Detection of endogenous steroid abuse in cattle: Results from population studies in the UK

Food Additives and Contaminants - Part A

Volumn 28, Issue 1, 2011, Pages 44-61

  Scarth, J P ^a   Clarke, A ^a   Teale, P ^a   Mill, A ^b   Macarthur, R ^b   Kay, J ^c  

^a LGC   (United Kingdom)

^b FOOD AND ENVIRONMENT RESEARCH AGENCY   (United Kingdom)

^c Veterinary Medicines Directorate   (United Kingdom)

Author keywords

Anabolic steroids; Animal; Gas chromatography; Gas chromatography mass spectrometry; High performance liquid chromatography; Liquid chromatography mass spectrometry; Veterinary drug residues

Indexed keywords

ANIMALS; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPIDS; MASS SPECTROMETRY; METABOLITES; POPULATION STATISTICS;

ANABOLIC STEROID; CHEBYSHEV INEQUALITIES; GAS CHROMATOGRAPHY COMBUSTION-ISOTOPE RATIO MASS SPECTROMETRY; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; GROWTH PROMOTING AGENTS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; THRESHOLD CONCENTRATIONS; VETERINARY DRUG RESIDUE;

GAS CHROMATOGRAPHY;

STEROID;

ARTICLE; CATTLE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; UNITED KINGDOM;

ANIMALIA; BOS;

EID: 78751507975     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2010.539628     Document Type: Article

References (23)

1. Aron C. 1979. Mechanisms of control of the reproductive function by olfactory stimuli in female mammals. Physiol Rev. 59(2):229-284.
2. Biddle S. 2003. Unpublished studies on the natural occurrence of androgens and estrogens in bovine plasma, urine and bile and the effect of exogenous steroid administration on these profiles (HFL study HFL086). Work carried out at HFL Ltd, UK.
3. Biddle S. 2005. Unpublished studies on the natural occurrence of boldenone in bovine urine and the metabolism of boldenone after administration (HFL study HFL1382). Work carried out at HFL Ltd, UK.
4. Biddle S, Teale P, Robinson A, Bowman J, Houghton E. 2007. Gas chromatography-mass spectrometry/mass spectrometry analysis to determine natural and postadministration levels of oestrogens in bovine serum and urine. Analyt Chim Acta. 586(1-2):115-121.
5. Boyer S, Garcia P, Popot MA, Steiner V, Lesieur M. 2007. Detection of testosterone propionate administration in horse hair samples. J Chromatogr B. 852:684-688.
6. De Brabander HF, Poelmans S, Schilt R, Stephany RW, Le Bizec B, Draisci R, Sterk SS, van Ginkel LA, Courtheyn D, Van Hoof N, et al. 2004. Presence and metabolism of the anabolic steroid boldenone in various animal species: a review. Food Addit Contam A. 21(6):515-525.
7. De Brabander HF, van Hende J, Batjoens P, Hendriks L, Raus J, Smets F, Pottie G, van Ginkel LA, Stephany RW. 1994. Endogenic nortestosterone in cattle? Analyst. 119(12):2581-2585.
8. Estler WT. 1997. A distribution-independent bound on the level of confidence in the result of a measurement. J Res Natl Instit Standard Tech. 102(5):587-588.
9. European Commission, Health and Consumer Protection Directorate-General. 2003. Outcome of the experts meeting on the control of Boldenone in veal calves, 30 September 2003, Brussels; p. 1-3.
10. European Union. 1996. Council Directive 96/22/EC of 29 April 1996 concerning the prohibition on the use in stock farming of certain substances having a hormonal or thyrostatic action and of beta-agonists, and replacing Directives 81/602/EEC, 88/146/EEC and 88/299/EEC. Off J Eur Union. L125:3-9.
11. European Union. 2002. Commission Decision (2002/57/EC) of 12 August 2002. Off J Eur Comm. L221:8-36.
12. Gray BP, Teale P, Pearce CM. 2010. Analysis of methyloxime derivatives of intact esters of testosterone and boldenone in equine plasma using ultra high pressure liquid chromatography tandem mass spectrometry. Drug Testing Anal. (in press).
13. Hadley ME, Levine J. 2006. Endocrinology. 6th ed. Upper Saddle River (NJ, USA): Prentice Hall.
14. Heitzman RJ. 1994. Veterinary drug residues: residues in food producing animals and their products: reference materials and methods. Oxford (UK): Blackwell.
15. Houghton E, Crone DL. 2000. The approaches adopted by the racing industry to address endogenous substances and substances of dietary origin. Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, Cambridge, UK; p. 23-26.
16. Kennedy GD, Shortt HD, Crooks SRH, Young PB, Price HJ, Smyth WG, Hewitt SA. 2009. Occurrence of α- and β-nortestosterone residues in the urine of injured male cattle. Food Addit Contam A. 26(5):683-691.
17. Manly BJF. 2007. Randomization, bootstrap and Monte Carlo methods in biology. 3rd ed. Boca Raton (FL, USA): Chapman and Hall/CRC.
18. Mareck U, Geyer H, Flenker U, Piper T, Thevis M, Schä nzer W. 2007. Detection of dehydroepiandrosterone misuse by means of gas chromatography-combustionisotope ratio mass spectrometry. Eur J Mass Spectrom. 13(6):419-426.
19. Pinel G, Rambaud L, Monteau F, Elliot C, Le Bizec B. 2010. Estranediols profiling in calves' urine after 17 β -nandrolone laureate ester administration. J Steroid Biochem Mol Biol. 121(3-5):626-632.
20. Plusquellec P, Bouissou M. 2001. Behavioural characteristics of two dairy breeds of cows selected (Hérens) or not (Brune des Alpes) for fighting and dominance ability. Appl Anim Behav Sci. 72(1):1-21.
21. Prévost S, Buisson C, Monteau F, Andre F, Le Bizec B. 2004. Is GC-C-IRMS a possible analytical approach to clear up misuse situations for forbidden natural substances in edible tissues? Euroresidue. 5:777-782.
22. Scarth J, Akre C, van Ginkel L, Le Bizec B, De Brabander H, Korth W, Points J, Teale P, Kay J. 2009. The presence and metabolism of endogenous androgenic-anabolic steroid hormones in meat producing animals. A review. Food Addit Contam A. 26(5):640-671.
23. Scarth J, Clarke A, Hands J, Teale P, Macarthur R, Kay J. 2010. Validation of a quantitative multi-residue urinary assay for the detection of androgen, oestrogen and progestagen abuse in the bovine. Chromatographia. 71:241-252.