Hepatocyte proliferation and risk of hepatocellular carcinoma in cirrhotic patients

American Journal of Gastroenterology

Volumn 96, Issue 5, 2001, Pages 1575-1580

  Sangiovanni, Angelo ^a   Colombo, Edoardo ^b   Radaelli, Franco ^a   Bortoli, Aurora ^c   Bovo, Giorgio ^d   Casiraghi, Maria Antonietta ^e   Ceriani, Roberto ^f   Roffi, Luigi ^g   Redaelli, Alessandro ^g   Rossini, Angelo ^h   Spinzi, Giancarlo ^a   Minoli, Giorgio ^a  

^a Division of Medicine   (Italy)

^b VALDUCE HOSPITAL   (Italy)

^c RHO HOSPITAL   (Italy)

^d SAN GERARDO HOSPITAL   (Italy)

^e Legnano Hospital   (Italy)

^f Ospedale G Fornaroli   (Italy)

^g UNIVERSITY OF MILAN   (Italy)

^h SPEDALI CIVILI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN;

ADULT; AGED; ARTICLE; CANCER RISK; CELL CYCLE S PHASE; CELL PROLIFERATION; CLINICAL FEATURE; DEMOGRAPHY; ECHOGRAPHY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HUMAN; ITALY; LIVER BIOPSY; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RISK FACTOR;

EID: 0034998728     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(01)02343-7     Document Type: Article

References (37)

1. Colombo M. Early diagnosis of hepatocellular carcinoma in Italy. A summary of a Consensus Development Conference held in Milan, 16 November 1990 by the Italian Association for the study of the Liver (AISF). J Hepatol. 14:1992;401-403.
2. Colombo M., De Franchis R., Del Ninno E., et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med. 325:1991;675-680.
3. Collier J., Sherman M. Screening for hepatocellular carcinoma. Hepatology. 27:1998;273-278.
4. Shibata M., Morizane T., Uchida T., et al. Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis-C-virus infection. Lancet. 351:1998;1773-1777.
5. Tarao K., Shimizu A., Harada M., et al. Difference in the in vitro uptake of bromodeoxyuridine between liver cirrhosis with and without hepatocellular carcinoma. Cancer. 64:1989;104-109.
6. Tarao K., Shimizu A., Ohkawa S., et al. Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology. 103:1992;595-600.
7. Tarao K., Ohkawa S., Shimizu A., et al. Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C virus-positive cirrhotic patients. Cancer. 73:1994;1149-1154.
8. Borzio M., Trerè D., Borzio F., et al. Hepatocyte proliferation rate is a powerful parameter for predicting hepatocellular carcinoma development in liver cirrhosis. Mol Pathol. 51:1998;96-101.
9. Derenzini M., Trerè D., Oliveri F., et al. Is high AgNOR quantity in hepatocytes associated with increased risk of hepatocellular carcinoma in chronic liver disease? J Clin Pathol. 46:1993;727-729.
10. Ballardini O., Groff P., Zoli M., et al. Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation. J Hepatol. 20:1994;218-222.
11. Ruà S., Comino A., Fruttero A., et al. Flow cytometric DNA analysis of cirrhotic liver cells in patients with hepatocellular carcinoma can provide a new prognostic factor. Cancer. 78:1996;1195-1202.
12. Bauer K.D., Bagwell C., Giaretti W., et al. Consensus review of the clinical utility of DNA flow cytometry in colorectal cancer. Cytometry. 14:1993;486-491.
13. Duque R., Andreef M., Braylan R.C., et al. Consensus review of the clinical utility of DNA flow cytometry in neoplastic hemopathology. Cytometry. 1993;492-496.
14. Hedley D.W., Clark G.M., Cornelisse C.J., et al. Consensus review of the clinical utility of DNA flow cytometry in carcinoma of the breast. Cytometry. 1993;482-485.
15. Elavathil L.J., Celebre G., McFarlane D. Reproducibility of DNA ploidy and S-phase values from paraffin-embedded tissue. Anal Quant Cytol Histol. 18:1996;316-322.
16. Bauer K.D. Quality control issues in DNA content flow cytometry. Ann NY Acad Sci. 677:1993;59-77.
17. Klemi P.J., Joensuu H. Comparison of DNA ploidy in routine fine needle aspiration biopsy samples and paraffin-embedded tissue samples. Anal Quant Cytol Histol. 10:1988;195-199.
18. Weaver D.L., Bagwell C.B., Hitchcox S.A., et al. Improved flow cytometric determination of proliferative activity (S-phase fraction) from paraffin-embedded tissue. Am J Clin Pathol. 94:1990;576-584.
19. Pugh R.N., Murray-Lyon I.M., Dawson J.L., et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 60:1973;646-649.
20. Ishak K., Baptista A., Bianchi L., et al. Histological grading and staging of chronic hepatitis. J Hepatol. 22:1995;696-699.
21. Anthony P.P., Vogel C.L., Barker L.F. Liver cell dysplasia A pregmalignant condition . J Clin Pathol. 26:1973;217-223.
22. Roncalli M., Borzio M., De Biagi G., et al. Liver cell dysplasia in cirrhosis A serologic and immunohistochemical study . Cancer. 57:1986;1515-1521.
23. Roncalli M., Borzio M., Tombesi M.V., et al. A morphometric study of liver cell dysplasia. Hum Pathol. 19:1988;471-474.
24. Terminology of nodular hepatocellular lesions. Hepatology. 22:1995;983-993.
25. Hadley D.W. Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry. J Cytochem. 31:1983;1333-1335.
26. Hedley D.W. Flow cytometry using paraffin embedded tissue Five years on . Cytometry. 10:1989;229-241.
27. Shankey T.V., Rabinovitch P.S., Bagwell B., et al. Guidelines for implementation of clinical DNA cytometry. Cytometry. 14:1993;472-477.
28. Huang S.N., Chisari F.V. Strong sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology. 21:1995;620-626.
29. Craddock V., Frei J.V. Induction of liver cell adenomata in the rat by a single treatment N-methyl-N-nitrosurea given at various times after partial hepatectomy. Br J Cancer. 30:1974;503-511.
30. Farber E. Response of the liver to carcinogenesis. Farber E., Fisher M. Injury of the liver. Part A. 1979;445-446 Marcel Dekker, New York.
31. Trerè D., Derenzini M., Sirri V., et al. Qualitative and quantitative analysis of AgNORs proteins in chemically-induced rat liver carcinogenesis. Hepatology. 24:1996;1269-1273.
32. Zhao M., Zhang N.X., Du Z.Y., et al. Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma. Histol Histopathol. 9:1994;73-83.
33. Le Bail B., Belleannee G., Bernard P.H., et al. Adenomatous hyperplasia in cirrhotic livers Histological evaluation, cellular density and proliferative activity of 35 macronodular lesions in the cirrhotic explants of 10 adult French patients . Hum Pathol. 26:1995;897-906.
34. Lee R.G., Tsamandas A.C., Demetris A.J. Large cell changes (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis Matched case-control study pathologic analysis and pathogenetic hypotesis . Hepatology. 26:1997;1415-1422.
35. Borzio M., Roncalli M., Trerè D., et al. Preneoplastic cellular changes in liver. Hepatology. 28:1998;1435-1436.
36. Borzio M., Bruno S., Roncalli M., et al. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis A prospective study . Gastroenterology. 18:1995;812-817.
37. Tsukuma H., Hiyama T., Tanaka S., et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med. 328:1993;1797-1801.