Heat stability of agaritine in water extracts from Agaricus blazei and other edible fungi, and removal of agaritine by ethanol fractionation

Food Chemistry

Volumn 126, Issue 3, 2011, Pages 1172-1177

  Koge, Takashi ^a   Komatsu, Wataru ^a   Sorimachi, Kenji ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Agaricus; Agaritine; Alternative medicine; Edible mushrooms; Ethanol fractionation; Hydrazine derivatives

Indexed keywords

AGARICUS; AGARITINE; ALTERNATIVE MEDICINE; EDIBLE MUSHROOM; ETHANOL FRACTIONATION;

ETHANOL; FUNGI; HEALTH RISKS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDRAZINE; MEDICINE; METHANOL;

SOLVENT EXTRACTION;

AGARICUS BLAZEI EXTRACT; AGARITINE; CARCINOGEN; METHANOL; UNCLASSIFIED DRUG;

AGARICUS BISPORUS; ARTICLE; FRACTIONATION; NONHUMAN; QUANTITATIVE ANALYSIS; THERMOSTABILITY;

AGARICUS; AGARICUS BISPORUS; AGARICUS BLAZEI; BASIDIOMYCOTA; FUNGI;

EID: 78751581639     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2010.11.153     Document Type: Article

References (36)

1. Akiyama, H., Kondo, K., Maitani, T. (2004) Research on evaluation of toxicological compounds in basidiomyceteae. Research report from the Japan's Ministry of Health, Labour and Welfare (in Japanese), pp. 1-8.
2. A.T. Borchers, J.S. Stern, R.M. Hackman, C.L. Keen, and M.E. Gershwin Mushrooms, tumors, and immunity Proceedings of the Society for Experimental Biology and Medicine 221 1999 281 293
3. Y. Chauhan, D. Nagel, M. Gross, R. Cerny, and B. Toth Isolation of N-[γ-l-(+)glutamyl]-4-carboxyphenylhydrazine in the cultivated mushroom Agaricus bisporus Journal of Agricultural Food Chemistry 33 1985 817 820
4. Y. Chauhan, D. Nagel, P. Issenberg, and B. Toth Identification of p-hydrazinobenzoic acid in the commercial mushroom Agaricus bisporus Journal of Agricultural Food Chemistry 32 1984 1067 1069
5. G. Chihara, J. Hamuro, Y.Y. Maeda, T. Shiio, T. Suga, and N. Takasuka Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: An overview Cancer Detection and Prevention Supplement 1 1987 423 443
6. M. Fisher, and L.X. Yang Anticancer effects and mechanisms of polysaccharide-K (PSK): Implications of cancer immunotherapy Anticancer Research 22 2002 1737 1754
7. D.T. Førland, E. Johnson, A.M. Tryggestad, T. Lyberg, and G. Hetland An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vivo Cytokine 49 2010 245 250
8. W.-N. Gao, D.-Q. Wei, Y. Li, H. Gao, W.-R. Xu, and A.-X. Li Agaritine and its derivatives are potential inhibitors against HIV proteases Medicinal Chemistry 3 2007 221 226
9. J. Hajšlová, L. Hájková, V. Schulzová, H. Franden, J. Gry, and H.C. Andersson Stability of agaritine-a natural toxicant of Agaricus mushrooms Food Additives and Contaminants 19 2002 1028 1033
10. C.H. Hsu, K.C. Hwang, Y.H. Chiang, and P. Chou The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B Journal of alternative and complementary medicine 14 2008 299 301
11. H. Ito, K. Shimura, H. Itoh, and M. Kawade Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanisms in tumor-bearing mice Anticancer Research 17 1997 277 284
12. P.V. Jeurink, C.L. Noguera, H.F. Savelkoul, and H.J. Wichers Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells International Immunopharmacology 8 2008 1124 1133
13. H. Kawagishi, R. Inagaki, T. Kanao, T. Mizuno, K. Shimura, and H. Ito Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies Carbohydrate Research 186 1989 267 273
14. Y. Kimura New anticancer agents: In vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants In Vivo 19 2005 37 60
15. K. Kondo, A. Watanabe, Y. Iwanaga, I. Abe, H. Tanaka, and M. Hamano-Nagaoka Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography-tandem mass spectrometry Journal of chromatography B 834 2006 55 61
16. B. Levenverg Structure and enzymatic cleavage of agaritine, a phenylhydrazine of l-glutamic acid isolated from Agaricaceae Journal of the American Chemical Society 83 1961 503 504
17. H. Maruyama, K. Yamazaki, S. Murofushi, C. Konda, and T. Ikekawa Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst Journal of Pharmacobio-Dynamics 12 1989 118 123
18. M.L. Ng, and A.T. Yap Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes) Journal of alternative and complementary medicine 8 2002 581
19. Official documents of the Japan Ministry of Health, Labour and Welfare. (2009). Regarding Agaricus products (in Japanese), Food Security Standard, 0703 (No. 1), 1-5.
20. M.M. Padilha, A.A. Avila, P.J. Sousa, L.G. Cardoso, F.F. Perazza, and J.C. Carvalho Anti-inflammatory activity of a aqueous and alkaline extracts from mushroom (Agaricus blazei Murill) Journal of medicinal food 12 2009 359 364
21. A.E. Ross, D.L. Nagel, and B. Toth Occurrence, stability and decomposition of β-N-(γ-l-glutamyl)-4-hydroxymethylhydrazine (agaritine) from the mushroom Agaricus bisporus Food and Chemical Toxicology 20 1982 903 907
22. A.E. Ross, D.L. Nagel, and B. Toth Evidence for the occurrence and formation of diazonium ions in the Agaricus bisporus mushroom and its extracts Journal of agricultural and food chemistry 30 1982 521 525
23. K. Sorimachi, K. Akimoto, Y. Ikehara, K. Inafuku, A. Okubo, and S. Yamazaki Secretion of TNF-α, IL-8, and Nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro Cell Structure and Function 26 2001 103 108
24. K. Sorimachi, K. Akimoto, and T. Koge Inhibitory effect of Agaricus blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells Bioscience, Biotechnology, and Biochemistry 72 2008 621 623
25. K. Sorimachi, Y. Ikehara, G. Maezato, A. Okubo, S. Yamazaki, and K. Akimoto Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by Western equine encephalitis (WEE) virus on VERO cells in vitro Bioscience, Biotechnology, and Biochemistry 565 2001 1645 1647
26. K. Sorimachi, and T. Koge Agaricus blazei water extracts as alternative medicines Current pharmaceutical Analysis 4 2008 39 43
27. R. Sullivan, J.E. Smith, and N.J. Rowan Medicinal mushrooms and cancer therapy: Translating a traditional practice into Western medicine Perspectives in Biology and Medicine 49 2006 159 170
28. B. Toth A review of the natural occurrence, synthetic production and use of carcinogenic hydrazines and related chemicals In Vivo 14 2000 299 319
29. B. Toth, and J. Erickson Cancer induction in mice by feeding of the uncooked cultivated mushroom of commerce Agaricus bisporus Cancer Research 46 1986 4007 4011
30. B. Toth, J. Erickson, P.M. Gannett, and K. Path Carcinogenesis by the cultivated baked Agaricus bisporus mushroom in mice Oncology Reports 4 1997 931 936
31. B. Toth, P. Gannett, W.J. Visek, and K. Path Carcinogenesis studies with the lyophilized mushroom Agaricus bisporus in mice In Vivo 12 1998 239 244
32. B. Toth, D. Nagel, K. Patil, J. Erickson, and K. Antonson Tumor induction with the N'-acetyl derivative of 4-hydroxlmethyl-phenyl hydrazine, a metabolite of agaritine of Agaricus bisporus Cancer Research 38 1978 177 180
33. B. Toth, K. Patil, and H.S. Jae Carcinogenesis of 4-(hydroxymethyl)- benzenediazonium ion (tetrafluoroborate) of Agaricus bisporus Cancer Research 41 1981 2444 2449 (Pubitemid 11111455)
34. S. Tsukagoshi, Y. Hashimoto, G. Fujii, H. Kobayashi, K. Nomoto, and K. Orita Krestin (PSK) Cancer Treatment Reviews 11 1984 131 155
35. S.P. Wasser Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides Applied Microbiology and Biotechnology 60 2002 258 274
36. L. Ziliotto, F. Pinheiro, L.F. Barbisan, and M.A. Rodrigues Screening for in vitro and in vivo antitumor activities of the mushroom Agaricus blazei Nutrition and Cancer 61 2009 245 250