Development of keratinocyte growth factor receptor tyrosine kinase inhibitors for the treatment of cancer

Anticancer Research

Volumn 27, Issue 6 B, 2007, Pages 3801-3806

  Hackett, John ^b   Xiao, Zili ^b   Zang, Xiao Ping ^a   Lerner, Megan L ^a   Brackett, Daniel J ^a   Brueggemeier, Robert W ^b   Li, Pui Kai ^b   Pento, J Thomas ^a,c  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Breast cancer; Cell migration; KGF; KGFR; Tyrosine kinase inhibitor

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; 3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; ANTINEOPLASTIC AGENT; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL MEMBRANE; CELL MOTILITY; CELL PROLIFERATION; CHEMOPROPHYLAXIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; METASTASIS; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING;

BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; DRUG DESIGN; HUMANS; IMMUNOHISTOCHEMISTRY; PROTEIN KINASE INHIBITORS; QUINOLONES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2;

EID: 37549000113     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S and Aaronson SA: Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 86: 802-806, 1989.
2. Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon G, Taylor WG, Fortney E, Sakata H, Finch PW et al: Keratinocyte growth factor. Cell Biol Int 19: 399-411, 1995.
3. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM and Aaronson SA: Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 89: 246-250, 1992.
4. Celli G, LaRochelle WJ, Mackem S, Sharp R and Merlino G: Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. Embo J 17: 1642-1655, 1998.
5. Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG and Rubin JS: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. Ann NY Acad Sci 638: 62-77, 1991.
6. Bottaro DP, Rubin JS, Ron D, Finch PW, Florio C and Aaronson SA: Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem 265: 12767-12770, 1990.
7. Kitsberg DI and Leder P: Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene 13: 2507-2515, 1996.
8. Zang XP, Lerner ML, Brackett DJ and Pento JT: Keratinocyte growth factor-mediated pattern of gene expression in breast cancer cells. Cancer Genomics Proteomics 1: 339-344, 2004.
9. Zang XP and Pento JT: Keratinocyte growth factor-induced motility of breast cancer cells. Clin Exp Metastasis 18: 573-580, 2001.
10. Zang XP, Siwak D, Nguyen TX, Tari AM and Pento JT: KGF-induced motility of breast cancer cells is dependent on Grb2 and Erk1,2. Clin Exptl Metastasis 21: 437-443, 2004.
11. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D and Schlessinger J: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70: 431-442, 1992.
12. Rozakis-Adcock M, Fernley R, Wade J, Pawson T and Bowtell D: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363: 83-85, 1993.
13. Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B and Schlessinger J: The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260: 1953-1955, 1993.
14. Taniguchi F, Harada T, Sakamoto Y, Yamauchi N, Yoshida S, Iwabe T and Terakawa N: Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. J Clin Endocrinol Metab 88: 773-780, 2003.
15. Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, Lu GH, Eliseenkova AV, Green D, Schlessinger J and Hubbard SR: Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Embo J 17: 5896-5904, 1998.
16. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR and Schlessinger J: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-960, 1997.
17. Mohammadi M, Schlessinger J and Hubbard SR: Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 86: 577-587, 1996.
18. Nguyen TN, Zang XP and Pento JT: Keratinocyte growth factor stimulates the migration and proliferation of breast cancer cells in a culture wounding model. Pharmacol Res 46: 179-183, 2002.
19. Zang XP, Nguyen TN and Pento JT: Specific and non-specific KGF inhibition of KGF-induced breast cancer cell motility. Anticancer Res 22: 2539-2545, 2002.
20. Zang XP, Lerner MR, Dunn ST, Brackett DJ and Pento JT: Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res 23: 4913-4919, 2003.