-
2
-
-
41749114071
-
GIP-based therapeutics for diabetes and obesity
-
Irwin N., Flatt P.R., Gault V.A. GIP-based therapeutics for diabetes and obesity. Curr. Chem. Biol. 2008, 2:61-68.
-
(2008)
Curr. Chem. Biol.
, vol.2
, pp. 61-68
-
-
Irwin, N.1
Flatt, P.R.2
Gault, V.A.3
-
3
-
-
34248223285
-
Biology of incretins: GLP-1 and GIP
-
Baggio L.L., Drucker D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132:2131-2137.
-
(2007)
Gastroenterology
, vol.132
, pp. 2131-2137
-
-
Baggio, L.L.1
Drucker, D.J.2
-
4
-
-
0141785429
-
Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
-
Ehses J.A., Casilla V.R., Doty T., et al. Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase. Endocrinology 2003, 144:4433-4445.
-
(2003)
Endocrinology
, vol.144
, pp. 4433-4445
-
-
Ehses, J.A.1
Casilla, V.R.2
Doty, T.3
-
5
-
-
0036687655
-
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells
-
Trümper A., Trümper K., Hörsch D. Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells. J. Endocrinol. 2002, 174:233-246.
-
(2002)
J. Endocrinol.
, vol.174
, pp. 233-246
-
-
Trümper, A.1
Trümper, K.2
Hörsch, D.3
-
6
-
-
77955611520
-
Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?
-
Irwin N., Gault V.A., Flatt P.R. Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?. Expert Opin. Investig. Drugs 2010, 19:1039-1048.
-
(2010)
Expert Opin. Investig. Drugs
, vol.19
, pp. 1039-1048
-
-
Irwin, N.1
Gault, V.A.2
Flatt, P.R.3
-
7
-
-
0029118049
-
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide-1 in vitro and in vivo by dipeptidyl peptidase IV
-
Kieffer T.J., McIntosh C.H., Pederson R.A. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide-1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995, 136:3585-3596.
-
(1995)
Endocrinology
, vol.136
, pp. 3585-3596
-
-
Kieffer, T.J.1
McIntosh, C.H.2
Pederson, R.A.3
-
8
-
-
1442350411
-
Secretion, degradation, and elimination of glucagon-like peptide-1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
-
Meier J.J., Nauck M.A., Kranz D., et al. Secretion, degradation, and elimination of glucagon-like peptide-1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes 2004, 53:654-662.
-
(2004)
Diabetes
, vol.53
, pp. 654-662
-
-
Meier, J.J.1
Nauck, M.A.2
Kranz, D.3
-
9
-
-
12244281855
-
Circulation and degradation of GIP and GLP-1
-
Deacon C.F. Circulation and degradation of GIP and GLP-1. Horm. Metab. Res. 2004, 36:761-765.
-
(2004)
Horm. Metab. Res.
, vol.36
, pp. 761-765
-
-
Deacon, C.F.1
-
10
-
-
1442321740
-
Evidence that the major metabolic degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
-
Gault V.A., Parker J.C., Harriott P., et al. Evidence that the major metabolic degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J. Endocrinol. 2002, 175:525-533.
-
(2002)
J. Endocrinol.
, vol.175
, pp. 525-533
-
-
Gault, V.A.1
Parker, J.C.2
Harriott, P.3
-
11
-
-
33748453750
-
GIP(3-42) does not antagonise insulinotropic effects of GIP at physiological concentrations
-
Deacon C.F., Plamboeck A., Rosenkilde M.M., et al. GIP(3-42) does not antagonise insulinotropic effects of GIP at physiological concentrations. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E468-E475.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
-
-
Deacon, C.F.1
Plamboeck, A.2
Rosenkilde, M.M.3
-
12
-
-
33751055819
-
Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice
-
Parker J.C., Lavery K.S., Irwin N., et al. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. J. Endocrinol. 2006, 191:93-100.
-
(2006)
J. Endocrinol.
, vol.191
, pp. 93-100
-
-
Parker, J.C.1
Lavery, K.S.2
Irwin, N.3
-
13
-
-
0242432370
-
Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide
-
Gault V.A., Harriott P., Flatt P.R., O'Harte F.P. Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. Biosci. Rep. 2002, 22:523-528.
-
(2002)
Biosci. Rep.
, vol.22
, pp. 523-528
-
-
Gault, V.A.1
Harriott, P.2
Flatt, P.R.3
O'Harte, F.P.4
-
14
-
-
0030747857
-
GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro
-
Gelling R.W., Coy D.H., Pederson R.A., et al. GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro. Regul. Pept. 1997, 69:151-154.
-
(1997)
Regul. Pept.
, vol.69
, pp. 151-154
-
-
Gelling, R.W.1
Coy, D.H.2
Pederson, R.A.3
-
15
-
-
0033037273
-
Effect of GIP and GLP-1 antagonists on insulin release in the rat
-
Tseng C.C., Zhang X.Y., Wolfe M.M. Effect of GIP and GLP-1 antagonists on insulin release in the rat. Am. J. Physiol. 1996, 276:E1049-E1054.
-
(1996)
Am. J. Physiol.
, vol.276
-
-
Tseng, C.C.1
Zhang, X.Y.2
Wolfe, M.M.3
-
16
-
-
0036289106
-
Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide
-
Gault V.A., O'Harte F.P., Harriott P., Flatt P.R. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem. Biophys. Res. Commun. 2002, 290:1420-1426.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.290
, pp. 1420-1426
-
-
Gault, V.A.1
O'Harte, F.P.2
Harriott, P.3
Flatt, P.R.4
-
17
-
-
23644434110
-
3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities if islet structure in obesity-related diabetes
-
3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities if islet structure in obesity-related diabetes. Diabetes 2005, 54:2436-2446.
-
(2005)
Diabetes
, vol.54
, pp. 2436-2446
-
-
Gault, V.A.1
Irwin, N.2
Green, B.D.3
-
18
-
-
34447127048
-
Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets
-
Gault V.A., McClean P.L., Cassidy R.S., et al. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia 2007, 50:1752-1762.
-
(2007)
Diabetologia
, vol.50
, pp. 1752-1762
-
-
Gault, V.A.1
McClean, P.L.2
Cassidy, R.S.3
-
19
-
-
0036068322
-
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
-
Miyawaki K., Yamada Y., Ban N., et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat. Med. 2002, 8:738-742.
-
(2002)
Nat. Med.
, vol.8
, pp. 738-742
-
-
Miyawaki, K.1
Yamada, Y.2
Ban, N.3
-
21
-
-
34249932868
-
The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy
-
Alana I., Malthouse J.P., O'Harte F.P., Hewage C.M. The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy. Proteins 2007, 68:92-99.
-
(2007)
Proteins
, vol.68
, pp. 92-99
-
-
Alana, I.1
Malthouse, J.P.2
O'Harte, F.P.3
Hewage, C.M.4
-
22
-
-
33745194595
-
NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water
-
Alana I., Parker J.C., Gault V.A., et al. NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water. J. Biol. Chem. 2006, 281:16370-16376.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16370-16376
-
-
Alana, I.1
Parker, J.C.2
Gault, V.A.3
-
23
-
-
34248328787
-
Understanding interactions of gastric inhibitory polypeptide (GIP) with its G-protein coupled receptor through NMR and molecular modelling
-
Malde A.K., Srivastava S.S., Coutinho E.C. Understanding interactions of gastric inhibitory polypeptide (GIP) with its G-protein coupled receptor through NMR and molecular modelling. J. Pept. Sci. 2007, 13:287-300.
-
(2007)
J. Pept. Sci.
, vol.13
, pp. 287-300
-
-
Malde, A.K.1
Srivastava, S.S.2
Coutinho, E.C.3
-
24
-
-
77957324131
-
Mapping interactions of gastric inhibitory polypeptide with GIPR N-terminus using NMR and molecular dynamics simulations
-
Tikhele S.H., Pissurlenkar R.R., Srivastava S.S., et al. Mapping interactions of gastric inhibitory polypeptide with GIPR N-terminus using NMR and molecular dynamics simulations. J. Pept. Sci. 2010, 16:383-391.
-
(2010)
J. Pept. Sci.
, vol.16
, pp. 383-391
-
-
Tikhele, S.H.1
Pissurlenkar, R.R.2
Srivastava, S.S.3
-
25
-
-
0029742094
-
Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion
-
McClenaghan N.H., Barnett C.R., Ah-Sing E., et al. Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. Diabetes 1996, 45:1132-1140.
-
(1996)
Diabetes
, vol.45
, pp. 1132-1140
-
-
McClenaghan, N.H.1
Barnett, C.R.2
Ah-Sing, E.3
-
26
-
-
0019471997
-
Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice
-
Flatt P.R., Bailey C.J. Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 1981, 20:573-577.
-
(1981)
Diabetologia
, vol.20
, pp. 573-577
-
-
Flatt, P.R.1
Bailey, C.J.2
-
27
-
-
0020086017
-
Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice
-
Bailey C.J., Flatt P.R., Atkins T.W. Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice. Int. J. Obes. 1982, 6:11-21.
-
(1982)
Int. J. Obes.
, vol.6
, pp. 11-21
-
-
Bailey, C.J.1
Flatt, P.R.2
Atkins, T.W.3
-
28
-
-
0015038855
-
Determination of glucose by an automatic analyser
-
Stevens J.F. Determination of glucose by an automatic analyser. Clin. Chem. Acta 1971, 32:199-201.
-
(1971)
Clin. Chem. Acta
, vol.32
, pp. 199-201
-
-
Stevens, J.F.1
-
29
-
-
0027136670
-
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
-
Usdin T.B., Mezey E., Button D.C., et al. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 1993, 133:2861-2870.
-
(1993)
Endocrinology
, vol.133
, pp. 2861-2870
-
-
Usdin, T.B.1
Mezey, E.2
Button, D.C.3
-
30
-
-
69349096792
-
Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties
-
Kerr B.D., Irwin N., O'Harte F.P., et al. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochem. Pharmacol. 2009, 78:1008-1016.
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 1008-1016
-
-
Kerr, B.D.1
Irwin, N.2
O'Harte, F.P.3
-
31
-
-
0021744036
-
A novel form of gastric inhibitory polypeptide (GIP) isolated from bovine intestine using a radioreceptor assay. Fragmentation with staphylococcal protease results in GIP1-3 and GIP4-42, fragmentation with enterokinase in GIP1-16 and GIP17-42
-
Carlquist M., Maletti M., Jornvall H., Mutt V. A novel form of gastric inhibitory polypeptide (GIP) isolated from bovine intestine using a radioreceptor assay. Fragmentation with staphylococcal protease results in GIP1-3 and GIP4-42, fragmentation with enterokinase in GIP1-16 and GIP17-42. Eur. J. Biochem. 1984, 145:573-577.
-
(1984)
Eur. J. Biochem.
, vol.145
, pp. 573-577
-
-
Carlquist, M.1
Maletti, M.2
Jornvall, H.3
Mutt, V.4
-
32
-
-
0027303260
-
Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a novel factor, peptide 3910
-
Agerberth B., Boman A., Andersson M., et al. Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a novel factor, peptide 3910. Eur. J. Biochem. 1993, 216:623-629.
-
(1993)
Eur. J. Biochem.
, vol.216
, pp. 623-629
-
-
Agerberth, B.1
Boman, A.2
Andersson, M.3
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