Partial, selective survival of nitrergic neurons in chagasic megacolon

Histochemistry and Cell Biology

Volumn 135, Issue 1, 2011, Pages 47-57

  Jabari, Samir ^a   Da Silveira, Alexandre B M ^b   De Oliveira, Enio C ^c   Neto, Salustiano G ^c   Quint, Karl ^d   Neuhuber, Winfried ^a   Brehmer, Axel ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^c FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Acquired hypoganglionosis; Enteric nervous system; Myenteric plexus; Neurodegeneration

Indexed keywords

CHOLINE ACETYLTRANSFERASE; HU PROTEIN; NITRIC OXIDE SYNTHASE;

AGED; ARTICLE; CELL COUNT; CELL SURVIVAL; CHAGAS DISEASE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GANGLION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE INNERVATION; INTESTINE MUSCLE; MALE; MEGACOLON; MOUSE; MYENTERIC PLEXUS; NERVE FIBER; NITRERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AGED; CELL SURVIVAL; CHAGAS DISEASE; CHOLINE O-ACETYLTRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; MEGACOLON; MIDDLE AGED; NITRERGIC NEURONS;

EID: 78651473739     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-010-0774-y     Document Type: Article

References (53)

1. N Akpan K Caradonna MV Chuenkova M PereiraPerrin 2008 Chagas' disease parasite derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells Brain Res 1217 195 202 1:CAS:528:DC%2BD1cXnsFCqsLY%3D 10.1016/j.brainres.2008.03.082 18502403
2. M Beck A Schlabrakowski F Schrödl W Neuhuber A Brehmer 2009 ChAT and NOS in human myenteric neurons: co-existence and co-absence Cell Tissue Res 338 37 51 1:CAS:528:DC%2BD1MXht1GmtrrJ 10.1007/s00441-009-0852-4 19711100
3. CE Bernard SJ Gibbons PJ Gomez-Pinilla MS Lurken PF Schmalz JL Roeder D Linden RR Cima EJ Dozois DW Larson M Camilleri AR Zinsmeister MJ Pozo GA Hicks G Farrugia 2009 Effect of age on the enteric nervous system of the human colon Neurogastroenterol Motil 21 746 754 1:STN:280:DC%2BD1MvltVymsg%3D%3D 10.1111/j.1365-2982.2008.01245.x 19220755
4. A Brehmer 2006 Structure of enteric neurons Adv Anat Embryol Cell Biol 186 1 94 1:STN:280:DC%2BD28vosFyhsw%3D%3D 10.1007/3-540-32874-2-1 16909915
5. A Brehmer B Blaser G Seitz F Schrödl W Neuhuber 2004 Pattern of lipofuscin pigmentation in nitrergic and non-nitrergic, neurofilament immunoreactive myenteric neuron types of human small intestine Histochem Cell Biol 121 13 20 1:CAS:528:DC%2BD2cXot1OntQ%3D%3D 10.1007/s00418-003-0603-7 14663589
6. SJ Brookes AC Meedeniya P Jobling M Costa 1997 Orally projecting interneurones in the guinea-pig small intestine J Physiol 505 Pt 2 473 491 1:CAS:528:DyaK1cXmtFOl 10.1111/j.1469-7793.1997.473bb.x 9423187
7. J Clayton 2010 Chagas disease 101 Nature 465 S4 S5 10.1038/nature09220
8. C Cortesini F Cianchi A Infantino M Lise 1995 Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation Dig Dis Sci 40 2450 2455 1:STN:280:DyaK28%2FotlCksw%3D%3D 10.1007/BF02063253 7587830
9. JR Coura PA Vinas 2010 Chagas disease: a new worldwide challenge Nature 465 S6 S7 10.1038/nature09221
10. AB da Silveira D D'Avila Reis EC de Oliveira SG Neto AO Luquetti D Poole R Correa-Oliveira JB Furness 2007 Neurochemical coding of the enteric nervous system in chagasic patients with megacolon Dig Dis Sci 52 2877 2883 10.1007/s10620-006-9680-5 17385032
11. G De Biscop 1949 Über pathologische Veränderungen am Auerbachschen Plexus bei Megacolon Z Zellforsch Mikrosk Anat 34 141 159 10.1007/BF00343041
12. RB de Oliveira LE Troncon RO Dantas UG Menghelli 1998 Gastrointestinal manifestations of Chagas' disease Am J Gastroenterol 93 884 889 10.1111/j.1572-0241.1998.270-r.x 9647012
13. G Di Nardo C Blandizzi U Volta R Colucci V Stanghellini G Barbara M Del Tacca M Tonini R Corinaldesi R De Giorgio 2008 Review article: molecular, pathological and therapeutic features of human enteric neuropathies Aliment Pharmacol Ther 28 25 42 10.1111/j.1365-2036.2008.03707.x 18410560
14. Dogiel AS (1899) Ueber den Bau der Ganglien in den Geflechten des Darmes und der Gallenblase des Menschen und der Säugethiere. Arch Anat Physiol Anat Abt (Leipzig):130-158
15. WO Dutra CA Menezes FN Villani GC da Costa AB da Silveira D Reis KJ Gollob 2009 Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease Mem Inst Oswaldo Cruz 104 Suppl 1 208 218 1:CAS:528:DC%2BD1MXhtFegtLnF 19753476
16. JM Escribà E Ponce D Romero Ade PA Vinas A Marchiol G Bassets PP Palma MA Lima C Zuniga C Ponce 2009 Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras Mem Inst Oswaldo Cruz 104 986 991 10.1590/S0074-02762009000700008 20027465
17. DL Fabbro ML Streiger ED Arias ML Bizai M del Barco NA Amicone 2007 Trypanocide treatment among adults with chronic Chagas disease living in Santa Fe city (Argentina), over a mean follow-up of 21 years: parasitological, serological and clinical evolution Rev Soc Bras Med Trop 40 1 10 10.1590/S0037-86822007000100001 17486245
18. A Fernandez M Hontebeyrie G Said 1992 Autonomic neuropathy and immunological abnormalities in Chagas' disease Clin Auton Res 2 409 412 1:STN:280:DyaK3s7nslaisg%3D%3D 10.1007/BF01831400 1290925
19. Furness JB (2006) The enteric nervous system. Blackwell, Oxford
20. D Ganns F Schrödl W Neuhuber A Brehmer 2006 Investigation of general and cytoskeletal markers to estimate numbers and proportions of neurons in the human intestine Histol Histopathol 21 41 51 1:STN:280:DC%2BD2MrovVSltQ%3D%3D 16267786
21. JR Grider 1989 Identification of neurotransmitters regulating intestinal peristaltic reflex in humans Gastroenterology 97 1414 1419 1:CAS:528: DyaK3cXkvFantQ%3D%3D 2479588
22. M Hanani Y Fellig R Udassin HR Freund 2004 Age-related changes in the morphology of the myenteric plexus of the human colon Auton Neurosci 113 71 78 10.1016/j.autneu.2004.05.007 15296797
23. TA Heanue V Pachnis 2007 Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies Nat Rev Neurosci 8 466 479 1:CAS:528:DC%2BD2sXlsVSktLc%3D 10.1038/nrn2137 17514199
24. ER Howard 1972 Hirschsprung's disease: a review of the morphology and physiology Postgrad Med J 48 471 477 1:STN:280:DyaE3s%2FitFOnsA%3D%3D 10.1136/pgmj.48.562.471 4116711
25. L Hudson PJ Hindmarsh 1985 The relationship between autoimmunity and Chagas' disease: causal or coincidental? Curr Top Microbiol Immunol 117 167 177 1:STN:280:DyaL2M3osVSmuw%3D%3D 3928268
26. G Iantorno G Bassotti Z Kogan CM Lumi AM Cabanne S Fisogni LM Varrica CR Bilder JP Munoz B Liserre A Morelli V Villanacci 2007 The enteric nervous system in chagasic and idiopathic megacolon Am J Surg Pathol 31 460 468 10.1097/01.pas.0000213371.79300.a8 17325489
27. F Köberle 1968 Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis Adv Parasitol 6 63 116 10.1016/S0065-308X(08)60472-8 4239747
28. S Krishnamurthy MD Schuffler CA Rohrmann CE Pope 1985 Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus Gastroenterology 88 26 34 1:STN:280:DyaL2M%2Flt1Ciug%3D%3D 3964770
29. A Lin S Lourenssen RD Stanzel MG Blennerhassett 2005 Selective loss of NGF-sensitive neurons following experimental colitis Exp Neurol 191 337 343 1:CAS:528:DC%2BD2MXksFKisA%3D%3D 10.1016/j.expneurol.2004.10.003 15649490
30. CR Machado MV Gomez AB Machado 1987 Changes in choline acetyltransferase activity of rat tissues during Chagas' disease Braz J Med Biol Res 20 697 702 1:CAS:528:DyaL1cXpt1Clsg%3D%3D 3137987
31. WA Meier-Ruge E Bruder 2005 Pathology of chronic constipation in pediatric and adult coloproctology Pathobiology 72 1 102 10.1159/000082310 15902901
32. UG Meneghelli 2004 Chagasic enteropathy Rev Soc Bras Med Trop 37 252 260 10.1590/S0037-86822004000300012 15330067
33. EM Murphy D Defontgalland M Costa SJ Brookes DA Wattchow 2007 Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase Neurogastroenterol Motil 19 126 134 1:CAS:528:DC%2BD2sXhtFOqu7nI 10.1111/j.1365-2982.2006.00843.x 17244167
34. L Ny K Persson B Larsson J Chan LM Weiss M Wittner H Huang HB Tanowitz 1999 Localization and activity of nitric oxide synthases in the gastrointestinal tract of Trypanosoma cruzi-infected mice J Neuroimmunol 99 27 35 1:CAS:528:DyaK1MXmtlGqs7k%3D 10.1016/S0165-5728(99)00085-5 10496174
35. RJ Phillips EJ Kieffer TL Powley 2003 Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons Auton Neurosci 106 69 83 10.1016/S1566-0702(03)00072-9 12878075
36. RJ Phillips SL Hargrave BS Rhodes DA Zopf TL Powley 2004 Quantification of neurons in the myenteric plexus: an evaluation of putative pan-neuronal markers J Neurosci Methods 133 99 107 10.1016/j.jneumeth.2003.10.004 14757350
37. AJ Porter DA Wattchow SJ Brookes M Costa 1997 The neurochemical coding and projections of circular muscle motor neurons in the human colon Gastroenterology 113 1916 1923 1:CAS:528:DyaK2sXotFSru78%3D 10.1016/S0016- 5085(97)70011-8 9394731
38. AJ Porter DA Wattchow SJ Brookes M Costa 2002 Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon Gut 51 70 75 1:CAS:528:DC%2BD38XlslOisrc%3D 10.1136/gut.51.1.70 12077095
39. U Ribeiro AV Safatle-Ribeiro A Habr-Gama JJ Gama-Rodrigues J Sohn JC Reynolds 1998 Effect of Chagas' disease on nitric oxide-containing neurons in severely affected and unaffected intestine Dis Colon Rectum 41 1411 1417 10.1007/BF02237058 9823808
40. RM Santer 1994 Survival of the population of NADPH-diaphorase stained myenteric neurons in the small intestine of aged rats J Auton Nerv Syst 49 115 121 1:STN:280:DyaK2M7gsFCnsA%3D%3D 10.1016/0165-1838(94)90131-7 7806764
41. SA Schnell WA Staines MW Wessendorf 1999 Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue J Histochem Cytochem 47 719 730 1:CAS:528:DyaK1MXjsVyrs7o%3D 10330448
42. MD Schuffler Z Jonak 1982 Chronic idiopathic intestinal pseudo-obstruction caused by a degenerative disorder of the myenteric plexus: the use of Smith's method to define the neuropathology Gastroenterology 82 476 486 1:STN:280:DyaL38%2Fps1Wgsg%3D%3D 6172315
43. MD Schuffler TD Bird SM Sumi A Cook 1978 A familial neuronal disease presenting as intestinal pseudoobstruction Gastroenterology 75 889 898 1:STN:280:DyaE1M%2FisFClsA%3D%3D 212342
44. MD Schuffler SH Leon S Krishnamurthy 1985 Intestinal pseudoobstruction caused by a new form of visceral neuropathy: palliation by radical small bowel resection Gastroenterology 89 1152 1156 1:STN:280:DyaL28%2Fgs1Wnug%3D%3D 2412932
45. Seilhean D, De Girolami U, Gray F (2004) Basic pathology of the central nervous system. In: Gray F, De Girolami U, Poirier J (eds) Manual of basic neuropathology. Butterworth, Heinemann, PA, pp 1-20
46. Smith B (1972) The neuropathology of the alimentary tract. Edward Arnold, London
47. Stach W (1989) A revised morphological classification of neurons in the enteric nervous system. In: Singer MV, Goebell H (eds) Nerves and the gastrointestinal tract. Kluwer, Lancaster, pp 29-45
48. HB Tanowitz LV Kirchhoff D Simon SA Morris LM Weiss M Wittner 1992 Chagas' disease Clin Microbiol Rev 5 400 419 1:CAS:528:DyaK3sXht1Wrs7k%3D 1423218
49. AR Teixeira N Nitz MC Guimaro C Gomes CA Santos-Buch 2006 Chagas disease Postgrad Med J 82 788 798 1:CAS:528:DC%2BD2sXhsFyqsrs%3D 10.1136/pgmj.2006. 047357 17148699
50. N Thapar 2009 New frontiers in the treatment of Hirschsprung disease J Pediatr Gastroenterol Nutr 48 Suppl 2 S92 S94 10.1097/MPG.0b013e3181a15d62 19300137
51. DA Wattchow SJ Brookes M Costa 1995 The morphology and projections of retrogradely labeled myenteric neurons in the human intestine Gastroenterology 109 866 875 1:STN:280:DyaK2MzosF2ntA%3D%3D 10.1016/0016-5085(95)90396-8 7657116
52. DA Wattchow AJ Porter SJ Brookes M Costa 1997 The polarity of neurochemically defined myenteric neurons in the human colon Gastroenterology 113 497 506 1:CAS:528:DyaK2sXls1Wnsr0%3D 10.1053/gast.1997.v113.pm9247469 9247469
53. MM Yoshida S Krishnamurthy DA Wattchow JB Furness MD Schuffler 1988 Megacolon in myotonic dystrophy caused by a degenerative neuropathy of the myenteric plexus Gastroenterology 95 820 827 1:STN:280:DyaL1c3osVaisQ%3D%3D 2456246