Understanding risks and benefits in research on reproductive genetic technologies

Journal of Medicine and Philosophy

Volumn 32, Issue 4, 2007, Pages 339-358

  Malek, Janet ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Benefits; Genetic technology; Reproductive technology; Research; Risks

Indexed keywords

ARTICLE; CLINICAL PROTOCOL; CLONING; DEVELOPMENTAL DISORDER; ECONOMIC ASPECT; FERTILIZATION; FERTILIZATION IN VITRO; GENE TECHNOLOGY; GENETIC DISORDER; GENETIC RISK; GENETIC SELECTION; GENETIC TRAIT; GENOTYPE; HUMAN; INFERTILITY THERAPY; MEDICAL DOCUMENTATION; MEDICAL ETHICS; MEDICAL RESEARCH; MEDICOLEGAL ASPECT; PSYCHOLOGICAL ASPECT; REPRODUCTION; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SOCIAL ASPECT;

FEMALE; GENETIC RESEARCH; HUMANS; MALE; PATIENT SELECTION; REPRODUCTIVE TECHNIQUES; RISK ASSESSMENT;

EID: 34548070215     PISSN: 03605310     EISSN: 17445019     Source Type: Journal    
DOI: 10.1080/03605310701515369     Document Type: Article

References (22)

1. Al-Shawaf, T., Zosmer, A., Dirnfeld, M., & Grudzinskas, G. (2005). 'Safety of drugs used in assisted reproduction techniques,' Drug Safety, 28, 513-528.
2. Benatar, D. (1997). 'Why it is better never to come into existence,' American Philosophical Quarterly, 34, 345-55.
3. Brody, B. (2001). 'Defending animal research: an international perspective,' in Taking Issue: Pluralism and Casuistry in Bioethics, Washington, DC: Georgetown University Press.
4. Department of Health and Human Services. (2002). 'RAC will not at present entertain proposals for germ line alterations,' NIH Guidelines for Research Involving Recombinant DNA Molecules. Washington, DC: US Government Printing Office.
5. Dresser, R. (2006). 'Preimplantation genetic diagnosis as medical innovation: reflections from The President's Council on Bioethics,' Fertility and Sterility, 85, 1633-7.
6. Frankel, M. S. (2003). Inheritable genetic modification and a Brave New World: Did Huxley have it wrong? Hastings Center Report, 33, 31-36.
7. Frankel, M. S., & Chapman, A. R. (2000). 'Human inheritable genetic modifications: assessing scientific, ethical, religious, and policy issues.' Report prepared for the American Association for the Advancement of Science. AAAS. Washington, D.C.
8. Fulka, J. Jr., Miyashita, N., Nagai, T., & Ogura, A. (2004). 'Do cloned mammals skip a reprogramming step?' Nature Biotechnology, 22, 25-26.
9. Jackson, R. A., Gibson, K. A., Wu, Y. W., & Croughan, M. S. (2004). 'Perinatal outcomes in singletons following in vitro fertilization: a A meta-analysis,' Obstetrics and Gynecology, 103, 551-63.
10. Levine, R. (1986). Ethics and Regulation of Clinical Research. New Haven, CT: Yale University Press.
11. United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979). 'The Belmont Report': Ethical Principals and Guidelines for the Protection of Human Subjects of Research. Bethesda, MD: The Commission.
12. National Institutes of Health. Office for Protection from Research Risks (1993). 'Protecting human research subjects: institutional review board guidebook.' Bethesda, MD: OPRR.
13. Parfit, D. (1984). Reasons and Persons. New York: Oxford University Press.
14. Renwick, P. J., Trussler, J., Ostad-Saffari, E., Fassihi, H., Black, C., Braude, P., Ogilvie, C. M., & Abbs, S. (2006). "Proof of principle and first cases using Preimplantation Genetic Haplotyping (PGH) - a paradigm shift for embryo diagnosis." Reproductive Biomedicine Online, 13, 110-9.
15. Resnik, D. B. (2001). 'Human germline gene therapy reconsidered,' Human Gene Therapy, 12, 1449-1458.
16. Resnik, D. B., & R. R. Sharp. (2006). "Protecting third parties in human subjects research." IRB, 28, 1-7.
17. Rideout, W. M., III, Eggan, K., & Jaenisch, R. (2001). 'Nuclear cloning and epigenetic reprogramming of the genome,' Science, 293, 1093-8.
18. Schieve, L. A., Rasmussen, S. A., Buck, G. M., Schendel, D. E., Reynolds, M. A., & Wright, V. C., (2004). 'Are children born after assisted reproductive technology at increased risk for adverse health outcomes?' Obstetrics & Gynecology, 103, 1154-1163.
19. Sutcliffe, A. G. (2002). "Health risks in babies born after assisted reproduction," BMJ, 325, 117-8.
20. Van Voorhis, B. J. (2006). "Outcomes from assisted reproductive technology," Obstetrics and Gynecology, 107, 183-200.
21. World Medical Association. (2000). 'Declaration of Helsinki': WMA.
22. World Medical Association. (2005). 'Protection of human subjects." Code of Federal Regulations Title 45 Part 46.