin T, Elinzano H, Peereboom D. Irinotecan and bevacizumab in progressive primary brain tumors, an evaluation of efficacy and safety. J Neurooncol 2008;89:113-118.
    • (2008) J. Neurooncol , vol.89 , pp. 113-118
    • Kang, T.Y.1    Jin, T.2    Elinzano, H.3    Peereboom, D.4
  • 8
    • 60649116273 scopus 로고    scopus 로고
    • Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: Impact on local control and patient survival
    • Narayana A, Kelly P, Golfinos J, et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. J Neurosurg 2009;110:173-180.
    • (2009) J. Neurosurg. , vol.110 , pp. 173-180
    • Narayana, A.1    Kelly, P.2    Golfinos, J.3
  • 9
    • 60749106240 scopus 로고    scopus 로고
    • Phase II study of bevacizumab and etoposide in patients with recurrent malignant glioma
    • Rich JN, Desjardins A, Sathornsumetee S, et al. Phase II study of bevacizumab and etoposide in patients with recurrent malignant glioma. J Clin Oncol (Meeting Abstracts) 2008;26:2022.
    • (2008) J. Clin. Oncol. (Meeting Abstracts) , vol.26 , pp. 2022
    • Rich, J.N.1    Desjardins, A.2    Sathornsumetee, S.3
  • 10
    • 77954129869 scopus 로고    scopus 로고
    • Treatment with bevacizumab plus carboplatin for recurrent malignant glioma
    • Thompson EM, Dosa E, Kreamer DF, Neuwelt E. Treatment with bevacizumab plus carboplatin for recurrent malignant glioma. Neurosurgery 2010;67:87-93.
    • (2010) Neurosurgery , vol.67 , pp. 87-93
    • Thompson, E.M.1    Dosa, E.2    Kreamer, D.F.3    Neuwelt, E.4
  • 11
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007;13:1253-1259.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 12
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007;25:4722-4729.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 13
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27:4733-4740.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 14
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of singleagent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K, et al. Phase II trial of singleagent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009;27:740-745.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 15
    • 44849138808 scopus 로고    scopus 로고
    • Progressionfree survival: An important end point in evaluating therapy for recurrent high-grade gliomas
    • Lamborn KR, Yung WK, Chang SM, et al. Progressionfree survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro-Oncol 2008;10:162-170.
    • (2008) Neuro-Oncol. , vol.10 , pp. 162-170
    • Lamborn, K.R.1    Yung, W.K.2    Chang, S.M.3
  • 16
    • 0032767387 scopus 로고    scopus 로고
    • Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials
    • Wong ET, Hess KR, Gleason MJ, et al. Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 1999;17:2572-2578.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2572-2578
    • Wong, E.T.1    Hess, K.R.2    Gleason, M.J.3
  • 18
    • 79953766034 scopus 로고    scopus 로고
    • Bevacizumab (BV) in combination to temozolomide (TMZ) and radiation therapy (RT) followed by BV, TMZ and irinotecan (CPT-11) for newly diagnosed glioblastoma multiforme (GBM): A phase 2 trial
    • Presented at the, October 22-24, New Orleans, LA
    • Desjardins A, Reardon DA, Peters K, et al. Bevacizumab (BV) in combination to temozolomide (TMZ) and radiation therapy (RT) followed by BV, TMZ and irinotecan (CPT-11) for newly diagnosed glioblastoma multiforme (GBM): a phase 2 trial. Presented at the annual meeting of the Society for Neuro-Oncology; October 22-24, 2009; New Orleans, LA.
    • (2009) Annual Meeting of the Society for Neuro-oncology
    • Desjardins, A.1    Reardon, D.A.2    Peters, K.3
  • 19
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
    • Lai A, Filka E, McGibbon B, et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 2008;71:1372-1380.
    • (2008) Int. J. Radiat. Oncol. Biol. Phys. , vol.71 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 20
    • 85031240670 scopus 로고    scopus 로고
    • RTOG. Phase III double-blind placebo-controlled trial of conventional concurrent chemoradiation and adjuvant temozolomide plus bevacizumab versus conventional concurrent chemoradiation and adjuvant temozolomide in patients with newly diagnosed glioblastoma. Available at:, Accessed April 19, 2010
    • RTOG. Phase III double-blind placebo-controlled trial of conventional concurrent chemoradiation and adjuvant temozolomide plus bevacizumab versus conventional concurrent chemoradiation and adjuvant temozolomide in patients with newly diagnosed glioblastoma. Available at: www.rtog.org/members/protocols/ 0825/0825.pdf. Accessed April 19, 2010.
  • 21
    • 75749119698 scopus 로고    scopus 로고
    • Addition of bevacizumab to the multi-modality standard of care in patients with newly diagnosed glioblastoma: A phase III trial
    • Chinot O, de la Motte Rouge T, Moore N, Zeaiter A. Addition of bevacizumab to the multi-modality standard of care in patients with newly diagnosed glioblastoma: a phase III trial. Eur J Cancer Suppl 2009;7:497.
    • (2009) Eur. J. Cancer Suppl. , vol.7 , pp. 497
    • Chinot, O.1    De La Motte Rouge, T.2    Moore, N.3    Zeaiter, A.4
  • 22
    • 0035816177 scopus 로고    scopus 로고
    • Delivery of molecular medicine to solid tumors: Lessons from in vivo imaging of gene expression and function
    • Jain RK. Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. J Control Release 2001;74:7-25.
    • (2001) J. Control Release , vol.74 , pp. 7-25
    • Jain, R.K.1
  • 24
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008;8:579-591.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 25
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005;69(suppl 3): 11):11-16.
    • (2005) Oncology , vol.69 , Issue.3 SUPPL. , pp. 11-16
    • Ferrara, N.1
  • 26
    • 34447121919 scopus 로고    scopus 로고
    • Bevacizumabinduced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
    • Dickson PV, Hamner JB, Sims TL, et al. Bevacizumabinduced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res 2007;13:3942-3950.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3942-3950
    • Dickson, P.V.1    Hamner, J.B.2    Sims, T.L.3
  • 28
    • 4644304024 scopus 로고    scopus 로고
    • Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option
    • Leenders WP, Kusters B, Verrijp K, et al. Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clin Cancer Res 2004;10:6222-6230.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6222-6230
    • Leenders, W.P.1    Kusters, B.2    Verrijp, K.3
  • 29
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to antiangiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to antiangiogenic therapy. Nat Rev Cancer 2008;8:592-603.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 30
    • 72549116837 scopus 로고    scopus 로고
    • The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: Potential implications for the current approach to chemoradiation
    • Portnow J, Badie B, Chen M, Liu A, Blanchard S, Synold TW. The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation. Clin Cancer Res 2009;15:7092-7098.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7092-7098
    • Portnow, J.1    Badie, B.2    Chen, M.3    Liu, A.4    Blanchard, S.5    Synold, T.W.6
  • 31
    • 77952309402 scopus 로고    scopus 로고
    • Tumor invasion after treatment of glioblastoma with bevacizumab: Radiographic and pathologic correlation in humans and mice
    • de Groot JF, Fuller G, Kumar AJ, et al. Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice. Neuro-Oncol 2010;12:233-242.
    • (2010) Neuro-Oncol. , vol.12 , pp. 233-242
    • De Groot, J.F.1    Fuller, G.2    Kumar, A.J.3
  • 32
    • 58149456505 scopus 로고    scopus 로고
    • Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan
    • Zuniga RM, Torcuator R, Jain R, et al. Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan. J Neurooncol 2009;91:329-336.
    • (2009) J. Neurooncol , vol.91 , pp. 329-336
    • Zuniga, R.M.1    Torcuator, R.2    Jain, R.3
  • 33
    • 70350142397 scopus 로고    scopus 로고
    • Patterns of relapse and prognosis after bevacizumab failure in recurrent glioblastoma
    • Iwamoto FM, Abrey LE, Beal K, et al. Patterns of relapse and prognosis after bevacizumab failure in recurrent glioblastoma. Neurology 2009;73:1200-1206.
    • (2009) Neurology , vol.73 , pp. 1200-1206
    • Iwamoto, F.M.1    Abrey, L.E.2    Beal, K.3
  • 34
    • 77951625266 scopus 로고    scopus 로고
    • Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group
    • Wen PY, Macdonald DR, Reardon DA, et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 2010;28:1963-1972.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1963-1972
    • Wen, P.Y.1    Macdonald, D.R.2    Reardon, D.A.3
  • 35
    • 0025804070 scopus 로고
    • Correlation between magnetic resonance imaging and histopathology of intracranial glioma
    • Iwama T, Yamada H, Sakai N, et al. Correlation between magnetic resonance imaging and histopathology of intracranial glioma. Neurol Res 1991;13:48-54.
    • (1991) Neurol. Res. , vol.13 , pp. 48-54
    • Iwama, T.1    Yamada, H.2    Sakai, N.3
  • 36
    • 44649095050 scopus 로고    scopus 로고
    • Time course of imaging changes of GBM during extended bevacizumab treatment
    • Ananthnarayan S, Bahng J, Roring J, et al. Time course of imaging changes of GBM during extended bevacizumab treatment. J Neurooncol 2008;88:339-347.
    • (2008) J. Neurooncol , vol.88 , pp. 339-347
    • Ananthnarayan, S.1    Bahng, J.2    Roring, J.3
  • 37
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
    • Norden AD, Young GS, Setayesh K, et al. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 2008;70:779-787.
    • (2008) Neurology , vol.70 , pp. 779-787
    • Norden, A.D.1    Young, G.S.2    Setayesh, K.3
  • 38
    • 64149110218 scopus 로고    scopus 로고
    • Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model
    • Varallyay CG, Muldoon LL, Gahramanov S, et al. Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model. J Cereb Blood Flow Metab 2009;29:853-860.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 853-860
    • Varallyay, C.G.1    Muldoon, L.L.2    Gahramanov, S.3
  • 39
    • 85031266388 scopus 로고    scopus 로고
    • NCBI, Available at:, Accessed April 19, 2010
    • NCBI. Gadodiamide: Compound Summary (CID 24838310). Available at: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=197004&viewopt= PubChem. Accessed April 19, 2010.
    • Gadodiamide: Compound Summary (CID 24838310)
  • 40
    • 85031259924 scopus 로고    scopus 로고
    • NCBI, Available at:, Accessed June 25, 2010
    • NCBI. Irinotecan: compound summary (CID 104842). Available at: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=104842&loc=ec-rcs. Accessed June 25, 2010.
    • Irinotecan: Compound Summary (CID 104842)
  • 41
    • 73949137249 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review
    • Weinstein JS, Varallyay CG, Dosa E, et al. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab 2010;30:15-35.
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 15-35
    • Weinstein, J.S.1    Varallyay, C.G.2    Dosa, E.3
  • 42
    • 77956666382 scopus 로고    scopus 로고
    • Updated safety and survival in patients with relapsed glioblastoma treated with bevacizumab in the BRAIN study
    • Cloughesy T, Vredenburgh JJ, Day BM, et al. Updated safety and survival in patients with relapsed glioblastoma treated with bevacizumab in the BRAIN study. Am Soc Clin Oncol 2010;28:15s.
    • (2010) Am. Soc. Clin. Oncol. , vol.28
    • Cloughesy, T.1    Vredenburgh, J.J.2    Day, B.M.3
  • 44
    • 42649106522 scopus 로고    scopus 로고
    • Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
    • Brandsma D, Stalpers L, Taal W, Sminia P, van den Bent MJ. Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 2008;9:453-461.
    • (2008) Lancet Oncol. , vol.9 , pp. 453-461
    • Brandsma, D.1    Stalpers, L.2    Taal, W.3    Sminia, P.4    Van Den Bent, M.J.5
  • 45
    • 43749094544 scopus 로고    scopus 로고
    • MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • Brandes AA, Franceschi E, Tosoni A, et al. MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol 2008;26:2192-2197.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 46
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 47
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-996.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 48
    • 78751629807 scopus 로고    scopus 로고
    • Potential for differentiation of pseudoprogression from true tumor progression with dynamic susceptibility-weighted contrast-enhanced magnetic resonance imaging using ferumoxytol vs. gadoteridol: A pilot study
    • April 13
    • Gahramanov S, Raslan AM, Muldoon LL, et al. Potential for differentiation of pseudoprogression from true tumor progression with dynamic susceptibility-weighted contrast-enhanced magnetic resonance imaging using ferumoxytol vs. gadoteridol: a pilot study. Int J Radiat Oncol Biol Phys Epub 2010 April 13.
    • (2010) Int. J. Radiat. Oncol. Biol. Phys. Epub
    • Gahramanov, S.1    Raslan, A.M.2    Muldoon, L.L.3
  • 49
    • 23044502688 scopus 로고    scopus 로고
    • Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy
    • Cao Y, Tsien CI, Shen Z, et al. Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy. J Clin Oncol 2005;23:4127-4136.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4127-4136
    • Cao, Y.1    Tsien, C.I.2    Shen, Z.3
  • 50
    • 56749136293 scopus 로고    scopus 로고
    • What is the place of bevacizumab and irinotecan in the treatment of glioblastoma and other malignant gliomas?
    • Omuro AM, Delattre JY. What is the place of bevacizumab and irinotecan in the treatment of glioblastoma and other malignant gliomas? Curr Opin Neurol 2008;21:717-719.
    • (2008) Curr. Opin. Neurol. , vol.21 , pp. 717-719
    • Omuro, A.M.1    Delattre, J.Y.2
  • 51
    • 78751605926 scopus 로고    scopus 로고
    • European Medicines Agency, London: European Medicines Agency
    • European Medicines Agency. Refusal Assessment Report for Avastin. London: European Medicines Agency; 2010.
    • (2010) Refusal Assessment Report for Avastin
  • 52
    • 44449133653 scopus 로고    scopus 로고
    • Gliomas: Predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrastenhanced perfusion MR imaging
    • Law M, Young RJ, Babb JS, et al. Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrastenhanced perfusion MR imaging. Radiology 2008;247:490-498.
    • (2008) Radiology , vol.247 , pp. 490-498
    • Law, M.1    Young, R.J.2    Babb, J.S.3


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