Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise

Journal of Physiology

Volumn 589, Issue 2, 2011, Pages 423-429

  Volianitis, S ^a   Rasmussen, P ^b   Seifert, T ^b   Nielsen, H B ^b   Secher, N H ^b  

^a AALBORG UNIVERSITY   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ADULT; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD PH; BRAIN LEVEL; CEREBRAL METABOLIC RATE OF OXYGEN; EXERCISE; EXERCISE INTENSITY; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC ACIDOSIS; MOTOR PERFORMANCE; NORMAL HUMAN; PRIORITY JOURNAL; WORK CAPACITY;

ACIDOSIS; ADULT; BRAIN; ENERGY METABOLISM; ERGOMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MALE; MUSCLE, SKELETAL; OXYGEN; PHYSICAL EXERTION;

EID: 78651423840     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.195636     Document Type: Article

References (32)

1. Bergersen LH (2007). Is lactate food for neurons? Comparisons of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145, 11-19.
2. Byrd SK, McCutcheon LJ, Hodgson DR & Gollnick PD (1989). Altered sarcoplasmic reticulum function after high-intensity exercise. J Appl Physiol 67, 2072-2077.
3. Cooper DJ, Walley KR, Dodek PM, Rosenberg F & Russell JA (1992). Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis. Intensive Care Med 18, 286-289.
4. 3. Int J Sports Med 5, 228-231.
5. 2/carbohydrate uptake ratio in humans. J Physiol 540, 681-689.
6. Fencl V, Vale JR & Broch JA (1969). Respiration and cerebral blood flow in metabolic acidosis and alkalosis in humans. J Appl Physiol 27, 67-76.
7. Gladden LB (2004). Lactate metabolism: a new paradigm for the third millennium. J Physiol 558, 5-30.
8. Holmqvist N, Secher NH, Sander-Jensen K, Knigge U, Warberg J & Schwartz TW (1986) Sympathoadrenal and parasympathetic responses to exercise. J Sport Sci 4, 123-128.
9. 2 uptake in human brain during recovery from maximal exercise. J Physiol 522, 159-164.
10. Jenstrup M, Ejlersen E, Mogensen T & Secher NH (1995). A maximal central venous oxygen saturation S for the surgical patient. Acta Anaesthesiol Scand Suppl 107, 29-32.
11. Juel C (1997). Lactate-proton cotransport in skeletal muscle. Physiol Rev 77, 321-358.
12. Lubow JM, Pinon IG, Avogaro A, Cobelli C, Treeson DM, Mandeville KA, Toffolo G & Boyle PJ (2006). Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit. Am J Physiol Endocrinol Metab 290, E149-E153.
13. Mainwood GW & Renaud JM (1985). The effect of acid-base balance on fatigue of skeletal muscle. Can J Physiol Pharmacol 63, 403-416.
14. 2 tension but attenuates desaturation of haemoglobin in maximally exercising thoroughbreds. J Appl Physiol 96, 1349-1356.
15. 2 supplementation. Am J Physiol Heart Circ Physiol 277, H1045-H1052.
16. Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B & Secher NH (2002a). Bicarbonate attenuates arterial desaturation during maximal exercise in humans. J Appl Physiol 93, 724-731.
17. Nielsen HB, Hein L, Svendsen LB, Secher NH & Quistorff B (2002b). Bicarbonate attenuates intracellular acidosis. Acta Anaesthesiol Scand 46, 579-584.
18. Oldendorf W, Braun L & Cornford E (1979). pH dependence of blood-brain barrier permeability to lactate and nicotine. Stroke 10, 577-581.
19. Orr JA, Bisgard GE, Forster HV, Buss DD, Dempsey JA & Will JA (1975). Cerebrospinal fluid alkalosis during high-altitude sojourn in unanesthetized ponies. Respir Physiol 25, 23-37.
20. Owen O, Morgan A, Kemp H, Sullivan J, Herrera M & Cahill GJ (1967). Brain metabolism during fasting. J Clin Invest 46, 1589-1595.
21. Quistorff B, Secher NH & Van Lieshout JJ (2008). Lactate fuels the human brain during exercise. FASEB J 22, 3443-3449.
22. Rivers E, Paradis N, Martin G, Goetting M, Rosenberg J, Smithline H, Appleton T & Nowak R (1991). Cerebral lactate uptake during cardiopulmonary resuscitation in humans. J Cereb Blood Flow Metab 11, 479-484.
23. Robach P, Déchaux M, Jarrot S, Vaysse J, Schneider JC, Mason NP, Herry JP, Gardette B & Richalet JP (2000). Operation Everest III: role of plasma volume expansion on during prolonged high-altitude exposure. J Appl Physiol 89, 29-37.
24. Schroeder T & Sillesen H (1987). Dihydralazine induces marked cerebral vasodilation in man. Eur J Clin Invest 17, 214-217.
25. Seifert TS, Brassard P, Jørgensen TB, Hamada AJ, Rasmussen P, Quistorff B, Secher NH & Nielsen HB (2009). Cerebral non-oxidative carbohydrate consumption in humans driven by adreanline. J Physiol 587, 285-293.
26. Spencer & Lehninger (1976), L-lactate transport in Ehrlich ascites-tumor cells. Biochem J 154, 405-414.
27. Thomas DJ, Marshall J, Russell RW, Wetherley-Mein G, du Boulay GH, Pearson TC, Symon L, Zilkha E (1977). Effect of haematocrit on cerebral blood-flow in man. Lancet 2, 941-943.
28. van Hall G (2010). Lactate kinetics in human tissues at rest and during exercise. Acta Physiol 199, 499-508.
29. van Hall G, Strømstad M, Rasmussen P, Jans O, Zaar M, Gam C, Quistorff B, Secher NH & Nielsen HB (2009). Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 29, 1121-1129.
30. Volianitis S, Fabricius-Bjerre A, Overgaard A, Strømstad M, Bjarrum M, Carlson C, Petersen NT, Rasmussen P, Secher NH & Nielsen HB (2008). The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans. J Physiol 586, 107-112.
31. Volianitis S & Secher NH (2009). Rowing, the ultimate challenge to the human body - implications for physiological variables. Clin Physiol Funct Imaging 29, 241-244.
32. 3-buffered media in cultured epithelial cells from rainbow trout gills. J Comp Physiol B 170, 175-184.