In vivo toxicity and immunogenicity of wheat germ agglutinin conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal delivery to the brain

Toxicology and Applied Pharmacology

Volumn 251, Issue 1, 2011, Pages 79-84

  Liu, Qingfeng ^a   Shao, Xiayan ^a   Chen, Jie ^a   Shen, Yehong ^a   Feng, Chengcheng ^a   Gao, Xiaoling ^a   Zhao, Yue ^a   Li, Jingwei ^a   Zhang, Qizhi ^a   Jiang, Xinguo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Brain; Immunogenicity; Intranasal; Poly(ethylene glycol) poly(lactic acid) nanoparticle; Toxicity; WGA

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMINO ACID RECEPTOR AFFECTING AGENT; BRAIN PROTEIN; DRUG CARRIER; GLUTAMIC ACID; GLUTATHIONE; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MACROGOL; NANOPARTICLE; POLYLACTIC ACID; TUMOR NECROSIS FACTOR ALPHA; WHEAT GERM AGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OLFACTORY BULB; RAT;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ADMINISTRATION, INTRANASAL; AMINO ACIDS; ANIMALS; ANTIBODIES; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE; INTERLEUKIN-8; L-LACTATE DEHYDROGENASE; LACTIC ACID; MALE; MICE; MICE, INBRED BALB C; NANOPARTICLES; OLFACTORY BULB; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WHEAT GERM AGGLUTININS;

MUS; RATTUS; TRITICUM AESTIVUM;

EID: 78751605015     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.12.003     Document Type: Article

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