Deontological and altruistic guilt: Evidence for distinct neurobiological substrates

Human Brain Mapping

Volumn 32, Issue 2, 2011, Pages 229-239

  Basile, Barbara ^a,b   Mancini, Francesco ^b   Macaluso, Emiliano ^a   Caltagirone, Carlo ^a,c   Frackowiak, Richard S J ^a,d   Bozzali, Marco ^a,e  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b APC School of Psychotherapy   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e NONE   (Italy)

Author keywords

Altruistic; Anterior cingulate cortex; Deontological; Emotion; FMRI; Guilt

Indexed keywords

ADULT; ALTRUISM; ANGER; ARTICLE; BEHAVIOR; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; DEONTOLOGY; EMOTION; FACIAL EXPRESSION; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GUILT; HUMAN; MALE; NERVE CELL NETWORK; NEUROBIOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; REACTION TIME;

ADULT; BRAIN; BRAIN MAPPING; EMOTIONS; FACE; FEMALE; GUILT; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MORALS; NEURAL PATHWAYS; OXYGEN; PAIN MEASUREMENT; PHOTIC STIMULATION; REACTION TIME; YOUNG ADULT;

EID: 78651414839     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.21009     Document Type: Article

References (56)

1. Baumeister RF (2005): The Cultural Animal: Human Nature, Meaning, and Social Life. New York: Oxford University Press.
2. Bechara A, Damasio H, Damasio AR (2000): Emotion, decision making and the orbitofrontal cortex. Cereb Cortex 10: 295-307.
3. Blair RJ (1995): A cognitive developmental approach to morality: Investigating the psychopath. Cognition 57: 1-29.
4. Blair RJ (2004): The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn 55: 198-208.
5. Bush G, Luu P, Posner MI (2000): Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4: 215-222.
6. Damasio AR (1994): Descartes' Error: Emotion, Reason, and the Human Brain. New York: Grosset/Putnam.
7. Devinsky O, Morrell MJ, Vogt BA (1995): Contributions of anterior cingulate cortex to behaviour. Brain 118: 279-306.
8. Drevets WC, Raichle ME (1998): Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: Implications for interactions between emotion and cognition. Cognition Emotion 12: 353-385.
9. Ekman P, Friesen WV (1976): Pictures of Facial Affect. Palo Alto: Consulting Psychologists.
10. Gilbert P (1992): Depression: The Evolution of Powerlessness. Hove: Lawrence Erlbaum Associates.
11. Haidt J, Hersh MA (2001): Sexual morality: The cultures and reasons of liberals and conservatives. J Appl Soc Psychol 31: 191-221.
12. Hoffman M (1981): Is altruism a part of human nature? J Pers Soc Psychol 40: 121-137.
13. Hornak J, Bramham J, Rolls ET, Morris RG, O'Doherty J, Bullock PR (2003): Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain 126: 1691-1712.
14. Humphrey N (1997): Varieties of altruism-And the common ground between them. Social Res 64: 199-209.
15. Kédia G, Berthoz S, Wessa M, Hilton D, Martinot JL (2008): An agent harms a victim: A functional magnetic resonance imaging study on specific moral emotions. J Cogn Neurosci 20: 1788-1798.
16. Koenigs M, Young L, Adolphs R, Tranel D, Cushman F, Hauser M, Damasio A (2007): Damage to the prefrontal cortex increases utilitarian moral judgments. Nature 19: 908-911.
17. Krajbich I, Adolphs R, Tranel D, Denburg NL, Camerer CF (2009): Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex. J Neurosci 29: 2188-2192.
18. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ (1997): Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 154: 929-933.
19. Link NF, Scherer SE, Byrne PN (1977): Moral judgement and moral conduct in the psychopath. Can Psychiatr Assoc J 22: 341-346.
20. Maddock RJ (1999): The retrosplenial cortex and emotion: New insights from functional neuroimaging of the human brain. Trends Neurosci 22: 310-316.
21. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT. (1999): Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness. Am J Psychiatry 156: 675-682.
22. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005): Deep brain stimulation for treatment-resistant depression. Neuron 3: 651-660.
23. Mendez MF (2006): What frontotemporal dementia reveals about the neurobiological basis of morality. Med Hypotheses 67: 411-418.
24. Miller WI (1997): The Anatomy of Disgust. Cambridge: Harvard University Press.
25. Moll J, de Oliveira-Souza R, Moll FT, Ignácio FA, Bramati IE, Caparelli-Dáquer EM, Eslinger PJ (2005a): The moral affiliations of disgust: A functional MRI study. Cogn Behav Neurol 18: 68-78.
26. Moll J, Zahn R, de Oliveira-Souza R, Krueger F, Grafman J (2005b): Opinion: The neural basis of human moral cognition. Nat Rev Neurosci 6: 799-809.
27. Moll J, Krueger F, Zahn R, Pardini M, de Oliveira-Souza R, Grafman J (2006): Human fronto-mesolimbic networks guide decisions about charitable donation. Proc Natl Acad Sci USA 103: 15623-15628.
28. Moll J, de Oliveira-Souza R, Garrido GJ, Bramati IE, Caparelli-Daquer EM, Paiva ML, Zahn R, Grafman J (2007): The self as a moral agent: Linking the neural bases of social agency and moral sensitivity. Soc Neurosci 2: 336-352.
29. Moll J, De Oliveira-Souza R, Zahn R (2008): The neural basis of moral cognition: Sentiments, concepts, and values. Ann N Y Acad Sci 1124: 161-180.
30. Murphy NI, Lawrence AD (2003): Functional neuroanatomy of emotion: A meta-analysis. Cogn Affect Behav Neurosci 3: 207-233.
31. O'Connor LE, Berry JW, Weiss J (1999): Interpersonal guilt, shame and psychological problems. J Social Clin Psychol 18: 356-361.
32. O'Connor LE, Berry JW, Weiss J, Schweitzer D, Sevier M (2000): Survivor guilt, submissive behaviour and evolutionary theory: The down-side of winning in social comparison. Br J Med Psychol 73: 519-530.
33. O'Connor LE, Berry JW, Weiss J, Gilbert P (2002): Guilt, fear, submission, and empathy in depression. J Affec Disord 71: 19-27.
34. Pardini DA, Lochman JE, Frick PJ (2003): Callous/unemotional traits and social-cognitive processes in adjudicated youths. J Am Acad Child Adolesc Psychiatry 42: 364-371.
35. Phan KL, Wager T, Taylor SF, Liberzon I (2002): Fuctional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16: 331-348.
36. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, Calder AJ, Bullmore ET, Perrett DI, Rowland D, Williams SC, Gray JA, David AS (1997): A specific neural substrate for perceiving facial expressions of disgust. Nature 389: 495-498.
37. Phillips ML, Young AW, Scott SK, Calder AJ, Andrew C, Giampietro V, Williams SC, Bullmore ET, Brammer M, Gray JA (1998): Neural responses to facial and vocal expressions of fear and disgust. Biol Sci 265: 1809-1817.
38. Phillips ML, Drevets WC, Rauch SL, Lane R (2003): Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry 54: 504-514.
39. Posner MI, DiGirolamo GJ (1998): Executive attention: Conflict, target detection and cognitive control. In: Parasuraman R (Ed.), The Attentive Brain. Cambridge, MA: MIT Press. pp 401-423.
40. Rachman S (1993): Obsessions, responsibility and guilt. Beh Res Ther 31: 149-154.
41. Rolls ET (2005): Emotion Explained. Oxford: Oxford University Press.
42. Rolls ET, Tovee MJ, Panzeri S (1999): The neurophysiology of backward visual masking: Information analysis. J Cogn Neurosci 11: 335-346.
43. Rozin P, Haidt J, McCauley CR (2000): Disgust. In: Lewis M, Haviland-Jones J, editors. Handbook of Emotions, 2nd ed. New York: Guilford Press. pp 673-653.
44. Salkovskis P (1989): Cognitive-behavioral factors and the persistence of intrusive thought in obsessional problems. Behav Res Ther 27: 677-682.
45. Shafran R, Watkins E, Charman T (1996): Guilt in obsessive-compulsive disorder. J Anxiety Disord 10: 509-516.
46. Shallice T (2001): 'Theory of mind' and the prefrontal cortex. Brain 124: 247-248.
47. Shin LM, Dougherty DD, Orr SP, Pitman RK, Lasko M, Macklin ML, Alpert NM, Fischman AJ, Rauch SL (2000): Activation of anterior paralimbic structures during guilt-related script-driven imagery. Biol Psychiatry 48: 43-50.
48. Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD (2006): Empathic neural responses are modulated by the perceived fairness of others. Nature 26: 466-469.
49. Sinnott-Armstrong W (1996): Moral Knowledge? New York: Oxford University Press.
50. Steele JD, Lawrie SM (2004): Segregation of cognitive and emotional function in the prefrontal cortex: A stereotactic meta-analysis. Neuroimage 21: 868-875.
51. Takahashi H, Yahata N, Koeda M, Matsuda T, Asai K, Okubo Y (2004): Brain activation associated with evaluative processes of guilt and embarrassment: An fMRI study. Neuroimage 23: 967-974.
52. Vogt BA, Abscher JR, Bush G (2000): Human retrosplenial cortex: Where is it and is it involved in emotion? Trends Neurosci 23: 195-196.
53. Weiss E, O'Connell AN, Siiter R (1986): Comparisons of second-generation holocaust survivors, immigrants, and non-immigrants on measures of mental health. J Pers Soc Psychol 50: 828-531.
54. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G (2003): Both of us disgusted in my insula: The common neural basis of seeing and feeling disgust. Neuron 40: 655-664.
55. Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1996): A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 4: 58-73.
56. Zahn R, de Olivera-Souza, Bramati I, Garrido G, Moll J (2009): Subgenual cingulated activity reflects individual differences in empathic concern. Neurosci Lett 457: 107-110.