Effects of graded heat stress on global left ventricular function and twist mechanics at rest and during exercise in healthy humans

Experimental Physiology

Volumn 96, Issue 2, 2011, Pages 114-124

  Stöhr, Eric J ^a   González Alonso, José ^a   Pearson, James ^a   Low, David A ^a   Ali, Leena ^b   Barker, Horace ^b   Shave, Rob ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b EALING HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BODY TEMPERATURE; EXERCISE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FUNCTION; HEART OUTPUT; HEART RATE; HEAT ACCLIMATIZATION; HEAT STRESS; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; REST;

EID: 78751487966     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2010.055137     Document Type: Article

References (46)

1. Akagawa E, Murata K, Tanaka N, Yamada H, Miura T, Kunichika H, Wada Y, Hadano Y, Tanaka T, Nose Y, Yasumoto K, Kono M & Matsuzaki M (2007). Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects: quantitative assessment utilizing a novel automated tissue tracking technique. Circ J 71, 661-668.
2. Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER & Omens JH (2007). Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol 49, 909-916.
3. Ashikaga H, Criscione JC, Omens JH, Covell JW & Ingels NB Jr (2004). Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol 286, H640-H647.
4. Brothers RM, Bhella PS, Shibata S, Wingo JE, Levine BD & Crandall CG (2009). Cardiac systolic and diastolic function during whole body heat stress. Am J Physiol Heart Circ Physiol 296, H1150-H1156.
5. Burns AT, La Gerche A, Prior DL & MacIsaac AI (2009). Left ventricular untwisting is an important determinant of early diastolic function. JACC Cardiovasc Imaging 2, 709-716.
6. Burns AT, La Gerche A, Prior DL & MacIsaac AI (2010). Left ventricular torsion parameters are affected by acute changes in load. Echocardiography 27, 407-414.
7. Crandall CG, Wilson TE, Marving J, Vogelsang TW, Kjaer A, Hesse B & Secher NH (2008). Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol 586, 293-301.
8. Dong SJ, Hees PS, Huang WM, Buffer SA Jr, Weiss JL & Shapiro EP (1999). Independent effects of preload, afterload, and contractility on left ventricular torsion. Am J Physiol Heart Circ Physiol 277, H1053-H1060.
9. Dong SJ, Hees PS, Siu CO, Weiss JL & Shapiro EP (2001). MRI assessment of LV relaxation by untwisting rate: a new isovolumic phase measure of Τ. Am J Physiol Heart Circ Physiol 281, H2002-H2009.
10. González-Alonso J & Calbet JA (2003). Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation 107, 824-830.
11. González-Alonso J, Crandall CG & Johnson JM (2008a). The cardiovascular challenge of exercising in the heat. J Physiol 586, 45-53.
12. González-Alonso J, Mortensen SP, Jeppesen TD, Ali L, Barker H, Damsgaard R, Secher NH, Dawson EA & Dufour SP (2008b). Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function. J Physiol 586, 2405-2417.
13. Granzier HL & Labeit S (2004). The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circ Res 94, 284-295.
14. Hardy JD & Dubois EF (1937). Regulation of heat loss from the human body. Proc Natl Acad Sci USA 23, 624-631.
15. Hardy JD & Stolwijk JA (1966). Partitional calorimetric studies of man during exposures to thermal transients. J Appl Physiol 21, 1799-1806.
16. Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JA, Torp H, Ihlen H & Smiseth OA (2005). New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation 112, 3149-3156.
17. Helmes M, Lim CC, Liao R, Bharti A, Cui L & Sawyer DB (2003). Titin determines the Frank-Starling relation in early diastole. J Gen Physiol 121, 97-110.
18. Lafrenz AJ, Wingo JE, Ganio MS & Cureton KJ (2008). Effect of ambient temperature on cardiovascular drift and maximal oxygen uptake. Med Sci Sports Exerc 40, 1065-1071.
19. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John Sutton M & Stewart W (2006). Recommendations for chamber quantification. Eur J Echocardiogr 7, 79-108.
20. Morris JJ 3rd, Pellom GL, Murphy CE, Salter DR, Goldstein JP & Wechsler AS (1987). Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart. Circulation 76, 717-727.
21. Mortensen SP, Gonzalez-Alonso J, Damsgaard R, Saltin B & Hellsten Y (2007). Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg. J Physiol 581, 853-861.
22. Nelson MD, Haykowsky MJ, Petersen SR, DeLorey DS, Cheng-Baron J & Thompson RB (2010a). Increased left ventricular twist, untwisting rates, and suction maintain global diastolic function during passive heat stress in humans. Am J Physiol Heart Circ Physiol 298, H930-H937.
23. Nelson MD, Haykowsky MJ, Petersen SR, Delorey DS, Stickland MK, Cheng-Baron J & Thompson RB (2010b). Aerobic fitness does not influence the biventricular response to whole-body passive heat stress. J Appl Physiol, In press.
24. Notomi Y, Lysyansky P, Setser RM, Shiota T, Popovic ZB, Martin-Miklovic MG, Weaver JA, Oryszak SJ, Greenberg NL, White RD & Thomas JD (2005). Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol 45, 2034-2041.
25. Notomi Y, Martin-Miklovic MG, Oryszak SJ, Shiota T, Deserranno D, Popovic ZB, Garcia MJ, Greenberg NL & Thomas JD (2006). Enhanced ventricular untwisting during exercise: a mechanistic manifestation of elastic recoil described by Doppler tissue imaging. Circulation 113, 2524-2533.
26. Notomi Y, Popovic ZB, Yamada H, Wallick DW, Martin MG, Oryszak SJ, Shiota T, Greenberg NL & Thomas JD (2008). Ventricular untwisting: a temporal link between left ventricular relaxation and suction. Am J Physiol Heart Circ Physiol 294, H505-H513.
27. Nottin S, Doucende G, Schuster-Beck I, Dauzat M & Obert P (2008). Alteration in left ventricular normal and shear strains evaluated by 2D-strain echocardiography in the athlete's heart. J Physiol 586, 4721-4733.
28. Opdahl A, Helle-Valle T, Remme EW, Vartdal T, Pettersen E, Lunde K, Edvardsen T & Smiseth OA (2008). Apical rotation by speckle tracking echocardiography: a simplified bedside index of left ventricular twist. J Am Soc Echocardiogr 21, 1121-1128.
29. Perry R, De Pasquale CG, Chew DP & Joseph MX (2008). Assessment of early diastolic left ventricular function by two-dimensional echocardiographic speckle tracking. Eur J Echocardiogr 9, 791-795.
30. Popovic ZB, Prasad A, Garcia MJ, Arbab-Zadeh A, Borowski A, Dijk E, Greenberg NL, Levine BD & Thomas JD (2006). Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness. Am J Physiol Heart Circ Physiol 290, H1454-H1459.
31. Rowell LB (1974). Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev 54, 75-159.
32. Rowell LB (1990). Hyperthermia: a hyperadrenergic state. Hypertension 15, 505-507.
33. Rowell LB, Brengelmann GL & Murray JA (1969a). Cardiovascular responses to sustained high skin temperature in resting man. J Appl Physiol 27, 673-680.
34. Rowell LB, Marx HJ, Bruce RA, Conn RD & Kusumi F (1966). Reductions in cardiac output, central blood volume, and stroke volume with thermal stress in normal men during exercise. J Clin Invest 45, 1801-1816.
35. Rowell LB, Murray JA, Brengelmann GL & Kraning KK 2nd (1969b). Human cardiovascular adjustments to rapid changes in skin temperature during exercise. Circ Res 24, 711-724.
36. Savard GK, Nielsen B, Laszczynska J, Larsen BE & Saltin B (1988). Muscle blood flow is not reduced in humans during moderate exercise and heat stress. J Appl Physiol 64, 649-657.
37. Taber LA, Yang M & Podszus WW (1996). Mechanics of ventricular torsion. J Biomech 29, 745-752.
38. Takeuchi M & Lang RM (2008). Reduced and delayed untwisting of the left ventricle in patients with hypertension and left ventricular hypertrophy: a study using two-dimensional speckle tracking imaging: reply. Eur Heart J 29, 825-826.
39. Takeuchi M, Otsuji Y & Lang RM (2009). Evaluation of left ventricular function using left ventricular twist and torsion parameters. Curr Cardiol Rep 11, 225-230.
40. Teichholz LE, Kreulen T, Herman MV & Gorlin R (1976). Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol 37, 7-11.
41. Teske AJ, De Boeck BW, Melman PG, Sieswerda GT, Doevendans PA & Cramer MJ (2007). Echocardiographic quantification of myocardial function using tissue deformation imaging, a guide to image acquisition and analysis using tissue Doppler and speckle tracking. Cardiovasc Ultrasound 5, 27.
42. van Dalen BM, Vletter WB, Soliman OI, ten Cate FJ & Geleijnse ML (2008). Importance of transducer position in the assessment of apical rotation by speckle tracking echocardiography. J Am Soc Echocardiogr 21, 895-898.
43. Wang J, Khoury DS, Yue Y, Torre-Amione G & Nagueh SF (2007). Left ventricular untwisting rate by speckle tracking echocardiography. Circulation 116, 2580-2586.
44. Weidemann F, Jamal F, Sutherland GR, Claus P, Kowalski M, Hatle L, De Scheerder I, Bijnens B & Rademakers FE (2002). Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate. Am J Physiol Heart Circ Physiol 283, H792-H799.
45. Wilson TE, Brothers RM, Tollund C, Dawson EA, Nissen P, Yoshiga CC, Jons C, Secher NH & Crandall CG (2009). Effect of thermal stress on Frank-Starling relations in humans. J Physiol 587, 3383-3392.
46. Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH & Crandall CG (2007). Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol 585, 279-285.