Identification of novel splicing events and post-transcriptional regulation of human estrogen receptor α F isoforms

Molecular and Cellular Endocrinology

Volumn 333, Issue 1, 2011, Pages 55-61

  Kobayashi, Momoko ^a   Ishii, Hirotaka ^a   Sakuma, Yasuo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

5' Untranslated region; Alternative splicing; Estrogen receptor ; Translation efficiency

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA F; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

5' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; AGED; ALTERNATIVE SPLICING; BLOTTING, SOUTHERN; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; RNA SPLICING; RNA, MESSENGER;

EID: 78651456264     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.12.003     Document Type: Article

References (22)

1. Couse J.F., Korach K.S. Estrogen receptor null mice: what have we learned and where will they lead us?. Endocr. Rev. 1999, 20:358-417.
2. Denger S., Reid G., Kos M., Flouriot G., Parsch D., Brand H., Korach K.S., Sonntag-Buck V., Gannon F. ERα gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins. Mol. Endocrinol. 2001, 15:2064-2077.
3. Figtree G.A., McDonald D., Watkins H., Channon K.M. Truncated estrogen receptor α 46-kDa isoform in human endothelial cells: relationship to acute activation of nitric oxide synthase. Circulation 2003, 107:120-126.
4. Flouriot G., Brand H., Denger S., Metivier R., Kos M., Reid G., Sonntag-Buck V., Gannon F. Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1. EMBO J. 2000, 19:4688-4700.
5. Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., Chambon P. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A. Nature 1986, 320:134-139.
6. Hirata S., Shoda T., Kato J., Hoshi K. Isoform/variant mRNAs for sex steroid hormone receptors in humans. Trends Endocrinol. Metab. 2003, 14:124-129.
7. Ishii H., Kobayashi M., Sakuma Y. Alternative promoter usage and alternative splicing of the rat estrogen receptor α gene generate numerous mRNA variants with distinct 5'-ends. J. Steroid Biochem. Mol. Biol. 2010, 118:59-69.
8. Keaveney M., Parker M.G., Gannon F. Identification of a functional role for the 3' region of the human oestrogen receptor gene. J. Mol. Endocrinol. 1993, 10:143-152.
9. Kenealy M.R., Flouriot G., Sonntag-Buck V., Dandekar T., Brand H., Gannon F. The 3'-untranslated region of the human estrogen receptor α gene mediates rapid messenger ribonucleic acid turnover. Endocrinology 2000, 141:2805-2813.
10. Kent W.J. BLAT-the BLAST-like alignment tool. Genome Res. 2002, 12:656-664.
11. Kos M., O'Brien S., Flouriot G., Gannon F. Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor α gene. FEBS Lett. 2000, 477:15-20.
12. Kos M., Reid G., Denger S., Gannon F. Minireview: genomic organization of the human ERα gene promoter region. Mol. Endocrinol. 2001, 15:2057-2063.
13. Kos M., Denger S., Reid G., Gannon F. Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor α. J. Biol. Chem. 2002, 277:37131-37138.
14. Leivonen S.K., Makela R., Ostling P., Kohonen P., Haapa-Paananen S., Kleivi K., Enerly E., Aakula A., Hellstrom K., Sahlberg N., Kristensen V.N., Borresen-Dale A.L., Saviranta P., Perala M., Kallioniemi O. Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 2009, 28:3926-3936.
15. Matthews J., Gustafsson J.A. Estrogen signaling: a subtle balance between ERα and ERβ. Mol. Interv. 2003, 3:281-292.
16. Murphy A.J., Guyre P.M., Wira C.R., Pioli P.A. Estradiol regulates expression of estrogen receptor ERα46 in human macrophages. PLoS One 2009, 4:e5539.
17. Li L., Haynes M.P., Bender J.R. Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:4807-4812.
18. Okuda Y., Hirata S., Watanabe N., Shoda T., Kato J., Hoshi K. Novel splicing events of untranslated first exons in human estrogen receptor alpha (ERα) gene. Endocr. J. 2003, 50:97-104.
19. Penot G., Peron C.L., Merot Y., Grimaud-Fanouillere E., Ferriere F., Boujrad N., Kah O., Saligaut C., Ducouret B., Metivier R., Flouriot G. The human estrogen receptor-α isoform hERα46 antagonizes the proliferative influence of hERα66 in MCF7 breast cancer cells. Endocrinology 2005, 146:5474-5484.
20. Sanyal A., Riggs B.L., Spelsberg T.C., Khosla S. Bone marrow stromal cells express two distinct splice variants of ER-α that are regulated by estrogen. J. Cell. Biochem. 2005, 94:88-97.
21. Smith L., Coleman L.J., Cummings M., Satheesha S., Shaw S.O., Speirs V., Hughes T.A. Expression of oestrogen receptor β isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem. J. 2010, 429:283-290.
22. Wang Z.Y., Zhang X.T., Shen P., Loggie B.W., Chang Y.G., Deuel T.F. Identification, cloning, and expression of human estrogen receptor-α36, a novel variant of human estrogen receptor-α66. Biochem. Biophys. Res. Commun. 2005, 336:1023-1027.