Lymphatic vessel distribution in the mucosa and submucosa and potential implications for T1 Colorectal tumors

Diseases of the Colon and Rectum

Volumn 54, Issue 1, 2011, Pages 35-40

  Smith, Katherine J E ^a,b   Jones, Pamela F ^a   Burke, Dermot A ^b   Treanor, Darren ^a   Finan, Paul J ^b   Quirke, Philip ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Lymphatics; T1 colorectal cancer

Indexed keywords

ADULT; AGED; ARTICLE; COLORECTAL TUMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; MALE; MORBIDITY; STOMACH MUCOSA;

EID: 78751529424     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e3181fb0e7a     Document Type: Article

References (23)

1. Taylor EM, Thomas EJ, Quirke JD, et al. Major improvements in the stage profile of tumours diagnosed in the NHS bowel cancer screening programme. Gut. 2010;59: A31.
2. McArdle CS, Hole D. Impact of variability among surgeons on postoperative morbidity and mortality and ultimate survival. BMJ. 1991;302:1501-1505.
3. Brown SC, Abraham JS, Walsh S, Sykes PA. Risk factors and operative mortality in surgery for colorectal cancer. Ann R Coll Surg Engl. 1991;73:269-272.
4. Gallina S, Proposito D, Veltri S, Montemurro LA, Negro P, Carboni M. Colorectal cancer surgery: analysis of risk factors in relation to incidence of morbidity and mortality [in Italian]. Chir Ital. 2006;58:723-732.
5. Kikuchi R, Takano M, Takagi K, et al. Management of early invasive colorectal cancer: risk of recurrence and clinical guidelines. Dis Colon Rectum. 1995;38:1286-1295.
6. Blumberg D, Paty PB, Guillem JG, et al. All patients with small intramural rectal cancers are at risk for lymph node metastasis. Dis Colon Rectum. 1999;42:881-885.
7. Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR. Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum. 2002;45:200-206.
8. Liang P, Hong JW, Ubukata H, et al. Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma. Virchows Arch. 2006;448:570-575.
9. World Health Organization. Cancer research UK statistics 2009. http://info.cancerresearchuk.org/cancerstats/types/bowel/survival/#stage.
10. Ueno H, Mochizuki H, Hashiguchi Y, et al. Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology. 2004;127:385-394.
11. Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD. Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology. 1985;89:328-336.
12. Tominaga KNY, Nimura S, Yoshimura K, Sakai Y, Shimoda T. Predictive histopathological factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Dis Colon Rectum. 2005;48:92-100.
13. Okuyama T, Oya M, Ishikawa H. Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma. Dis Colon Rectum. 2002;45:628-634.
14. Bono P, Wasenius VM, Heikkilä P, Lundin J, Jackson DG, Joensuu H. High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin Cancer Res. 2004;10:7144-7149.
15. Mohammed RA, Martin SG, Gill MS, Green AR, Paish EC, Ellis IO. Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences. Am J Surg Pathol. 2007;31:1825-1833.
16. Roma AA, Magi-Galluzzi C, Kral MA, Jin TT, Klein EA, Zhou M. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Mod Pathol. 2006;19:392-398.
17. Fogt F, Zimmerman RL, Ross HM, Daly T, Gausas RE. Identification of lymphatic vessel sinmalignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep. 2004;11:47-50.
18. Fenoglio CM, Kaye GI, Lane N. Distribution of human colonic lymphatics in normal, hyperplastic, and adenomatous tissue: its relationship to metastasis from small carcinomas in pedunculated adenomas, with two case reports. Gastroenterology. 1973;64:51-66.
19. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 1991;324:1-8.
20. Chen W, Chen M, Liao Z, Wang Y, Zhan Q, Cai G. Lymphatic vessel density as predictive marker for the local recurrence of rectal cancer. Dis Colon Rectum. 2009;52:513-519.
21. Saad RS, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF. Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod Pathol. 2006;19:1317-1323.
22. Kenney BC, Jain D. Identification of lymphatics within the colonic lamina propria in inflammation and neoplasia using the monoclonal antibody D2-40. Yale J Biol Med. 2008;81:103-113.
23. Matsumoto K, Nakayama Y, Inoue Y, et al. Lymphatic microvessel density is an independent prognostic factor in colorectal cancer. Dis Colon Rectum. 2007;50:308-314.