Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats

BMC Neuroscience

Volumn 12, Issue , 2011, Pages

  Tsuda, Yoshifumi ^a,c   Kanje, Martin ^b   Dahlin, Lars B ^c  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOREACTIVITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE REGENERATION; NEUROFILAMENT; NONHUMAN; PROTEIN EXPRESSION; RAT; SCHWANN CELL; SCIATIC NERVE; ANIMAL; COMPARATIVE STUDY; ENZYMOLOGY; METABOLISM; NERVE FIBER; PATHOLOGY; PHYSIOLOGY; SCIATIC NEUROPATHY; WISTAR RAT;

ANIMALS; AXONS; CASPASE 3; CELL DEATH; ENZYME ACTIVATION; FEMALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NERVE REGENERATION; RATS; RATS, WISTAR; SCHWANN CELLS; SCIATIC NEUROPATHY;

EID: 78651573487     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-12-12     Document Type: Article

References (26)

1. Saito H, Dahlin LB. Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair. BMC Neurosci 2008, 9:88. 10.1186/1471-2202-9-88, 2556676, 18801180.
2. Jivan S, Kumar N, Wiberg M, Kay S. The influence of pre-surgical delay on functional outcome after reconstruction of brachial plexus injuries. J Plast Reconstr Aesthet Surg 2009, 62:472-479. 10.1016/j.bjps.2007.11.027, 18485850.
3. Ruijs AC, Jaquet JB, Kalmijn S, Giele H, Hovius SE. Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast Reconstr Surg 2005, 116:484-494. discussion 495-486., 10.1097/01.prs.0000172896.86594.07, 16079678.
4. Chen ZL, Yu WM, Strickland S. Peripheral regeneration. Annu Rev Neurosci 2007, 30:209-233. 10.1146/annurev.neuro.30.051606.094337, 17341159.
5. Stoll G, Muller HW. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol 1999, 9:313-325. 10.1111/j.1750-3639.1999.tb00229.x, 10219748.
6. Sulaiman OA, Gordon T. Role of chronic Schwann cell denervation in poor functional recovery after nerve injuries and experimental strategies to combat it. Neurosurgery 2009, 65:105-114.
7. Martensson L, Gustavsson P, Dahlin LB, Kanje M. Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation. Neuroreport 2007, 18:957-961. 10.1097/WNR.0b013e32819f8f27, 17558277.
8. Saito H, Kanje M, Dahlin LB. Delayed nerve repair increases number of caspase 3 stained Schwann cells. Neurosci Lett 2009, 456:30-33. 10.1016/j.neulet.2009.03.075, 19429128.
9. Akassoglou K, Yu WM, Akpinar P, Strickland S. Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron 2002, 33:861-875. 10.1016/S0896-6273(02)00617-7, 11906694.
10. Triolo D, Dina G, Lorenzetti I, Malaguti M, Morana P, Del Carro U, Comi G, Messing A, Quattrini A, Previtali SC. Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci 2006, 119:3981-3993. 10.1242/jcs.03168, 16988027.
11. Agthong S, Kaewsema A, Tanomsridejchai N, Chentanez V. Activation of MAPK ERK in peripheral nerve after injury. BMC Neurosci 2006, 7:45. 10.1186/1471-2202-7-45, 1501035, 16762058.
12. Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC. The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 2004, 23:3061-3071. 10.1038/sj.emboj.7600309, 514926, 15241478.
13. Wiklund P, Ekstrom PA, Edstrom A. Mitogen-activated protein kinase inhibition reveals differences in signalling pathways activated by neurotrophin-3 and other growth-stimulating conditions of adult mouse dorsal root ganglia neurons. J Neurosci Res 2002, 67:62-68. 10.1002/jnr.10073, 11754081.
14. Liu RY, Snider WD. Different signaling pathways mediate regenerative versus developmental sensory axon growth. J Neurosci 2001, 21:RC164.
15. Sheu JY, Kulhanek DJ, Eckenstein FP. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 2000, 166:392-402. 10.1006/exnr.2000.7508, 11085904.
16. Yang DP, Zhang DP, Mak KS, Bonder DE, Pomeroy SL, Kim HA. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci 2008, 38:80-88. 10.1016/j.mcn.2008.01.017, 2440648, 18374600.
17. Nakao J, Shinoda J, Nakai Y, Murase S, Uyemura K. Apoptosis regulates the number of Schwann cells at the premyelinating stage. J Neurochem 1997, 68:1853-1862. 10.1046/j.1471-4159.1997.68051853.x, 9109510.
18. Iida H, Schmeichel AM, Wang Y, Schmelzer JD, Low PA. Schwann cell is a target in ischemia-reperfusion injury to peripheral nerve. Muscle Nerve 2004, 30:761-766. 10.1002/mus.20159, 15468335.
19. Gupta R, Steward O. Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J Comp Neurol 2003, 461:174-186. 10.1002/cne.10692, 12724836.
20. Krajewska M, Wang HG, Krajewski S, Zapata JM, Shabaik A, Gascoyne R, Reed JC. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res 1997, 57:1605-1613.
21. Ekström PA. Neurones and glial cells of the mouse sciatic nerve undergo apoptosis after injury in vivo and in vitro. Neuroreport 1995, 6:1029-1032.
22. Sjöberg J, Kanje M, Edström A. Influence of non-neuronal cells on regeneration of the rat sciatic nerve. Brain Res 1988, 453:221-226.
23. Sjoberg J, Kanje M. Effects of repetitive conditioning crush lesions on regeneration of the rat sciatic nerve. Brain Res 1990, 530:167-169. 10.1016/0006-8993(90)90676-3, 2271948.
24. Yamazaki T, Sabit H, Oya T, Ishii Y, Hamashima T, Tokunaga A, Ishizawa S, Jie S, Kurashige Y, Matsushima T, et al. Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves. J Peripher Nerv Syst 2009, 14:165-176. 10.1111/j.1529-8027.2009.00228.x, 19909480.
25. Sjöberg J, Kanje M. The initial period of peripheral nerve regeneration and the importance of the local environment for the conditioning effect. Brain Res 1990, 529:79-84.
26. Kerns JM, Danielsen N, Holmquist B, Kanje M, Lundborg G. The influence of predegeneration on regeneration through peripheral nerve grafts in the rat. Exp Neurol 1993, 122:28-36. 10.1006/exnr.1993.1104, 8339787.