Fast identification of flavonoids in the roots of Sophora flavescens by on-flow LC-NMR

Journal of Medicinal Plants Research

Volumn 4, Issue 23, 2010, Pages 2452-2459

  Kim, Su Jin ^a,b   Kim, Sang Min ^a   Kim, Min Cheol ^c   Kang, Suk Woo ^a   Um, Byung Hun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Gangneung Wonju National University   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

LC hyphenated; On flow LC NMR; Prenyl flavonoid; Sophora flavescens

Indexed keywords

FLAVONOID; KURARIDIN; KURARINONE; KUSHENOL A; KUSHENOL U; LEACHIANONE A; SOPHORAFLAVANONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYTOCHEMISTRY; PLANT ROOT; SEPARATION TECHNIQUE; SOLVENT EXTRACTION; SOPHORA; SOPHORA FLAVESCENS; STRUCTURE ANALYSIS;

FABACEAE; SOPHORA FLAVESCENS;

EID: 78651465175     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: 10.5897/jmpr10.073     Document Type: Article

References (19)

1. Andrade FD, Santos LC, Datchler M, Albert K, Vilegas W (2002). Use of on-line liquid chromatography-nuclear magnetic resonance spectroscopy for the rapid investigation of flavonoids from Sorocea bomplandii. J. Chromatogr. A 953:287-291.
2. Elipe MVS (2010). LC/NMR and LC/MS/NMR. In: Cazes J (eds) Encyclopedia of chromatography, Taylor & Francis, New York, DOI:10.1081/E-ECHR3-120045283.
3. Gülc ̧in(2005). The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int. J. Food Sci. Nutr., 56:491-499.
4. Gülçin I, Elmastas M, Aboul-Enein HY (2007). Determination of assayed by different methodologies. Phytother. Res., 21: 354-361.
5. Iinuma M, Tanaka T, Mizuno M, Shirataki Y, Yokoe I, Komatsu M, Lang FA (1990). Two flavanones in Sophora leachiano and some related structures. Phytochemistry 29:2667-2669.
6. Kang SW, Kim MC, Kim CY, Jung SH, Um BH (2008). The rapid identification of isoflavonoids from Belamcanda chinensis by LC-NMR and LC-MS. Chem. Pharm. Bull. 56:1452-1454.
7. Keifer PA, Smallcombe SH, Williams EH, Salomon KE, Mendez G, Belletire JL, Moore CD (2000). Direct-injection NMR (DI-NMR): a flow NMR technique for the analysis of combinatorial chemistry libraries. J. Comb. Chem. 2:151-171.
8. Keifer PA (2010). Chemical-shift referencing and resulution stability in methanol:water gradient LC-NMR. J. Magn. Reson. DOI:10.1016/j.jmr.2010.04.009.
9. Kim JH, Ryu YB, Kang NS, Lee BW, Heo JS, Jeong IY, Park KH (2006). Glycosidase inhibitory flavonoids from Sophora flavescens. Biol. Pharm. Bull. 29:302-305.
10. Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T (1999). Antibacterial and antiandrogen flavonoids from Sophora flavescens. J. Nat. Prod. 62:1595-1599.
11. Quan W, Lee HJ, Kim CY, Noh CW, Um BH, Oak MH, Kim KM (2008). Anti-allergic prenylated flavonoids from the roots of Sophora flavescens. Planta Med. 74:168-170.
12. Row EC, Brown SA, Stachulski AV, Lennard MS (2006). Synthesis of 8- geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. Bioorg. Med. Chem., 14:3865-3871.
13. Smallcombe SH, Patt SL, Keifer PA (1995). WET Solvent Suppression and Its Applications to LC-NMR and High-Resolution NMR Spectroscopy. J. Magn. Reson., 117:295-303.
14. Tode C, Maoka T, Sugiura M (2009). Application of LC-NMR to analysis of carotenoids in food. J. Sep. Sci., 32:3659-3663.
15. Wolfender JM, Ndjoko K, Hostettmann K (2001). The potential of LC- NMR in phytochemical analysis. Phytochem. Anal., 12:2-22.
16. Woo ER, Kwak JH, Kim HJ, Park H (1998). A new prenylated flavonol from the roots of Sophora flavescens. J. Nat. Prod., 61:1552-1554.
17. Yamahara J, Kobayashi G, Iwamoto M, Chisaka T, Fujimura H, Takaishi Y, Yoshida M, Tomimatsu T, Tamai Y (1990). Vasodilatory active principles of Sophora flavescens root. J. Ethnopharmacol., 29:79-85.
18. Yazake Y, Sasaki K, Tsurumaru Y (2009). Prenylation of aromatic compounds, a key diversification of plant secondary metabolites. Phytochemistry, 70:1739-1745.
19. Zhang L, Xu L, Xiao SS, Liao QF, Li Q, Liang J, Chen XH, Bi KS (2007). Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J. Pharmaceut. Biomed., 44:1019-1028.