Leishmania donovani: Assessment of leishmanicidal effects of herbal extracts obtained from plants in the visceral leishmaniasis endemic area of Bihar, India

Experimental Parasitology

Volumn 127, Issue 2, 2011, Pages 552-558

  Singh, Shubhankar K ^a   Bimal, Sanjiva ^a   Narayan, Shyam ^a   Jee, Chandrawati ^b   Bimal, Devla ^c   Das, P ^a   Bimal, Raageeva ^c  

^a RAJENDRA MEMORIAL RESEARCH INSTITUTE OF MEDICAL SCIENCES   (India)

^b MAGADH UNIVERSITY   (India)

^c B R A BIHAR UNIVERSITY   (India)

Author keywords

Anti leishmanial drugs; Axenic amastigotes; Herbal extracts; Leishmania donovani; Leishmanicidal effect; Medicinal plants; Promastigotes

Indexed keywords

AGAVE AMERICANA EXTRACT; AMPHOTERICIN B; ANTIMONY GLUCONATE; AZADIRACHTA INDICA EXTRACT; CONCANAVALIN A; CRUDE SOLUBLE ANTIGEN; ECLIPTA ALBA EXTRACT; PHYTOHEMAGGLUTININ; PIPER LONGUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

AGAVE AMERICANA; AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ECLIPTA ALBA; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMIDITY; LEISHMANIA DONOVANI; LEISHMANIASIS; MEDICINAL PLANT; NONHUMAN; PIPER LONGUM; PLANT LEAF; PRIORITY JOURNAL; PROMASTIGOTE;

AMPHOTERICIN B; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; CONCANAVALIN A; HUMANS; INDIA; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LEUKOCYTES, MONONUCLEAR; PHYTOHEMAGGLUTININS; PLANT EXTRACTS;

AGAVE AMERICANA; AZADIRACHTA INDICA; ECLIPTA PROSTRATA; LEISHMANIA DONOVANI; PIPER LONGUM;

EID: 78751575743     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.10.014     Document Type: Article

References (42)

1. Akendengue B., Ngou-Milama E., Laurens A., Hocquemiller R. Recent advances in the fight against leishmaniasis with natural products. Parasite 1999, 6:3-8.
2. Ashford R.W., Desjeux P., de Raadt P. Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitology Today 1992, 8:104-105.
3. Bafghi A.F., Noorbala M.T., Hejazian S.H. The Effect of Rubia tinctorium extract on cutaneous leishmaniasis in BALB/c Mice. World Journal of Zoology 2008, 3:25-29.
4. Bhattacharya S.K., Jha T.K., Sundar S., Thakur C.P., Engel J., Sindermann H., et al. Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India. Clinical Infectious Disease 2004, 38:217-221.
5. Biswas M., Ghosh A.K., Haldar P.K. Anti Leishmania and anti cancer activities of a pentacyclic triterpenoid isolated from the leaves of Terminalia arjuna Combretaceae. Tropical Journal of Pharmaceutical Research 2010, 9:135-140.
6. Bradley P.R. British Herbal Compendium 1992, British Herbal Medicine Association, Bournemouth, Dorset England, pp. 119-120.
7. Chattopadhyay R., Kaur S., Ganguly N.K., Mahajan R.C. Antigenic difference between axenic amastigotes and promastigotes of Leishmania donovani. Indian Journal of Medical Research 1996, 104:349-354.
8. Chenari M.A., Nazer A. The effect of cassia fistula extracts on Leishmania major ulcers in laboratory mice. Pajouhandeh 1999, 4:9-14.
9. Christybapita D., Divyagnaneswari M., Michael R.D. Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus. Fish Shellfish Immunology 2007, 23:840-852.
10. Delorenzi J.C., Attias M., Gattass C.R., Andrade M., Rezende C., Pinto A.C., Henriques A.T., Bou-Habib D.C., Saraiva E.M.B. Anti leishmanial activity of indol alkaloid from Peschiera australis. Antimicrobial Agents and Chemotherapy 2001, 45:1349-1354.
11. El-On J., Ozer L., Gopas J., Sneir R., Golan-Goldhirsh A. Nuphar lutea: in vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes. Phytomedecine 2009, 16:788-792.
12. Ferreira M.E., Arias A.R., Ortiz S.T., Inchausti A., Nakayama H., Thouvenel C., Hocquemiller R., Fournet A. Leishmanicidal activity of two cathin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. Angustifolia. Journal of Ethanopharmacology 2002, 80:199-202.
13. Fournet A., Angelo A., Munoz V., Roblot F., Hocquemiller R., Cave A. Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis. Journal of Ethnopharmacology 1992, 37:159-164.
14. Getti G., Durgadoss P., Dominguez-Carmona D., Martin-Quintal Z., Peraza-Sanchez S., Pena-Rodriguez L.M., Humber D. Leishmanicidal activity of Yucatecan medicinal plants on Leishmania species responsible for cutaneous leishmaniasis. Journal of Parasitology 2009, 95:456-460.
15. Ghosh A.K., Bhattacharya F.K., Ghosh D.K. Leishmania donovani: amastigotes inhibition and mode of action of berberine. Experimental Parasitology 1985, 60:404-413.
16. Iwu M.M., Jackson J.E., Schuster B.G. Medicinal plants in the fight against leishmaniasis. Parasitology Today 1994, 10:65-68.
17. Jaffe C.L., Grimaldi G., McMahon-Pratt D. The cultivation and cloning of Leishmania. Genes and Antigen of Parasites, A Laboratory Manual 1984, 47-91. Fundaco Oswaldo Curz, Brazil. second ed. C.N. Morel (Ed.).
18. Jayathirtha M.G., Mishra S.H. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004, 11:361-365.
19. Khalid F.A., Abdalla N.M., Mohomed H.E.O., Toum A.M., Magzoub M.M.A., Ali M.S. Treatment of cutaneous leishmaniasis with some local Sudanese plants (Neem, Garad & Garlic). Turkiye Parazitoloji Dergisi 2004, 28:129-132.
20. Kivcak B., Merti T., Ertabaklar H., Balcioglu C., Ozensoytoz S. In vitro activity of Arbutus unedo against Leishmania tropica promastigotes. Turkiye Parazitoloji Dergisi 2009, 33:114-115.
21. Lakshmi V., Pandey K., Kapil A., Singh N., Samant M., Dube A. In vitro and in vivo leishmanicidal activity of Dysoxylum binectariferum and its fractions against Leishmania donovani. Phytomedicine 2007, 14:36-42.
22. Luize P.S., Tiuman T.S., Morello L.G., Maza P.K., Ueda-Nakamura T., Dias Filho B.P., Cortez D.A.G., Palazzo de Mello J.C., Nakamura C.V. Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi. Brazilian Journal of Pharmaceutical Sciences 2005, 41:85-94.
23. Martin J.S., Reutelingsperger C.P.M., McGahon A.J., Rader J.A., van Schie R.C.A.A., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphotidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by over expression of Bcl-2 and Abl. Journal of Exerimental Medicine 1995, 182:1545-1556.
24. Mishra P.K., Singh N., Ahmad G., Dube A., Maurya R. Glycolipids and other constituents from Desmodium gangeticum with anti-leishmanial and immunomodulatory activities. Bioorganic & Medicinal Chemistry Letters 2005, 15:4543-4546.
25. Mossman T. Rapid chlorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunology Methods 1983, 65:55-63.
26. Peana A.T., Moretti M.D.L., Manconi V., Desole G., Pippia P. Anti-inflametry activity of aqueous extracts and steroidal sapogenins of Agave americana. Planta Medica 1997, 63:199-202.
27. Plock A., Kohler W.S., Presber W. Application of flow cytometry and microscopical methods to characterize the effect of herbal drugs on Leishmania spp. Experimental Parasitology 2001, 97:141-153.
28. Saar Y., Ramsford A., Waldman E., Mazareb S., Amin-Speitor S., Plumbee J., Turco S.J., Zilberstein D. Characterization of developmentally regulated activities in axenic amastigote of Leishmania donovani. Molecular Biochemistry and Parasitology 1998, 95:9-20.
29. Salvador M.J., Ferreira E.O., Pral E.M.F., Alfieri S.C., Lbuquerque S., Ito I.Y., Dias D.A. Bioactivity of crude extracts and some constituents of Blutaparon portulacoides (Amaranthaceae). Phytomedicine 2002, 9:566-571.
30. Sawant M., Isaac J.C., Narayanan S. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytotherapy Research 2004, 18:111-113.
31. Sharif M., Ziaei H., Azadbakht M., Daryani A., Ebadattalab A., Rostami M. Effect of methanolic extracts of Artemisia aucheri and Camellia sinensis on Leishmania major (in vitro). Turk Journal of Medical Science 2006, 36:365-369.
32. Singh S.K., Bimal S., Sinha P.K., Bimal R., Gupta A.K., Chanchal A., Bhattacharya S.K. Role of Azadirachta indica A. Juss. antigen in modulation of signal transduction for T-cell activation in VL. Journal of Immunology and Immunopathology 2004, 6:69-70.
33. Singh N., Mishra P.K., Kapil A., Arya K.R., Maurya R., Dube A. Efficacy of Desmodium gangeticum extract and its fractions against experimental visceral leishmaniasis. Journal of Ethnopharmacology 2005, 98:83-88.
34. Singha U.K., Guru P.Y., Sen A.B., Tandon J.S. Anti-leishmanial activity of traditional plants against Leishmania donovani in Golden Hamsters. Pharmaceutical Biology 1992, 30:289-295.
35. Sundar S., More D.K., Singh M.K., Singh V.P., Sharma S., Makharia A., Kumar P.C., Murray H.W. Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic. Clinical Infectious Diseases 2000, 31:1104-1107.
36. Thakur C.P., Sinha G.P., Pandey A.K., Kumar N., Kumar P., Hassan S.M., Narain S., Roy R.K. Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India; justify its continued use as a first line drug? An observational study of 80 cases. Annals of Tropical Medicine and Parasitology 1998, 92:561-569.
37. Torres-Santos E.C., Moreira D.L., Kaplan M.A.C., Meirelles M.N., Rossi-Bergmann B. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. Antimicrobial Agents and Chemotherapy 1999, 43:1234-1241.
38. Tremblay M., Olivier M., Bernier R. Leishmania and pathogenesis of HIV infection. Parasitology Today 1996, 7:257-261.
39. Vistica D., Skehan P., Scudiero D., Monks A., Pittman A., Boyd M.R. Tetrazolium based assay for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Research 1991, 51:2515-2520.
40. WHO Expert Committee, 1984. The leishmaniasis, WHO Technical Report Series 701(s), 2-4.
41. Wright C.W., Phillipson J.D. Natural products and the development of selective anti-protozoal drugs. Phytotherapy Research 1990, 4:127-139.
42. Yousefi R., Ghaffarifar F., Asl A.D. The effect of Alkanna tincturia and Peganum harmala extracts on Leishmania major (MRHO/IR/75/ER) in vitro. Iranian Journal of Parasitology 2009, 4:40-47.