Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: Usefulness of a combined clinical and electrophysiologic approach

European Heart Journal

Volumn 32, Issue 2, 2011, Pages 169-176

  Delise, Pietro ^a   Allocca, Giuseppe ^a   Marras, Elena ^a   Giustetto, Carla ^b   Gaita, Fiorenzo ^b   Sciarra, Luigi ^c   Calo, Leonardo ^c   Proclemer, Alessandro ^d   Marziali, Marta ^c   Rebellato, Luca ^d   Berton, Giuseppe ^a   Coro, Leonardo ^a   Sitta, Nadir ^a  

^a Department of Cardiology   (Italy)

^b CARDINAL MASSAIA HOSPITAL   (Italy)

^c Casilino Policlinic ^*  (Italy)

^d SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

Author keywords

Brugada syndrome; Programmed ventricular stimulation; Risk stratification; Sudden cardiac death

Indexed keywords

ADULT; ARTICLE; BRUGADA SYNDROME; CARDIOVASCULAR RISK; ELECTROCARDIOGRAPHY; FAMILY HISTORY; FEMALE; HEART ARREST; HEART ELECTROPHYSIOLOGY; HEART VENTRICLE FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESUSCITATION; SUDDEN DEATH; SYNCOPE;

ADULT; BRUGADA SYNDROME; DEATH, SUDDEN, CARDIAC; DEFIBRILLATORS, IMPLANTABLE; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HEART ARREST; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PEDIGREE; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SYNCOPE; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION;

EID: 78651508576     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq381     Document Type: Article

References (27)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST-segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391-1396.
2. Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3. A marker for sudden death in patients without demonstrable structural heart disease. Circulation 1998;97: 457-460.
3. Proclemer A, Facchin D, Feruglio A, Nucifora R. Fibrillazione ventricolare recidivante, blocco di branca destra, persistente sopraslivellamento del tratto ST in V1-V3: una nuova sindrome aritmica? G Ital Cardiol 1993;23: 1211-1218.
4. Martini B, Nava A, Thiene G, Buja GF, Canciani B, Scognamiglio R, Daliento L, Dalla Volta S. Ventricular fibrillation without apparent heart disease: description of six cases. Am Heart J 1989;118:1203-1209.
5. Corrado D, Basso C, Buja G, Nava A, Rossi L, Thiene G. Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people. Circulation 2001;103:710.
6. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, Towbin JA. Proposed diagnostic criteria for the Brugada syndrome. Consensus report. Circulation 2002; 106:2514-2519. (Pubitemid 35278811)
7. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, Towbin JA. Proposed diagnostic criteria for the Brugada syndrome. Study Group on the Molecular Basis of Arrhythmias of the European Society of Cardiology. Eur Heart J 2002;23: 1648-1654.
8. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A. Brugada sindrome. Report of the second consensus conference. Circulation 2005;111:659-670. (Pubitemid 40216496)
9. Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR. The Brugada sindrome: clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol 1999; 33:5-15.
10. Brugada P, Benito B, Brugada R, Brugada J. Brugada syndrome: update 2009. Hellenic J Cardiol 2009;50:352-372.
11. Fowler SJ, Priori SG. Clinical spectrum of patients with a Brugada ECG. Curr Opin Cardiol. 2008;24:74-81.
12. Zipes DP, Camm JA, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, Blanc JJ, Budaj A, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL, Smith SC, Jacobs AK, Adams CD, Antman EM, Anderson JL, Hunt SA, Halperin JL, Nishimura R, Ornato JP, Page RL, Riegel B. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhytmias and the prevention of sudden cardiac death. A report of the American College of Cardiology/American Heart Association Task Force and the Europe Society of Cardiology Committee for Practice Guidelines developed in collaboration with European Heart Rhythm Association and The Heart Rhythm Society. Europace 2006;8:746-837.
13. Brugada J, Brugada R, Brugada P. Determinants of sudden death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation 2003;108:3092-3096.
14. Brugada P, Brugada R, Mont L, Rivero M, Geelen P, Brugada J. Natural history of Brugada sindrome: the prognostic value of programmed electrical stimulation of the heart. J Cardiovasc Electrophysiol 2003;14:455-457.
15. Priori SG, Napolitano C, Gasparini M, Pappone C, Della Bella P, Giordano U, Bloise R, Giustetto C, De Nardis R, Grillo M, Ronchetti E, Faggiano G, Nastoli J. Natural history of Brugada sindrome. Insight for risk stratification and management. Circulation 2002;105:1342-1347. (Pubitemid 34260426)
16. Eckardt L, Probst V, Smits JP, Bahr ES, Wolpert C, Schimpf R, Wichter T, Boisseau P, Heinecke A, Breithardt G, Borggrefe M, LeMarec H, Böcker D, Wilde AA. Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation 2005;111:257-263.
17. Brugada P, Brugada R, Brugada J, Priori S-G, Napolitano C. Should patients with an asymptomatic Brugada electrocardiogram undergo pharmacological and electrophysiological testing? Circulation 2005;112:279-292.
18. Giustetto C, Drago S, Demarchi PG, Dalmasso P, Bianchi F, Masi AS, Carvalho P, Occhetta E, Rossetti G, Riccardi R, Bertona R, Gaita F. Risk stratification of the patients with Brugada type electrocardiogram: a community-based prospective study. Europace 2009;11:507-513.
19. Probst V, Veltmann C, Eckardt L, Meregalli PG, Gaita F, Tan HL, Babuty D, Sacher F, Giustetto C, Schulze-Bahr E, Borggrefe M, Haissaguerre M, Mabo P, Le Marec H, Wolpert C, Wilde AA. Long-term prognosis of patients diagnosed with Brugada syndrome. Results from the FINGER Brugada Syndrome Registry. Circulation 2010;121:635-643.
20. Tsuji H, Sato T, Morisaki K, Iwasaka T. Prognosis of subjects with Brugada-type electrocardiogram in a population of middle-aged Japanese diagnosed during a health examination. Am J Cardiol 2008;102:584-587.
21. Benito B, Sarkozy A, Mont L, Henkens S, Berruezo A, Tamborero D, Arzamendi D, Berne P, Brugada R, Brugada P, Brugada J. Gender differences in clinical manifestations of Brugada syndrome. J Am Coll Cardiol 2008;52: 1567-1573.
22. Sidik NP, Quay NC, Loh FC, Chen LY. Prevalence of Brugada sign and syndrome in patients presenting with arrhythmic symptoms at a Heart Rhythm Clinic in Singapore. Europace 2009;11:650-656.
23. Sarkozy A, Boussy T, Kourgiannides G, Chierchia GB, Richter S, De Potter T, Geelen P, Wellens F, Spreeuwenberg MD, Brugada P. Long-term follow up of primary prophylactic implantable cardioverter-defibrillator therapy in Brugada syndrome. Eur Heart J 2007;28:334-344.
24. Sacher F, Probst V, Iesaka Y, Jacon P, Laborderie J, Mizon-Gérard F, Mabo P, Reuter S, Lamaison D, Takahashi Y, O'Neill MD, Garrigue S, Pierre B, Jäs P, Pasquié J-L, Hocini M, Salvador-Mazenq M, Nogami A, Amiel A, Defaye P, Bordachar P, Boveda S, Maury P, Klug D, Babuty D, Hässaguerre M, Mansourati J, Clémenty J, Le Marec H. Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study. Circulation 2006;114:2317-2324.
25. Gehi AK, Duong TD, Metz LD, Gomes JA, Mehta D. Risk stratification of individuals with the Brugada electrocardiogram: a meta-analysis. J Cardiovasc Electrophysiol 2006;17:577-583.
26. Paul M, Gerss J, Schulze-Bahr E, Wichter T, Vahlhaus C, Wilde AA, Breithardt G, Eckardt L. Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data. Eur Heart J 2007;28:2126-2133.
27. Gasparini M, Priori S, Mantica M, Coltorti F, Napoletano C, Galimberti P, Bloise R, Cerotti C. Programmed electrical stimulation in Brugada sindrome: how reproducible are the results? J Cardiovasc Electrophysiol 2002;13:880-887.