메뉴 건너뛰기




Volumn 33, Issue 11, 2010, Pages 1761-1769

A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia

Author keywords

Half life time; Hyperuricemia; Mathematic modeling; Pharmacodynamics; Pharmacokinetics; Uricase

Indexed keywords

MACROGOL; MACROGOL 5000; UNCLASSIFIED DRUG; URATE OXIDASE; URIC ACID;

EID: 78751476321     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1108-2     Document Type: Article
Times cited : (16)

References (47)
  • 1
    • 61349127856 scopus 로고    scopus 로고
    • Association of uric acid with inflamma-tion, progressive renal allograft dysfunction and post-transplant cardiovascular risk
    • Bandukwala, F., Huang, M., Zaltzman, J. S., Nash, M. M., and Prasad, G. V., Association of uric acid with inflamma-tion, progressive renal allograft dysfunction and post-transplant cardiovascular risk. Am. J. Cardiol., 103, 867-871 (2009).
    • (2009) Am. J. Cardiol. , vol.103 , pp. 867-871
    • Bandukwala, F.1    Huang, M.2    Zaltzman, J.S.3    Nash, M.M.4    Prasad, G.V.5
  • 2
    • 4243337412 scopus 로고
    • Studies on uri-case. II. the enzyme-substrate complex
    • Baum, H., Hubsche, G., and Mahler, H. R., Studies on uri-case. II. The enzyme-substrate complex. Biochim. Biophys. Acta, 22, 514-527 (1956).
    • (1956) Biochim. Biophys. Acta , vol.22 , pp. 514-527
    • Baum, H.1    Hubsche, G.2    Mahler, H.R.3
  • 4
    • 41949098852 scopus 로고    scopus 로고
    • Pegloticase a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout
    • Biggers, K. and Scheinfeld, N., Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout. Curr. Opin. Investig. Drugs, 9, 422-429 (2008).
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 422-429
    • Biggers, K.1    Scheinfeld, N.2
  • 5
    • 0036735357 scopus 로고    scopus 로고
    • Uricase formulated with polyethylene glycol (uricase-PEG 20): Biochemical rationale and preclinical studies
    • Bomalaski, J. S., Holtsberg, F. W., Ensor, C. M., and Clark, M. A., Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J. Rheumatol., 29, 1942-1949 (2002).
    • (2002) J. Rheumatol. , vol.29 , pp. 1942-1949
    • Bomalaski, J.S.1    Holtsberg, F.W.2    Ensor, C.M.3    Clark, M.A.4
  • 6
    • 4644275038 scopus 로고    scopus 로고
    • Serum uric acid-lowering therapies: Where are we heading in management of hyper-uricemia and the potential role of uricase
    • Bomalaski, J. S. and Clark, M. A., Serum uric acid-lowering therapies: where are we heading in management of hyper-uricemia and the potential role of uricase. Curr. Rheu-matol. Rep., 6, 240-247 (2004).
    • (2004) Curr. Rheu-matol. Rep. , vol.6 , pp. 240-247
    • Bomalaski, J.S.1    Clark, M.A.2
  • 7
    • 0018162586 scopus 로고
    • Uricase of Bacillus fastidiosus: Properties and regulation of synthesis
    • Bongaerts, G. P. A., Uitzetter, J., Brouns, R., and Vogels, G. D., Uricase of Bacillus fastidiosus: properties and regulation of synthesis. Biochem. Biophys. Acta, 527, 348-358 (1978).
    • (1978) Biochem. Biophys. Acta , vol.527 , pp. 348-358
    • Bongaerts, G.P.A.1    Uitzetter, J.2    Brouns, R.3    Vogels, G.D.4
  • 8
    • 36849050185 scopus 로고    scopus 로고
    • Methemoglo-binemia and hemolytic anemia caused by rasburicase ad-ministration in a newly diagnosed child with Burkitt lym-phoma/leukemia
    • Borinstein, S. C., Xu, M., and Hawkins, D. S., Methemoglo-binemia and hemolytic anemia caused by rasburicase ad-ministration in a newly diagnosed child with Burkitt lym-phoma/leukemia. Pediatr. Blood Cancer, 50, 189 (2008).
    • (2008) Pediatr. Blood Cancer , vol.50 , pp. 189
    • Borinstein, S.C.1    Xu, M.2    Hawkins, D.S.3
  • 9
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the qu-antitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M., A rapid and sensitive method for the qu-antitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 10
    • 27344455353 scopus 로고    scopus 로고
    • Hemolysis and methemo-globinemia secondary to rasburicase administration
    • Browning, L. A. and Kruse, J. A., Hemolysis and methemo-globinemia secondary to rasburicase administration. Ann. Pharmacother., 39, 1932-1935 (2005).
    • (2005) Ann. Pharmacother. , vol.39 , pp. 1932-1935
    • Browning, L.A.1    Kruse, J.A.2
  • 11
    • 62349137054 scopus 로고    scopus 로고
    • Update on emerging urate-lowering therapies
    • Chohan, S. and Becker, M. A., Update on emerging urate-lowering therapies. Curr. Opin. Rheumatol., 21, 143-149 (2009).
    • (2009) Curr. Opin. Rheumatol. , vol.21 , pp. 143-149
    • Chohan, S.1    Becker, M.A.2
  • 12
    • 0019021458 scopus 로고
    • Thermodynamics and stoichio-metry of the binding of substrate analogues to uricase
    • Conley, T. G. and Priest, D. G., Thermodynamics and stoichio-metry of the binding of substrate analogues to uricase. Biochem. J., 187, 727-732 (1980).
    • (1980) Biochem. J. , vol.187 , pp. 727-732
    • Conley, T.G.1    Priest, D.G.2
  • 13
    • 33847028671 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling: Biophase distribution, receptor theory, and dynamical systems an-alysis
    • Danhof, M., de Jongh, J., De Lange, E. C., Della Pasqua, O. E., Ploeger, B. A., and Voskuyl, R. A., Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems an-alysis. Annu. Rev. Pharmacol. Toxicol., 47, 357-400 (2007).
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 357-400
    • Danhof, M.1    De Jongh, J.2    De Lange, E.C.3    Della Pasqua, O.E.4    Ploeger, B.A.5    Voskuyl, R.A.6
  • 14
    • 41349119550 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research
    • Danhof, M., de Lange, E. C, Della Pasqua, O. E., Ploeger, B. A., and Voskuyl, R. A., Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research. Trends Pharmacol. Sci., 29, 186-191 (2008).
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 186-191
    • Danhof, M.1    De Lange, E.C.2    Della Pasqua, O.E.3    Ploeger, B.A.4    Voskuyl, R.A.5
  • 16
    • 0026082596 scopus 로고
    • Hemolytic anemia due to G6PD defi-ciency and urate oxidase in a kidney-transplant patient
    • Ducros, J., Saingra, S., Rampal, M., Coulange, C., Barbe, M. C., and Verzetti, G., Hemolytic anemia due to G6PD defi-ciency and urate oxidase in a kidney-transplant patient. Clin. Nephrol., 35, 89-90 (1991).
    • (1991) Clin. Nephrol. , vol.35 , pp. 89-90
    • Ducros, J.1    Saingra, S.2    Rampal, M.3    Coulange, C.4    Barbe, M.C.5    Verzetti, G.6
  • 17
    • 54949100735 scopus 로고    scopus 로고
    • Uric acid and car-diovascular risk
    • Feig, D. I., Kang, D. H., and Johnson, R. J., Uric acid and car-diovascular risk. N. Engl. J. Med., 359, 1811-1821 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1811-1821
    • Feig, D.I.1    Kang, D.H.2    Johnson, R.J.3
  • 18
    • 0000209495 scopus 로고
    • The competitive inhibition of uricase by oxon-ate and by related derivatives of s-triazines
    • Fridovich, I., The competitive inhibition of uricase by oxon-ate and by related derivatives of s-triazines. J. Biol. Chem., 240, 2491-2494 (1965).
    • (1965) J. Biol. Chem. , vol.240 , pp. 2491-2494
    • Fridovich, I.1
  • 19
    • 39749173047 scopus 로고    scopus 로고
    • A new linearly-combined bi-expo-nential model for kinetic analysis of the isometric relaxa-tion process of Bufo gastrocnemius under electric stimula-tion in vitro
    • Guo, R, Li, S. B., Zhao, L. N, Zhao, Y. S, Lu, W, Yuan, P., Deng, P., and Liao F., A new linearly-combined bi-expo-nential model for kinetic analysis of the isometric relaxa-tion process of Bufo gastrocnemius under electric stimula-tion in vitro. J. Zhejiang Univ. Sci. B, 8, 867-874 (2007).
    • (2007) J. Zhejiang Univ. Sci. B , vol.8 , pp. 867-874
    • Guo, R.1    Li, S.B.2    Zhao, L.N.3    Zhao, Y.S.4    Lu, W.5    Yuan, P.6    Deng, P.7    Liao, F.8
  • 20
    • 0018648312 scopus 로고
    • Hy-perxanthinemia interferes with serum uric acid deter-minations by the uricase method
    • Hande, K. R., Perini, F., Putterman, G. J., and Elm, R., Hy-perxanthinemia interferes with serum uric acid deter-minations by the uricase method. Clin. Chem., 25, 1492-1494 (1979).
    • (1979) Clin. Chem. , vol.25 , pp. 1492-1494
    • Hande, K.R.1    Perini, F.2    Putterman, G.J.3    Elm, R.4
  • 21
    • 11844278229 scopus 로고    scopus 로고
    • Efficacy and safety of rasburicase, a recombinant urate oxidase (Elitek), in the management of malignancy-associated hyperuricemia in pediatric and adult patients: Final results of a multi-center compassionate use trial
    • Jeha, S., Kantarjian, H., Irwin, D., Shen, V., Shenoy, S., Blaney, S., Camitta, B., and Pui, C. H., Efficacy and safety of rasburicase, a recombinant urate oxidase (Elitek), in the management of malignancy-associated hyperuricemia in pediatric and adult patients: final results of a multi-center compassionate use trial. Leukemia, 19, 34-38 (2005).
    • (2005) Leukemia , vol.19 , pp. 34-38
    • Jeha, S.1    Kantarjian, H.2    Irwin, D.3    Shen, V.4    Shenoy, S.5    Blaney, S.6    Camitta, B.7    Pui, C.H.8
  • 22
    • 0014519491 scopus 로고
    • Uricase inhi-bition in the rat by s-triazines: An animal model for hyper-uricemia and hyperuricosuria
    • Johnson, W. J., Stavric, B., and Chartrand, A., Uricase inhi-bition in the rat by s-triazines: an animal model for hyper-uricemia and hyperuricosuria. Proc. Soc Exp. Biol. Med., 131, 8-12 (1969).
    • (1969) Proc. Soc Exp. Biol. Med. , vol.131 , pp. 8-12
    • Johnson, W.J.1    Stavric, B.2    Chartrand, A.3
  • 23
    • 12344260958 scopus 로고    scopus 로고
    • Uric acid and chronic renal disease: Possible implication of hyperuricemia on progres-sion of renal disease
    • Kang, D. H. and Nakagawa, T., Uric acid and chronic renal disease: possible implication of hyperuricemia on progres-sion of renal disease. Semin. Nephrol., 25, 43-49 (2005).
    • (2005) Semin. Nephrol. , vol.25 , pp. 43-49
    • Kang, D.H.1    Nakagawa, T.2
  • 25
    • 33845584080 scopus 로고    scopus 로고
    • Report of two cases of rasburicase-induced methemoglobinemia
    • Kizer, N., Martinez, E., and Powell, M., Report of two cases of rasburicase-induced methemoglobinemia. Leuk. Lymphoma, 47, 2648-2650 (2006).
    • (2006) Leuk. Lymphoma , vol.47 , pp. 2648-2650
    • Kizer, N.1    Martinez, E.2    Powell, M.3
  • 26
    • 0030225292 scopus 로고    scopus 로고
    • Novel method for coupling of poly (ethylene glycol) to carboxylic acid moieties of proteins
    • Kynclova, E., Elsner, E., Kopf, A., Hawa, G., Schalkhammer, T., and Pittner, F., Novel method for coupling of poly (ethylene glycol) to carboxylic acid moieties of proteins. J. Mol. Recognit., 9, 644-651 (1996).
    • (1996) J. Mol. Recognit. , vol.9 , pp. 644-651
    • Kynclova, E.1    Elsner, E.2    Kopf, A.3    Hawa, G.4    Schalkhammer, T.5    Pittner, F.6
  • 27
    • 0035162312 scopus 로고    scopus 로고
    • Assay of serum arylesterase activity by fitting to the reaction curve with an integrated rate equation
    • Liao, F., Liu, W. L., Zhou, Q. X., Zeng, Z. C, and Zuo, Y. P., Assay of serum arylesterase activity by fitting to the reaction curve with an integrated rate equation. Clin. Chim. Acta, 314, 67-76 (2001).
    • (2001) Clin. Chim. Acta , vol.314 , pp. 67-76
    • Liao, F.1    Liu, W.L.2    Zhou, Q.X.3    Zeng, Z.C.4    Zuo, Y.P.5
  • 28
    • 12344320206 scopus 로고    scopus 로고
    • The compar-ison on the estimation of kinetic parameters by fitting enzyme reaction curve to the integrated rate equation of different predictor variables
    • Liao, F., Zhu, X. Y., Wang, Y. M., and Zuo, Y. P., The compar-ison on the estimation of kinetic parameters by fitting enzyme reaction curve to the integrated rate equation of different predictor variables. J. Biochem. Biophys. Methods, 62, 13-24 (2005).
    • (2005) J. Biochem. Biophys. Methods , vol.62 , pp. 13-24
    • Liao, F.1    Zhu, X.Y.2    Wang, Y.M.3    Zuo, Y.P.4
  • 29
    • 33745948200 scopus 로고    scopus 로고
    • Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method
    • Liao, F., Zhao, Y. S., Zhao, L. N., Tao, J., Zhu, X. Y, and Liu, L., Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method. J. Zhejiang Univ. Sci. B, 7, 497-502 (2006).
    • (2006) J. Zhejiang Univ. Sci. B , vol.7 , pp. 497-502
    • Liao, F.1    Zhao, Y.S.2    Zhao, L.N.3    Tao, J.4    Zhu, X.Y.5    Liu, L.6
  • 30
    • 67349225643 scopus 로고    scopus 로고
    • The mea-surement of serum cholinesterase activities by an integra-tion strategy with expanded linear ranges and negligible substrate-activation
    • Liao, F., Yang, D. Y., Tang, J. Q., Yang, X. L., Liu, B. Z., Zhao, Y. S., Zhao, L. N., Liao, H., and Yu, M. A, The mea-surement of serum cholinesterase activities by an integra-tion strategy with expanded linear ranges and negligible substrate-activation. Clin. Biochem., 42, 926-928 (2009).
    • (2009) Clin. Biochem. , vol.42 , pp. 926-928
    • Liao, F.1    Yang, D.Y.2    Tang, J.Q.3    Yang, X.L.4    Liu, B.Z.5    Zhao, Y.S.6    Zhao, L.N.7    Liao, H.8    Yu, M.A.9
  • 32
    • 58149097192 scopus 로고    scopus 로고
    • Strengthening intersubunit hydrogen bonds for enhanced stability of re-combinant urate oxidase from Aspergillus flavus: Mole-cular simulations and experimental validation
    • Liu, Z., Lu, D., Li, J., Chen, W., and Liu, Z., Strengthening intersubunit hydrogen bonds for enhanced stability of re-combinant urate oxidase from Aspergillus flavus: mole-cular simulations and experimental validation. Phys. Chem. Chem. Phys., 11, 333-340 (2009b).
    • (2009) Phys. Chem. Chem. Phys. , vol.11 , pp. 333-340
    • Liu, Z.1    Lu, D.2    Li, J.3    Chen, W.4    Liu, Z.5
  • 33
    • 56049126638 scopus 로고    scopus 로고
    • Uric acid: Bystander or culprit in hypertension and progressive renal disease?
    • Mene, P. and Punzo, G., Uric acid: bystander or culprit in hypertension and progressive renal disease? J. Hypertens., 26, 2085-2092 (2008).
    • (2008) J. Hypertens. , vol.26 , pp. 2085-2092
    • Mene, P.1    Punzo, G.2
  • 34
    • 28744453997 scopus 로고    scopus 로고
    • Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats
    • Nguyen, M. T., Awale, S., Tezuka, Y, Shi, L., Zaidi, S. F., Ueda, J. Y, Tran, Q. L., Murakami, Y., Matsumoto, K., and Kadota, S., Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats. Biol. Pharm. Bull., 28, 2231-2234 (2005).
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 2231-2234
    • Nguyen, M.T.1    Awale, S.2    Tezuka, Y.3    Shi, L.4    Zaidi, S.F.5    Ueda, J.Y.6    Tran, Q.L.7    Murakami, Y.8    Matsumoto, K.9    Kadota, S.10
  • 35
    • 33646580070 scopus 로고    scopus 로고
    • Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes
    • Ramazzina, I., Folli, C, Secchi, A., Berni, R., and Percudani, R., Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nat. Chem. Biol., 2, 144-148 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 144-148
    • Ramazzina, I.1    Folli, C.2    Secchi, A.3    Berni, R.4    Percudani, R.5
  • 36
    • 0017342631 scopus 로고
    • Inhibition of uricase by substituted pyrimidines
    • Sedor, F. A. and Sander, E. G., Inhibition of uricase by substituted pyrimidines. Biochem. Biophys. Res. Commun., 75, 406-413 (1977).
    • (1977) Biochem. Biophys. Res. Commun. , vol.75 , pp. 406-413
    • Sedor, F.A.1    Sander, E.G.2
  • 37
    • 36549089052 scopus 로고    scopus 로고
    • PEG-uricase in the management of treatment-resistant gout and hyperuricemia
    • Sherman, M. R., Saifer, M. G. P., and Perez-Ruiz, F., PEG-uricase in the management of treatment-resistant gout and hyperuricemia. Adv. Drug Deliv. Rev., 60, 59-68 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 59-68
    • Sherman, M.R.1    Saifer, M.G.P.2    Perez-Ruiz, F.3
  • 38
    • 0018249234 scopus 로고
    • Use of the uricase-inhibited rat as an animal model in toxicology
    • Stavric, B. and Nera, E. A., Use of the uricase-inhibited rat as an animal model in toxicology. Clin. Toxicol., 13, 47-74 (1978).
    • (1978) Clin. Toxicol. , vol.13 , pp. 47-74
    • Stavric, B.1    Nera, E.A.2
  • 39
    • 34250727437 scopus 로고    scopus 로고
    • Uricase and other novel agents for the management of patients with treatment-failure gout
    • Sundy, J. S. and Hershfield, M. S., Uricase and other novel agents for the management of patients with treatment-failure gout. Curr. Rheumatol. Rep., 9, 258-264 (2007).
    • (2007) Curr. Rheumatol. Rep. , vol.9 , pp. 258-264
    • Sundy, J.S.1    Hershfield, M.S.2
  • 40
    • 33947119693 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombi-nant mammalian urate oxidase in patients with refrac-tory gout
    • Sundy, J. S., Ganson, N. J., Kelly, S. J., Scarlett, E. L., Rehrig, C. D., Huang, W., and Hershfield, M. S., Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombi-nant mammalian urate oxidase in patients with refrac-tory gout. Arthritis Rheum., 56, 1021-1028 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 1021-1028
    • Sundy, J.S.1    Ganson, N.J.2    Kelly, S.J.3    Scarlett, E.L.4    Rehrig, C.D.5    Huang, W.6    Hershfield, M.S.7
  • 43
    • 44049086016 scopus 로고    scopus 로고
    • Population pharmacokinetic and pharmacodynamic analysis of pegloticase in subjects with hyperuricemia and treatment-failure gout
    • Yue, C. S., Huang, W, Alton, M., Maroli, A. N., Waltrip, R. W., Wright, D., and Marco, M. D., Population pharmacokinetic and pharmacodynamic analysis of pegloticase in subjects with hyperuricemia and treatment-failure gout. J. Clin. Pharmacol., 48, 708-718 (2008).
    • (2008) J. Clin. Pharmacol. , vol.48 , pp. 708-718
    • Yue, C.S.1    Huang, W.2    Alton, M.3    Maroli, A.N.4    Waltrip, R.W.5    Wright, D.6    Marco, M.D.7
  • 44
    • 77953979420 scopus 로고    scopus 로고
    • Effects of modifica tion of amino groups with poly(Ethylene Glycol) on a recombinant uricase from Bacillus fastidiosus
    • Zhang, C, Yang, X. L, Feng, J, Yuan, Y. H, Li, X, Bu Y. Q-Xie, Y. L., Yuan, H. D., and Liao, F., Effects of modifica tion of amino groups with poly(Ethylene Glycol) on a recombinant uricase from Bacillus fastidiosus. Biosci. Biotechnol. Biochem., 74, 1298-1301 (2010).
    • (2010) Biosci. Biotechnol. Biochem. , vol.74 , pp. 1298-1301
    • Zhang, C.1    Yang, X.L.2    Feng, J.3    Yuan, Y.H.4    Li, X.5    Bu, Y.6    Q-Xie, Y.L.7    Yuan, H.D.8    Liao, F.9
  • 45
    • 33748515462 scopus 로고    scopus 로고
    • Characterization of a uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method
    • Zhao, Y. S., Zhao, L. N., Yang, G. Q., Tao, J., Bu, Y. Q., and Liao, F., Characterization of a uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method. Biotechnol. Appl. Biochem., 45, 75-80 (2006).
    • (2006) Biotechnol. Appl. Biochem. , vol.45 , pp. 75-80
    • Zhao, Y.S.1    Zhao, L.N.2    Yang, G.Q.3    Tao, J.4    Bu, Y.Q.5    Liao, F.6
  • 46
    • 70349687377 scopus 로고    scopus 로고
    • Reversible inactivation of an intracellular uri-case from Bacillus fastidiosus via dissociation of homo-tetramer into homodimers in solutions of low ionic strength
    • Zhao, Y S, Yang, X. L, Li, X. Y, Bu, Y. Q., Deng, P, Zhang, C, Feng, J, Xie, Y. L, Zhu, S., Yuan, H. D, Yu, M. A., and Liao, F., Reversible inactivation of an intracellular uri-case from Bacillus fastidiosus via dissociation of homo-tetramer into homodimers in solutions of low ionic strength. Biosci. Biotechnol. Biochem., 73, 2141-2144 (2009a).
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 2141-2144
    • Zhao, Y.S.1    Yang, X.L.2    Li, X.Y.3    Bu, Y.Q.4    Deng, P.5    Zhang, C.6    Feng, J.7    Xie, Y.L.8    Zhu, S.9    Yuan, H.D.10    Yu, M.A.11    Liao, F.12
  • 47
    • 58149472199 scopus 로고    scopus 로고
    • Uri-case based method for determination of uric acid in serum
    • Zhao, Y. S, Yang, X. Y, Lu, W, Liao, H, and Liao, F, Uri-case based method for determination of uric acid in serum. Michrochim. Acta, 164, 1-6 (2009b).
    • (2009) Michrochim. Acta , vol.164 , pp. 1-6
    • Zhao, Y.S.1    Yang, X.Y.2    Lu, W.3    Liao, H.4    Liao, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.