Is the -174 C/G polymorphism of the IL6 gene associated with elite power performance? A replication study with two different Caucasian cohorts

Experimental Physiology

Volumn 96, Issue 2, 2011, Pages 156-162

  Eynon, Nir ^a   Ruiz, Jonatan R ^b   Meckel, Yoav ^a   Santiago, Catalina ^c   Fiuza Luces, Carmen ^c   Gómez Gallego, Félix ^c   Oliveira, José ^d   Lucia, Alejandro ^c  

^a WINGATE INSTITUTE   (Israel)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; ATHLETE; CAUCASIAN; DNA POLYMORPHISM; ENDURANCE; EXERCISE; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; ISRAEL; MALE; NORMAL HUMAN; PHENOTYPE; RACE DIFFERENCE; SEX DIFFERENCE; SPAIN;

EID: 78751564848     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2010.055442     Document Type: Article

References (38)

1. Amir O, Amir R, Yamin C, Attias E, Eynon N, Sagiv M, Sagiv M & Meckel Y (2007). The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol 92, 881-886.
2. Bamman MM, Shipp JR, Jiang J, Gower BA, Hunter GR, Goodman A, McLafferty CL Jr & Urban RJ (2001). Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinol Metab 280, E383-E390.
3. Bennermo M, Held C, Stemme S, Ericsson CG, Silveira A, Green F & Tornvall P (2004). Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 50, 2136-2140.
4. Cantini M, Massimino ML, Rapizzi E, Rossini K, Catani C, Dalla Libera L & Carraro U (1995). Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes. Biochem Biophys Res Commun 216, 49-53.
5. Costa AM, Silva AJ, Garrido ND, Louro H, de Oliveira RJ & Breitenfeld L (2009). Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol 106, 785-790.
6. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM & Collins FS (2007). Replicating genotype-phenotype associations. Nature 447, 655-660.
7. Denny MW (2008). Limits to running speed in dogs, horses and humans. J Exp Biol 211, 3836-3849.
8. Dhamrait SS, James L, Brull DJ, Myerson S, Hawe E, Pennell DJ, World M, Humphries SE, Haddad F & Montgomery HE (2003). Cortical bone resorption during exercise is interleukin-6 genotype-dependent. Eur J Appl Physiol 89, 21-25.
9. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S & Woo P (1998). The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102, 1369-1376.
10. Gómez-Gallego F, Ruiz JR, Buxens A, Altmäe S, Artieda M, Santiago C, González-Freire M, Verde Z, Arteta D, Martínez A, Tejedor D, Lao JI, Arenas J & Lucia A (2010). Are elite endurance athletes genetically predisposed to lower disease risk? Physiol Genomics 41, 82-90.
11. Goyenechea E, Parra D & Martínez JA (2007). Impact of interleukin 6 -174G>C polymorphism on obesity-related metabolic disorders in people with excess in body weight. Metabolism 56, 1643-1648.
12. Halverstadt A, Phares DA, Roth S, Ferrell RE, Goldberg AP & Hagberg JM (2005). Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise training. Biochim Biophys Acta 1734, 143-151.
13. Harriss DJ & Atkinson G (2009). International Journal of Sports Medicine - ethical standards in sport and exercise science research. Int J Sports Med 30, 701-702.
14. Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B & Richter EA (2003). The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546, 299-305.
15. Holm S (1979). A simple sequentially rejective multiple test procedure. Scand J Statist 6, 65-70.
16. Huth C, Illig T, Herder C, Gieger C, Grallert H, Vollmert C, Rathmann W, Hamid YH, Pedersen O, Hansen T, Thorand B, Meisinger C, Doring A, Klopp N, Gohlke H, Lieb W, Hengstenberg C, Lyssenko V, Groop L, Ireland H, Stephens JW, Wernstedt Asterholm I, Jansson JO, Boeing H, Mohlig M, Stringham HM, Boehnke M, Tuomilehto J, Fernandez-Real JM, Lopez-Bermejo A, Gallart L, Vendrell J, Humphries SE, Kronenberg F, Wichmann HE & Heid IM (2009). Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index. Ann Med 41, 128-138.
17. Kim CH, Cho JY, Jeon JY, Koh YG, Kim YM, Kim HJ, Park M, Um HS & Kim C (2010). ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med 31, 65-71.
18. McKay BR, De Lisio M, Johnston AP, O'Reilly CE, Phillips SM, Tarnopolsky MA & Parise G (2009). Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans. PLoS One 4, e6027.
19. McKay BR, O'Reilly CE, Phillips SM, Tarnopolsky MA & Parise G (2008). Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans. J Physiol 586, 5549-5560.
20. McKenzie JA, Weiss EP, Ghiu IA, Kulaputana O, Phares DA, Ferrell RE & Hagberg JM (2004). Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes. J Appl Physiol 97, 1338-1342.
21. Manginas A, Tsiavou A, Chaidaroglou A, Giamouzis G, Degiannis D, Panagiotakos D & Cokkinos DV (2008). Inflammatory cytokine gene variants in coronary artery disease patients in Greece. Coron Artery Dis 19, 575-582.
22. Mourkioti F & Rosenthal N (2005). IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol 26, 535-542.
23. Myerson S, Hemingway H, Budget R, Martin J, Humphries S & Montgomery H (1999). Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol 87, 1313-1316.
24. O'Reilly C, McKay B, Phillips S, Tarnopolsky M & Parise G (2008). Hepatocyte growth factor (HGF) and the satellite cell response following muscle lengthening contractions in humans. Muscle Nerve 38, 1434-1442.
25. Ortlepp JR, Metrikat J, Vesper K, Mevissen V, Schmitz F, Albrecht M, Maya-Pelzer P, Hanrath P, Weber C, Zerres K & Hoffmann R (2003). The interleukin-6 promoter polymorphism is associated with elevated leukocyte, lymphocyte, and monocyte counts and reduced physical fitness in young healthy smokers. J Mol Med 81, 578-584.
26. Panoulas VF, Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, Milionis HJ, Douglas KM, Nightingale P & Kitas GD (2009). Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking. Atherosclerosis 204, 178-183.
27. Ruiz JR, Arteta D, Buxens A, Artieda M, Gómez-Gallego F, Santiago C, Yvert T, Moran M & Lucia A (2010a). Can we identify a power-oriented polygenic profile? J Appl Physiol 108, 561-566.
28. Ruiz JR, Buxens A, Artieda M, Arteta D, Santiago C, Rodríguez-Romo G, Lao JI, Gómez-Gallego F & Lucia A (2010b). The -174 G/C polymorphism of the IL6 gene is associated with elite power performance. J Sci Med Sport 13, 549-553.
29. Serrano AL, Baeza-Raja B, Perdiguero E, Jardí M & Muñoz-Cánoves P (2008). Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab 7, 33-44.
30. Sie MP, Sayed-Tabatabaei FA, Oei HH, Uitterlinden AG, Pols HA, Hofman A, van Duijn CM & Witteman JC (2006). Interleukin 6 -174 g/c promoter polymorphism and risk of coronary heart disease: results from the Rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol 26, 212-217.
31. Terry CF, Loukaci V & Green FR (2000). Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275, 18138-18144.
32. Tomiya A, Aizawa T, Nagatomi R, Sensui H & Kokubun S (2004). Myofibers express IL-6 after eccentric exercise. Am J Sports Med 32, 503-508.
33. Tso AR, Merino JG & Warach S (2007). Interleukin-6 -174G/C polymorphism and ischemic stroke: a systematic review. Stroke 38, 3070-3075.
34. Van Damme R, Wilson RS, Vanhooydonck B & Aerts P (2002). Performance constraints in decathletes. Nature 415, 755-756.
35. 2+-dependent mechanisms. Am J Physiol Cell Physiol 293, C1139-C1147.
36. Woods D, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Jones A, Humphries S & Montgomery H (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet 108, 230-232.
37. Yamin C, Duarte JA, Oliveira JM, Amir O, Sagiv M, Eynon N, Sagiv M & Amir RE (2008). IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise. Eur J Appl Physiol 104, 579-586.
38. Yang SY & Goldspink G (2002). Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 522, 156-160.