Influence of novel KGFR tyrosine kinase inhibitors on KGF-mediated proliferation of breast cancer

Anticancer Research

Volumn 30, Issue 12, 2010, Pages 4883-4890

  Mehta, Meghna ^a   Kesinger, Jason W ^a   Zang, Xiao Ping ^a   Lerner, Megan L ^b   Brackett, Daniel J ^b   Brueggemeier, Robert W ^c   Li, Pui Kui ^c   Pento, J Thomas ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Breast cancer; Cell proliferation; Erk signaling; Keratinocyte growth factor; KGFR tyrosine kinase inhibitor; Metastasis prevention

Indexed keywords

GEFITINIB; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR;

ARTICLE; BREAST CANCER; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; DRUG ACTIVITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOLOCALIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBROBLAST GROWTH FACTOR 7; HUMANS; INDOLES; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE INHIBITORS; QUINOLONES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2;

EID: 78751549595     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S and Aaronson SA: Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 56: 802-806, 1989.
2. Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon G, Taylor WG, Fortney E, Sakata H, Finch PW and LaRochelle WJ: Keratinocyte growth factor. Cell Biol Int 19: 399-411, 1995.
3. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM and Aaronson SA: Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 59: 246-250, 1992.
4. Celli G, LaRochelle WJ, Mackem S, Sharp R and Merlino G: Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. Embo J 17: 1642-1655, 1998.
5. Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG and Rubin JS: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. Ann N Y Acad Sci 638: 62-77, 1991.
6. Bottaro DP, Rubin JS, Ron D, Finch PW, Florio C and Aaronson SA: Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem 265: 12767-12770, 1990.
7. Ulich TR, Yi ES, Cardiff R, Yin S, Bikhazi N, Biltz R, Morris CF and Pierce GF: Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. Am J Pathol 144: 862-868, 1994.
8. Kitsberg DI and Leder P: Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene 13: 2507-2515, 1996.
9. Zang XP, Lerner ML, Brackett DJ and Pento JT: Keratinocyte growth factor-mediated pattern of gene expression in breast cancer cells. Cancer Genomics Proteomics 1: 339-344, 2004.
10. Zang XP and Pento JT: Keratinocyte growth factor-induced motility of breast cancer cells. Clin Exp Metastasis 18: 573-580,2001.
11. Zang XP, Siwak D, Nguyen TX, Tari AM and Pento JT: KGFinduced motility of breast cancer cells is dependent on grb2 and erk 1, 2. Clin Exptl Metastasis 21: 437-443, 2004.
12. Taniguchi F, Harada T, Sakamoto Y, Yamauchi N, Yoshida S, Iwabe T and Terakawa N: Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. J Clin Endocrinol Metab 55: 773-780, 2003.
13. Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, Lu GH, Eliseenkova AV, Green D, Schlessinger J and Hubbard SR: Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Embo J 17: 5896-5904, 1998.
14. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR and Schlessinger J: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-960, 1997.
15. Mohammadi M, Schlessinger J and Hubbard SR: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 56: 577-587, 1996.
16. Hackett J, Xiao Z, Zang XP, Lerner ML, Bracken DJ, Brueggemeier RW, Li PK and Pento JT: Development of keratinocyte growth factor receptor tyrosine kinase inhibitors for the treatment of cancer. Anticancer Res 27: 3801-3806, 2007.
17. Zang XP, Lerner MR, Dunn ST, Brackett DJ and Pento JT: Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res 23: 4913-4919, 2003.
18. Koos RD, Banks PK, Inkster SE, Yue W and Brodie AM: Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcriptionpolymerase chain reaction. J Steroid Biochem Mol Biol 45: 217-225,1993.
19. Palmieri C, Roberts-Clark D, Assadi-Sabet A, Coope RC, O'Hare M, Sunters A, Hanby A, Slade MJ, Gomm JJ, Lam EW and Coombes RC: Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1 beta-induced paracrine growth factor for human breast cells. J Endocrinol 177: 65-81, 2003.
20. Hishikawa Y, Tamara N, Ejima K, Hayashi T and Koji T: Expression of keratinocyte growth factor and its receptor in human breast cancer: Its inhibitory role in the induction of apoptosis possibly through the overexpression of bc1-2. Arch Histol Cytol 67: 455-464, 2004.
21. Zang XP, Bullen EC, Manjeshwar S, Jupe ER, Howard EW and Pento JT: Enhanced motility of KGF-transfected breast cancer cells. Anticancer Res 26: 961-966, 2006.
22. Lochter A, Galosy S, Muschler J, Freedman N, Werb Z and Bissell MJ: Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol 139: 1861-1872, 1997.
23. Zang XP, Lerner ML, Brackett DJ and Pento JT: A comparison of keratinocyte growth factor receptor expression in breast and other cancer tissue. Breast Cancer Res Treat 52: 525, 2003.