A vitamin E-coated polysulfone membrane reduces serum levels of inflammatory markers and resistance to erythropoietin-stimulating agents in hemodialysis patients: Results of a randomized cross-over multicenter trial

Blood Purification

Volumn 32, Issue 1, 2011, Pages 7-14

  Panichi, Vincenzo ^a   Rosati, Alberto ^b   Paoletti, Sabrina ^a   Ferrandello, Paolo ^a   Migliori, Massimiliano ^a   Beati, Sara ^a   Bernabini, Giada ^a   Daini, Roberto ^c   Casani, Aldo ^c   Angelini, Daniela ^b   Parrini, Manuela ^b   Rossi, Arturo ^d   Petrone, Isabella ^d   Barsotti, Giuliano ^e   Donadio, Carlo ^e   Donati, Giaclì ^f   Grazi, Giovanni ^f   Manca Rizza, Giovanni ^f   Garosi, Guido ^g   Sansoni, Enrico ^g   Braccagni, Beatrice ^g   Sidoti, Antonino ^h   Boracelli, Donella ^h   Biagioli, Marina ^h   Moriconi, Luigi ⁱ   Finato, Viviana ⁱ   Mannarino, Antonio ^j   Grimaldi, Cristina ^j   Pansa, Filomena ^k   Imperiali, Patrizio ^k   Mura, Carlo ^k   Bianchi, Stefano ^k   Bigazzi, Roberto ^l   more..

^a Hospital of Versilia   (Italy)

^b Hospital of Lucca   (Italy)

^c Massa Hosp   (Italy)

^d PISTOIA HOSPITAL   (Italy)

^e UNIVERSITY OF PISA   (Italy)

^f Department of Nephrology and Dialysis   (Italy)

^g University Hospital of Siena   (Italy)

^h Department of Nephrology and Dialysis   (Italy)

ⁱ Department of Nephrology and Dialysis   (Italy)

^j University Hospital of Florence   (Italy)

^k Hospital of Arezzo   (Italy)

^l Livorno Hospital   (Italy)

more..

Author keywords

C reactive protein; Cytokines; Erythropoiesis stimulating agent; Erythropoietin; Hemodialysis; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; BICARBONATE; C REACTIVE PROTEIN; ERYTHROPOIETIN; HEMOGLOBIN; INTERLEUKIN 6; POLYSULFONE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIALYSIS MEMBRANE; DISEASE MARKER; ENZYME IMMUNOASSAY; ERYTHROCYTE COUNT; FEMALE; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THERAPY RESISTANCE;

AGED; AGED, 80 AND OVER; ANTIOXIDANTS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; COATED MATERIALS, BIOCOMPATIBLE; CROSS-OVER STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; FEMALE; FOLLOW-UP STUDIES; HEMATINICS; HEMOGLOBINS; HUMANS; INTERLEUKIN-6; ITALY; KIDNEY FAILURE, CHRONIC; LIPID PEROXIDATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYMERS; RENAL DIALYSIS; SINGLE-BLIND METHOD; SULFONES; VITAMIN E;

EID: 78651412351     PISSN: 02535068     EISSN: 14219735     Source Type: Journal    
DOI: 10.1159/000321369     Document Type: Article

References (32)

1. Himmelfarb J, Stenvinkel P, Ikizler T, Hakim R: The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002; 62: 1524-1538. (Pubitemid 35286260)
2. Locatelli F, Canaud B, Eckardt K, Stenvinkel P, Wanner C, Zoccali C: Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant 2003; 18: 1272-1280. (Pubitemid 36826946)
3. Lazarus J, Hakim R: Reactive oxygen species production by monocytes and polymorphonuclear leukocytes during dialysis. Am J Kidney Dis 1991; 17: 271-276.
4. Himmelfarb J, Ault KA, Holbrook D, Leeber DA, Hakim RM: Intradialytic granulocyte reactive oxygen species production: a prospective, crossover trial. J Am Soc Nephrol 1993; 42: 178-186.
5. Ward R, McLeish K: Hemodialysis with cellulose membranes primes the neutrophil oxidative burst. Artif Organs 1995; 19: 801-807.
6. Steinberg D: Beyond cholesterol. Modification of low density lipoprotein that increases its atherogenicity. N Engl J Med 1989; 320: 915-924. (Pubitemid 19101597)
7. Boaz M, Smetana S, Weinstein T: Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet 2000; 356: 1213-1218.
8. Boaz M, Dotan Y, Iuliano L, Smetana S, Matas Z, Weinstein T: Vitamin E treatment benefit associated with baseline levels of oxidative stress in hemodialysis patients. J Am Soc Nephrol 2005; 16: 469A.
9. Traber MG, Atkinson J: Vitamin E, antioxidant and nothing more. Free Radic Biol Med 2007; 43: 4-15. (Pubitemid 46874839)
10. Galli F: Vitamin E-modified dialysers; in Ronco C, La Greca G (eds): Hemodialysis Technology. Contrib Nephrol. Basel, Karger, 2002, vol 137, pp 95-105.
11. Sasak M et al: Development of vitamin Emodified polysulfone membrane dialyzers. J Artif Organs 2006; 9: 50-60.
12. Floridi A, Piroddi M, Pilolli F, Matsumoto Y, Aritomi M, Galli F: Analysis method and characterization of the antioxidant capacity of vitamin E-interactive polysulfone hemodialyzers. Acta Biomater 2009; 5: 2974-2982.
13. Andrulli S, Di Filippo F, Manzoni C, Stefanelli L, Floridi A, Galli F, Locatelli F: Effect of synthetic vitamin E-bonded membrane on responsiveness to erythropoiesis-stimulating agents in hemodialysis patients: a pilot study. Nephron Clin Pract 2010; 115:c82-c89.
14. Matsamura M, Sasaki H, Sekizuka K Sano H, Ogawa K, Shimizu C, Yoshida H, Kobayashi S, Koremoto M, Aritomi M, Ueki K: Improved management of intradialytic hypotension (IDH) using vitamin E-bonded polysulfone membrane dialyzer. Int J Artif Organs, in press.
15. National Kidney Foundation: KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis 2006; 47:S11-S18.
16. Daugirdas JT, Schneditz D: Overestimation of hemodialysis dose (delta Kt/V) depends on dialysis efficiency by regional blood flow and conventional 2-pool urea kinetic analysis. ASAIO J 1995; 41:M719-M724.
17. Locatelli F, Andrulli S, Memoli B, Maffei C, Del Vecchio L, Aterini S, De Simone W, Mandalari A, Brunori G, Amato M, Cianciaruso B, Zoccali C: Nutritional-inflammation status and resistance to erythropoietin therapy in haemodialysis patients. Nephrol Dial Transplant 2006; 21: 991-998.
18. Usberti M, Gerardi G, Bufano G, Tira P, Micheli A, Albertini A, Floridi A, Di Lorenzo D, Galli F: Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients. Am J Kidney Dis 2002; 40: 590-599. (Pubitemid 34971289)
19. Nakatan T, Takemoto Y, Tsuchida AK: The effect of vitamin E-bonded dialyzer membrane on red blood cell survival in hemodialyzed patients. Artif Organs 2003; 27: 214-217. (Pubitemid 36423474)
20. Westhuyzen J, Saltissi D, Stanbury V: Oxidative stress and erythrocyte integrity in endstage renal failure patients hemodialysed using a vitamin E-modified membrane. Ann Clin Lab Sci 2003; 33: 3-10. (Pubitemid 36336993)
21. Usberti M, Gerardi G, Micheli A, Tira P, Bufano G, Gaggia P, Movilli E, Cancarini GC, De Marinis S, D'Avolio G, Broccoli R, Manganoni A, Albertin A, Di Lorenzo D: Effects of a vitamin E-bonded membrane and of glutathione on anemia and erythropoietin requirements in hemodialysis patients. J Nephrol 2002; 15: 558-564. (Pubitemid 35396521)
22. Kobayashi S, Moriya H, Aso K, Ohtake T: Vitamin E-bonded hemodialyzer improves atherosclerosis associated with a rheological improvement of circulating red blood cells. Kidney Int 2003; 63: 1881-1887. (Pubitemid 36513337)
23. Usberti M, Bufano G, Lima G, Gazzotti RM, Tira P, Gerardi G, Di Lorenzo D: Increased red blood cell survival reduces the need of erythropoietin in hemodialyzed patients treated with exogenous glutathione and vitamin E-modified membrane; in La Greca G, Ronco C (eds): E-Bonded Membranes. Contrib Nephrol. Basel, Karger,1999, vol 127, pp 208-214.
24. Taccone-Gallucci M, Meloni C, Lubrano R, Morosetti M, Palombo G, Cianciulli P, Scoppi P, Castello MA, Casciani CU: Chronic haemolysis and erythrocyte survival in haemodialysis patients treated with vitamin Emodified dialysis filters; in La Greca G, Ronco C (eds): E-Bonded Membranes. Contrib Nephrol. Basel, Karger, 1999, vol 127, pp 44-48.
25. Tsuruoka S, Kawaguchi A, Nishiki K, Hayasaka T, Fukushima C, Sugimoto K, Saito T, Fujimura A: Vitamin E-bonded hemodialyzer improves neutrophil function and oxidative stress in patients with end-stage renal failure. Am J Kidney Dis 2002; 39: 127-133. (Pubitemid 34062505)
26. Triolo L, Malaguti M, Ansali F, Comunian MC, Arcangeloni O, Coppolino F, Marrocco F, Sicoli R, Biagini M: Vitamin E-bonded cellulose membrane, lipoperoxidation, and anemia in hemodialysis patients. Artif Cells Blood Substit Immobil Biotechnol 2003; 31: 185-191. (Pubitemid 36560174)
27. Cruz DN, De Cali M, Grazotto F, Brendolan A, Nalesso F, Corradi V, Ronco C: Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: An Italian multicenter study. Int J Artif Organs 2008; 31: 545-552.
28. Morimoto H, Nakao K, Fukuoka K, Sarai A, Yano A, Kihara T, Fukuda S, Wada J, Makino H: Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients. Nephrol Dial Transplant 2005; 20: 2775-2782. (Pubitemid 41672279)
29. Locatelli F, Aljama P, Bárány P, Canaud B, Carrera F, Eckardt KU, Hörl WH, Macdougal IC, Macleod A, Wiecek A, Cameron S; European Best Practice Guidelines Working Group: Revised European Best Practice Guidelines for the Management Of Anaemia In Patients With Chronic Renal Failure. Nephrol Dial Transplant 2004; 19(suppl 2): ii1-ii47.
30. Tsai A, Berns JS: Use of erythropoietic-stimulating agents in hemodialysis patients; in Nissenson AR, Fine RN (eds): Handbook of dialysis therapy, ed 4. Philadelphia, Saunders, Elsevier, 2008, pp 771-785.
31. Cruz DN, de Cal M, Ronco C: Oxidative stress and anemia in chronic hemodialysis: the promise of bioreactive membranes; in Ronco C, Cruz DN (eds): Hemodialysis-From Basic Research to Clinical Trials. Contrib Nephrol. Basel, Karger, 2008, vol 161, pp 89-98.
32. Stenvinkel P, Bárány P: Anaemia, rHuEPO resistance, and cardiovascular disease in end-stage renal failure: links to inflammation and oxidative stress. Nephrol Dial Transplant 2002; 17(suppl 5):32-37. (Pubitemid 34823070)