Antioxidant supplementation and endurance training: Win or loss?

European Journal of Sport Science

Volumn 11, Issue 1, 2011, Pages 27-32

  Gross, Micah ^a   Baum, Oliver ^a   Hoppeler, Hans ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Endurance training; Free radical; Oxidative stress; Vitamin

Indexed keywords

EID: 78751607022     PISSN: 17461391     EISSN: 15367290     Source Type: Journal    
DOI: 10.1080/17461391003699088     Document Type: Article

References (56)

1. Baum, O., Da Silva-Azevedo, L., Willerding, G., Wockel, A., Planitzer, G., Gossrau, R., et al. (2004). Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration. American Journal of Physiology: Heart and Circulatory Physiology, 287, H2300-H2308.
2. Beaton, L. J., Allan, D. A., Tarnopolsky, M. A., Tiidus, P. M., & Phillips, S. M. (2002). Contraction-induced muscle damage is unaffected by vitamin e supplementation. Medicine and Science in Sports and Exercise, 34, 798-805.
3. Boveris, A., & Cadenas, E. (2000). Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life, 50, 245-250.
4. Braun, H., Koehler, K., Geyer, H., Kleiner, J., Mester, J., & Schanzer, W. (2009). Dietary supplement use among elite young German athletes. International Journal of Sport Nutrition and Exercise Metabolism, 19, 97-109.
5. Chan, K. M., & Decker, E. A. (1994). Endogenous skeletal muscle antioxidants. Critical Reviews in Food Science and Nutrition, 34, 403-426.
6. Chance, B., Sies, H., & Boveris, A. (1979). Hydroperoxide metabolism in mammalian organs. Physiological Review, 59, 527-605.
7. Childs, A., Jacobs, C., Kaminski, T., Halliwell, B., & Leeuwenburgh, C. (2001). Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radical Biology and Medicine, 31, 745-753.
8. Clifford, P. S., & Hellsten, Y. (2004). Vasodilatory mechanisms in contracting skeletal muscle. Journal of Applied Physiology, 97, 393-403.
9. Close, G. L., Ashton, T., Cable, T., Doran, D., Holloway, C., McArdle, F., et al. (2006). Ascorbic acid supplementation does not attenuate post-exercise muscle soreness following muscledamaging exercise but may delay the recovery process. British Journal of Nutrition, 95, 976-981.
10. Connolly, D. A., Lauzon, C., Agnew, J., Dunn, M., & Reed, B. (2006). The effects of vitamin C supplementation on symptoms of delayed onset muscle soreness. Journal of Sports Medicine and Physical Fitness, 46, 462-467.
11. Davies, K. J., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982). Free radicals and tissue damage produced by exercise. Biochemical and Biophysical Research Communications, 107, 1198-1205.
12. Froiland, K., Koszewski, W., Hingst, J., & Kopecky, L. (2004). Nutritional supplement use among college athletes and their sources of information. International Journal of Sport Nutrition and Exercise Metabolism, 14, 104-120.
13. Gibala, M. (2009). Molecular responses to high-intensity interval exercise. Applied Physiology, Nutrition and Metabolism, 34, 428-432.
14. Gomez-Cabrera, M. C., Borras, C., Pallardo, F. V., Sastre, J., Ji, L. L., & Vina, J. (2005). Decreasing xanthine oxidasemediated oxidative stress prevents useful cellular adaptations to exercise in rats. Journal of Physiology, 567, 113-120.
15. Gomez-Cabrera, M. C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., et al. (2008a). Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. American Journal of Clinical Nutrition, 87, 142-149.
16. Gomez-Cabrera, M. C., Domenech, E., & Vina, J. (2008b). Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radical Biology and Medicine, 44, 126-131.
17. Hellsten, Y., Frandsen, U., Orthenblad, N., Sjodin, B., & Richter, E. A. (1997). Xanthine oxidase in human skeletal muscle following eccentric exercise: A role in inflammation. Journal of Physiology, 498, 239-248.
18. Hudlicka, O., Brown, M. D., & Silgram, H. (2000). Inhibition of capillary growth in chronically stimulated rat muscles by N(v)-nitro-L-arginine, nitric oxide synthase inhibitor. Microvascular Research, 59, 45-51.
19. Jackson, M. J. (2009). Redox regulation of adaptive responses in skeletal muscle to contractile activity. Free Radical Biology and Medicine, 47, 1267-1275.
20. Ji, L. L. (2007). Antioxidant signaling in skeletal muscle: A brief review. Experimental Gerontology, 42, 582-593.
21. Ji, L. L. (2008). Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radical Biology and Medicine, 44, 142-152.
22. Ji, L. L., Gomez-Cabrera, M. C., & Vina, J. (2006). Exercise and hormesis: Activation of cellular antioxidant signaling pathway. Annals of the New York Academy of Sciences, 1067, 425-435.
23. Kanter, M. (1998). Free radicals, exercise and antioxidant supplementation. Proceedings of the Nutrition Society, 57, 9-13.
24. Kayar, S. R., Hoppeler, H., Armstrong, R. B., Laughlin, M. H., Lindstedt, S. L., Jones, J. H., et al. (1992). Estimating transit time for capillary blood in selected muscles of exercising animals. Pflugers Archive, 421, 578-584.
25. Kellogg, E. W., III, & Fridovich, I. (1975). Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system. Journal of Biological Chemistry, 250, 8812-8817.
26. Knez, W. L., Jenkins, D. G., & Coombes, J. S. (2007). Oxidative stress in half and full ironman triathletes. Medicine and Science in Sports and Exercise, 39, 283-288.
27. Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994). Nitric oxide in skeletal muscle. Nature, 372, 546-548.
28. Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992). Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chemical Research in Toxicology, 5, 834-842.
29. Koren, A., Sauber, C., Sentjurc, M., & Schara, M. (1983). Free radicals in tetanic activity of isolated skeletal muscle. Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology, 74, 633-635.
30. Kreider, R. B., Almada, A. L., Antonio, J., Broeder, C., Earnest, C., Greenwood, M., et al. (2004). ISSN exercise and sport nutrition review: Research and recommendations. Sports Nutrition Review Journal, 1, 1-44.
31. Krumbach, C. J., Ellis, D. R., & Driskell, J. A. (1999). A report of vitamin and mineral supplement use among university athletes in a division I institution. International Journal of Sport Nutrition, 9, 416-425.
32. Lai, C. S., & Piette, L. H. (1977). Hydroxyl radical production involved in lipid peroxidation of rat liver microsomes. Biochemical and Biophysical Research Communications, 78, 51-59.
33. Margaritis, I., & Rousseau, A. S. (2008). Does physical exercise modify antioxidant requirements? Nutrition Research Reviews, 21, 3-12.
34. McGinley, C., Shafat, A., & Donnelly, A. E. (2009). Does antioxidant vitamin supplementation protect against muscle damage? Sports Medicine, 39, 1011-1032.
35. Medved, I., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S., et al. (2004). N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurancetrained individuals. Journal of Applied Physiology, 97, 1477-1485.
36. Padilla, J., & Mickleborough, T. D. (2007). Does antioxidant supplementation prevent favorable adaptations to exercise training? Medicine and Science in Sports and Exercise, 39, 1887; author reply 1888.
37. Pialoux, V., Mounier, R., Ponsot, E., Rock, E., Mazur, A., Dufour, S., et al. (2006). Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance. European Journal of Clinical Nutrition, 60, 1345-1354.
38. Pialoux, V., Mounier, R., Rock, E., Mazur, A., Schmitt, L., Richalet, J. P., et al. (2009a). Effects of the "live high-train low" method on prooxidant/antioxidant balance on elite athletes. European Journal of Clinical Nutrition, 63, 756-762.
39. Pialoux, V., Mounier, R., Rock, E., Mazur, A., Schmitt, L., Richalet, J. P., et al. (2009b). Effects of acute hypoxic exposure on prooxidant/antioxidant balance in elite endurance athletes. International Journal of Sports Medicine, 30, 87-93.
40. Powers, S. K., & Jackson, M. J. (2008). Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production. Physiological Reviews, 88, 1243-1276.
41. Pryor, W. A., & Squadrito, G. L. (1995). The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. American Journal of Physiology: Lung Cellular and Molecular Physiology, 268, L699-L722.
42. Reid, M. B. (2008). Free radicals and muscle fatigue: Of ros, canaries, and the ioc. Free Radical Biology and Medicine, 44, 169-179.
43. Ristow, M., Zarse, K., Oberbach, A., Kloting, N., Birringer, M., Kiehntopf, M., et al. (2009). Antioxidants prevent healthpromoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences USA, 106, 8665-8670.
44. Rodriguez, N. R., Di Marco, N. M., & Langley, S. (2009). American College of Sports Medicine position stand: Nutrition and athletic performance. Medicine and Science in Sports and Exercise, 41, 709-731.
45. Sastre, J., Asensi, M., Gasco, E., Pallardo, F. V., Ferrero, J. A., Furukawa, T., et al. (1992). Exhaustive physical exercise causes oxidation of glutathione status in blood: Prevention by antioxidant administration. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 263, R992-R995.
46. Sies, H., & Stahl, W. (1995). Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. American Journal of Clinical Nutrition, 62, 1315S-1321S.
47. Simon-Schnass, I., & Pabst, H. (1988). Influence of vitamin E on physical performance. International Journal for Vitamin and Nutrition Research, 58, 49-54.
48. Sobal, J., & Marquart, L. F. (1994). Vitamin/mineral supplement use among athletes: A review of the literature. International Journal of Sports Nutrition, 4, 320-334.
49. St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002). Topology of superoxide production from different sites in the mitochondrial electron transport chain. Journal of Biological Chemistry, 277, 44784-44790.
50. Stamler, J. S., Sun, Q. A., & Hess, D. T. (2008). A SNO storm in skeletal muscle. Cell, 133, 33-35.
51. Symons, M. C. (1988). Formation of radicals by mechanical processes. Free Radical Research Communications, 5, 131-139.
52. Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., & Moreira, P. A. (2009). Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Medicine and Science in Sports and Exercise, 41, 1752-1760.
53. Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004). Role of oxygen radicals in DNA damage and cancer incidence. Molecular and Cellular Biochemistry, 266, 37-56.
54. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology, 39, 44-84.
55. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions, 160, 1-40.
56. Wray, D. W., Uberoi, A., Lawrenson, L., Bailey, D. M., & Richardson, R. S. (2009). Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: A radically different outcome. Clinical Science (London), 116, 433-441.