ED50 and ED95 of intrathecal levobupivacaine with opioids for Caesarean delivery

British Journal of Anaesthesia

Volumn 106, Issue 2, 2011, Pages 215-220

  Bouvet, L ^a   Da Col, X ^b   Chassard, D ^b   Dalery F ^b   Ruynat, L ^b   Allaouchiche, B ^a   Dantony, E ^b,c   Boselli, E ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c UNIVERSITÉ DE LYON   (France)

Author keywords

Caesarean; effective dose; levobupivacaine; spinal anaesthesia

Indexed keywords

LEVOBUPIVACAINE; MORPHINE; SUFENTANIL; BUPIVACAINE; DRUG DERIVATIVE; LOCAL ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT;

ADULT; ARTICLE; CESAREAN SECTION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; ELECTIVE SURGERY; EPIDURAL ANESTHESIA; EPIDURAL CATHETER; FEMALE; HEMODYNAMIC PARAMETERS; HUMAN; MAJOR CLINICAL STUDY; MOTOR NERVE BLOCK; NAUSEA AND VOMITING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; TREATMENT FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; METHODOLOGY; OBSTETRIC ANESTHESIA; PREGNANCY; PROSPECTIVE STUDY;

ADULT; ANALGESICS, OPIOID; ANESTHESIA, EPIDURAL; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ANESTHETICS, LOCAL; BUPIVACAINE; CESAREAN SECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MORPHINE; PREGNANCY; PROSPECTIVE STUDIES; SUFENTANIL; YOUNG ADULT;

EID: 78751558967     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq296     Document Type: Article

References (29)

1. Bader AM, Tsen LC, Camann WR, Nephew E, Datta S. Clinical effects and maternal and fetal plasma concentrations of 0.5% epidural levobupivacaine versus bupivacaine for cesarean delivery. Anesthesiology 1999; 90: 1596-601
2. Benhamou D, Ghosh C, Mercier FJ. A randomized sequential allocation study to determine the minimum effective analgesic concentration of levobupivacaine and ropivacaine in patients receiving epidural analgesia for labor. Anesthesiology 2003; 99: 1383-6
3. Camorcia M, Capogna G, Columb MO. Minimum local analgesic doses of ropivacaine, levobupivacaine, and bupivacaine for intrathecal labor analgesia. Anesthesiology 2005; 102: 646-50
4. Vercauteren MP, Hans G, De Decker K, Adriaensen HA. Levobupivacaine combined with sufentanil and epinephrine for intrathecal labor analgesia: a comparison with racemic bupivacaine. Anesth Analg 2001; 93: 996-1000
5. Choi DH, Ahn HJ, Kim MH. Bupivacaine-sparing effect of fentanyl in spinal anesthesia for cesarean delivery. Reg Anesth Pain Med 2000; 25: 240-5
6. Chen X, Qian X, Fu F, Lu H, Bein B. Intrathecal sufentanil decreases the median effective dose (ED50) of intrathecal hyperbaric ropivacaine for caesarean delivery. Acta Anaesthesiol Scand 2009; 53: 1-7
7. Carvalho B, Durbin M, Drover DR, Cohen SE, Ginosar Y, Riley ET. The ED50 and ED95 of intrathecal isobaric bupivacaine with opioids for cesarean delivery. Anesthesiology 2005; 103: 606-12
8. Ginosar Y, Mirikatani E, Drover DR, Cohen SE, Riley ET. ED50 and ED95 of intrathecal hyperbaric bupivacaine coadministered with opioids for cesarean delivery. Anesthesiology 2004; 100: 676-82
9. Khaw KS, Ngan Kee WD, Wong EL, Liu JY, Chung R. Spinal ropivacaine for cesarean section: a dose-finding study. Anesthesiology 2001; 95: 1346-50
10. Camorcia M, Capogna G, Berritta C, Columb MO. The relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine. Anesth Analg 2007; 104: 904-7
11. Gautier P, De Kock M, Huberty L, Demir T, Izydorczic M, Vanderick B. Comparison of the effects of intrathecal ropivacaine, levobupivacaine, and bupivacaine for Caesarean section. Br J Anaesth 2003; 91: 684-9
12. Bremerich DH, Fetsch N, Zwissler BC, Meininger D, Gogarten W, Byhahn C. Comparison of intrathecal bupivacaine and levobupivacaine combined with opioids for Caesarean section. Curr Med Res Opin 2007; 23: 3047-54
13. Parpaglioni R, Frigo MG, Lemma A, Sebastiani M, Barbati G, Celleno D. Minimum local anaesthetic dose (MLAD) of intrathecal levobupivacaine and ropivacaine for Caesarean section. Anaesthesia 2006; 61: 110-5
14. Parpaglioni R, Baldassini B, Barbati G, Celleno D. Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required. Acta Anaesthesiol Scand 2009; 53: 1214-20
15. Mercier FJ, Riley ET, Frederickson WL, Roger-Christoph S, Benhamou D, Cohen SE. Phenylephrine added to prophylactic ephedrine infusion during spinal anesthesia for elective cesarean section. Anesthesiology 2001; 95: 668-74
16. Ngan Kee WD, Khaw KS, Ng FF. Prevention of hypotension during spinal anesthesia for cesarean delivery: an effective technique using combination phenylephrine infusion and crystalloid cohydration. Anesthesiology 2005; 103: 744-50
17. Nam JM. A simple approximation for calculating sample sizes for detecting linear trend in proportions. Biometrics 1987; 43: 701-5
18. Cuzick J. A Wilcoxon-type test for trend. Stat Med 1985; 4: 87-90
19. R development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2009. ISBN 3-900051-07-0. Available from http:// www.R-project.org
20. Russell IF. Levels of anaesthesia and intraoperative pain at caesarean section under regional block. Int J Obstet Anesth 1995; 4: 71-7
21. Management of postoperative pain in adults and children. Consensus conference, Paris, France, 12 December 1997. Ann Fr Anesth Reanim 17: 444-662
22. Lyons G, Columb M, Hawthorne L, Dresner M. Extradural pain relief in labour: bupivacaine sparing by extradural fentanyl is dose dependent. Br J Anaesth 1997; 78: 493-7
23. Lyons G, Columb M, Wilson RC, Johnson RV. Epidural pain relief in labour: potencies of levobupivacaine and racemic bupivacaine. Br J Anaesth 1998; 81: 899-901
24. Pace NL, Stylianou MP. Advances in and limitations of up-and-down methodology: a precis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology 2007; 107: 144-52
25. Dahlgren G, Hultstrand C, Jakobsson J, Norman M, Eriksson EW, Martin H. Intrathecal sufentanil, fentanyl, or placebo added to bupivacaine for cesarean section. Anesth Analg 1997; 85: 1288-93
26. Capogna G, Camorcia M, Columb MO. Minimum analgesic doses of fentanyl and sufentanil for epidural analgesia in the first stage of labor. Anesth Analg 2003; 96: 1178-82
27. Chassard D, Bruguerolle B. Chronobiology and anesthesia. Anesthesiology 2004; 100: 413-27
28. Chassard D, Duflo F, de Queiroz Siqueira M, Allaouchiche B, Boselli E. Chronobiology and anaesthesia. Curr Opin Anaesthesiol 2007; 20: 186-90
29. Debon R, Boselli E, Guyot R, Allaouchiche B, Lemmer B, Chassard D. Chronopharmacology of intrathecal sufentanil for labor analgesia: daily variations in duration of action. Anesthesiology 2004; 101: 978-82