Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation

Journal of Biological Chemistry

Volumn 286, Issue 2, 2011, Pages 909-918

  Iftikhar, Mussadiq ^a   Hurtado, Paola ^a   Bais, Manish V ^a,b   Wigner, Nate ^b   Stephens, Danielle N ^a   Gerstenfeld, Louis C ^b   Trackman, Philip C ^a  

^a BOSTON UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DEVELOPMENT; BONE FORMATION; CATALYTIC DOMAINS; CHONDROCYTE CELLS; CHONDROCYTE DIFFERENTIATION; CHONDROCYTES; CHONDROGENIC; CHONDROGENIC CELLS; ENDOCHONDRAL BONE DEVELOPMENT; ENZYMATIC CONVERSIONS; FRACTURE HEALING; HYPERTROPHIC CHONDROCYTES; IN-VITRO; IN-VIVO; ISOFORMS; LYSYL OXIDASE; MULTIFUNCTIONAL PROTEIN; NORMAL GROWTH; PROPEPTIDES;

BODY FLUIDS; BONE; CELL CULTURE; ENZYMES; FRACTURE; TRANSCRIPTION FACTORS;

ENZYME ACTIVITY;

LYSYL OXIDASE LIKE 2; OXIDOREDUCTASE; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL GROWTH; CHONDROGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FRACTURE HEALING; HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

AMINO ACID OXIDOREDUCTASES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; FRACTURE HEALING; FRACTURES, BONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; GROWTH PLATE; ISOENZYMES; MALE; MICE; MICE, INBRED C57BL; TRANSCRIPTION FACTORS;

EID: 78651383016     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.155622     Document Type: Article

References (52)

1. Csiszar, K. (2001) Prog. Nucleic Acids Res. Mol. Biol. 70, 1-32
2. Kagan, H. M., and Trackman, P. C. (1991) Am. J. Respir. Cell Mol. Biol. 5, 206-210
3. Selye, H. (1957) Rev. Can. Biol. 16, 1-82
4. Tang, S. S., Trackman, P. C., and Kagan, H. M. (1983) J. Biol. Chem. 258, 4331-4338
5. Min, C., Kirsch, K. H., Zhao, Y., Jeay, S., Palamakumbura, A. H., Trackman, P. C., and Sonenshein, G. E. (2007) Cancer Res. 67, 1105-1112
6. Min, C., Yu, Z., Kirsch, K. H., Zhao, Y., Vora, S. R., Trackman, P. C., Spicer, D. B., Rosenberg, L., Palmer, J. R., and Sonenshein, G. E. (2009) Cancer Res. 69, 6685-6693
7. Palamakumbura, A. H., Jeay, S., Guo, Y., Pischon, N., Sommer, P., Sonenshein, G. E., and Trackman, P. C. (2004) J. Biol. Chem. 279, 40593-40600
8. Palamakumbura, A. H., Vora, S. R., Nugent, M. A., Kirsch, K. H., Sonenshein, G. E., and Trackman, P. C. (2009) Oncogene 28, 3390-3400
9. Vora, S. R., Palamakumbura, A. H., Mitsi, M., Guo, Y., Pischon, N., Nugent, M. A., and Trackman, P. C. (2010) J. Biol. Chem. 285, 7384-7393
10. Vora, S. R., Palamakumbura, A. H., Mitsi, M., Guo, Y., Pischon, N., Nugent, M. A., and Trackman, P. C. (2010) J. Biol. Chem. 285, 2384-2393
11. Wu, M., Min, C., Wang, X., Yu, Z., Kirsch, K. H., Trackman, P. C., and Sonenshein, G. E. (2007) Cancer Res. 67, 6278-6285
12. Hong, H. H., Pischon, N., Santana, R. B., Palamakumbura, A. H., Chase, H. B., Gantz, D., Guo, Y., Uzel, M. I., Ma, D., and Trackman, P. C. (2004) J. Cell. Physiol. 200, 53-62
13. Ito, H., Akiyama, H., Iguchi, H., Iyama, K., Miyamoto, M., Ohsawa, K., and Nakamura, T. (2001) J. Biol. Chem. 276, 24023-24029
14. Gerstenfeld, L. C., Cullinane, D. M., Barnes, G. L., Graves, D. T., and Einhorn, T. A. (2003) J. Cell. Biochem. 88, 873-884
15. Ai-Aql, Z. S., Alagl, A. S., Graves, D. T., Gerstenfeld, L. C., and Einhorn, T. A. (2008) J. Dent. Res. 87, 107-118
16. Bais, M., McLean, J., Sebastiani, P., Young, M., Wigner, N., Smith, T., Kotton, D. N., Einhorn, T. A., and Gerstenfeld, L. C. (2009) PLoS One 4, e5393
17. Jepsen, K. J., Price, C., Silkman, L. J., Nicholls, F. H., Nasser, P., Hu, B., Hadi, N., Alapatt, M., Stapleton, S. N., Kakar, S., Einhorn, T. A., and Gerstenfeld, L. C. (2008) J. Bone Miner. Res. 23, 1204-1216
18. Gerstenfeld, L. C., Alkhiary, Y. M., Krall, E. A., Nicholls, F. H., Stapleton, S. N., Fitch, J. L., Bauer, M., Kayal, R., Graves, D. T., Jepsen, K. J., and Einhorn, T. A. (2006) J. Histochem. Cytochem. 54, 1215-1228
19. Kayal, R. A., Tsatsas, D., Bauer, M. A., Allen, B., Al-Sebaei, M. O., Kakar, S., Leone, C. W., Morgan, E. F., Gerstenfeld, L. C., Einhorn, T. A., and Graves, D. T. (2007) J. Bone Miner Res. 22, 560-568
20. Huggett, J., Dheda, K., Bustin, S., and Zumla, A. (2005) Genes Immun. 6, 279-284
21. Uzel, M. I., Kantarci, A., Hong, H. H., Uygur, C., Sheff, M. C., Firatli, E., and Trackman, P. C. (2001) J. Periodontol. 72, 921-931
22. Hurtado, P. A., Vora, S., Sume, S. S., Yang, D., St Hilaire, C., Guo, Y., Palamakumbura, A. H., Schreiber, B. M., Ravid, K., and Trackman, P. C. (2008) Biochem. Biophys. Res. Commun. 366, 156-161
23. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
24. Bais, M. V., Wigner, N., Young, M., Toholka, R., Graves, D. T., Morgan, E. F., Gerstenfeld, L. C., and Einhorn, T. A. (2009) Bone 45, 254-266
25. Nakatani, S., Mano, H., Im, R., Shimizu, J., and Wada, M. (2007) Biol. Pharm. Bull 30, 433-438
26. Ferguson, C., Alpern, E., Miclau, T., and Helms, J. A. (1999) Mech. Dev. 87, 57-66
27. Atsumi, T., Miwa, Y., Kimata, K., and Ikawa, Y. (1990) Cell Differ. Dev. 30, 109-116
28. Du, Q., Thonberg, H., Wang, J., Wahlestedt, C., and Liang, Z. (2005) Nucleic Acids Res. 33, 1671-1677
29. Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W., and Tuschl, T. (2001) EMBO J. 20, 6877-6888
30. de Frutos, C. A., Vega, S., Manzanares, M., Flores, J. M., Huertas, H., Martínez-Frías, M. L., and Nieto, M. A. (2007) Dev. Cell 13, 872-883
31. Seki, K., Fujimori, T., Savagner, P., Hata, A., Aikawa, T., Ogata, N., Nabeshima, Y., and Kaechoong, L. (2003) J. Biol. Chem. 278, 41862-41870
32. Peinado, H., Del Carmen Iglesias-de la Cruz, M., Olmeda, D., Csiszar, K., Fong, K. S., Vega, S., Nieto, M. A., Cano, A., and Portillo, F. (2005) EMBO J. 24, 3446-3458
33. Hollosi, P., Yakushiji, J. K., Fong, K. S., Csiszar, K., and Fong, S. F. (2009) Int. J. Cancer 125, 318-327
34. Peinado, H., Moreno-Bueno, G., Hardisson, D., Pérez-Gómez, E., Santos, V., Mendiola, M., de Diego, J. I., Nistal, M., Quintanilla, M., Portillo, F., and Cano, A. (2008) Cancer Res. 68, 4541-4550
35. Kagan, H. (1986) in Biology and Regulation of Extracellular Matrix: A Series. Regulation of Matrix Accumulation (Mecham, R. P., ed), pp. 321-398, Academic Press, Orlando
36. Mäki, J. M., Räsänen, J., Tikkanen, H., Sormunen, R., Mäkikallio, K., Kivirikko, K. I., and Soininen, R. (2002) Circulation 106, 2503-2509
37. Lees, S., Eyre, D. R., and Barnard, S. M. (1990) Connect Tissue Res. 24, 95-105
38. Oxlund, H., Barckman, M., Ortoft, G., and Andreassen, T. T. (1995) Bone 17, 365S-371S
39. Williamson, A. K., Chen, A. C., Masuda, K., Thonar, E. J., and Sah, R. L. (2003) J. Orthop. Res. 21, 872-880
40. Williamson, A. K., Masuda, K., Thonar, E. J., and Sah, R. L. (2003) Tissue Eng. 9, 625-634
41. Bank, R. A., Soudry, M., Maroudas, A., Mizrahi, J., and TeKoppele, J. M. (2000) Arthritis Rheum. 43, 2202-2210
42. Basser, P. J., Schneiderman, R., Bank, R. A., Wachtel, E., and Maroudas, A. (1998) Arch. Biochem. Biophys. 351, 207-219
43. Ahsan, T., Lottman, L. M., Harwood, F., Amiel, D., and Sah, R. L. (1999) J. Orthop. Res. 17, 850-857
44. McGowan, K. B., and Sah, R. L. (2005) J. Orthop. Res. 23, 594-601
45. DiMicco, M. A., and Sah, R. L. (2001) J. Orthop. Res. 19, 1105-1112
46. Ford, J. L., Robinson, D. E., and Scammell, B. E. (2004) J. Orthop. Res. 22, 368-375
47. Akiyama, H. (2008) Mod. Rheumatol. 18, 213-219
48. Lucero, H. A., Ravid, K., Grimsby, J. L., Rich, C. B., DiCamillo, S. J., Mäki, J. M., Myllyharju, J., and Kagan, H. M. (2008) J. Biol. Chem. 283, 24103-24117
49. Atsawasuwan, P., Mochida, Y., Katafuchi, M., Kaku, M., Fong, K. S., Csiszar, K., and Yamauchi, M. (2008) J. Biol. Chem. 283, 34229-34240
50. Li, W., Nugent, M. A., Zhao, Y., Chau, A. N., Li, S. J., Chou, I. N., Liu, G., and Kagan, H. M. (2003) J. Cell. Biochem. 88, 152-164
51. Vora, S. R., Guo, Y., Stephens, D. N., Salih, E., Vu, E. D., Kirsch, K. H., Sonenshein, G. E., and Trackman, P. C. (2010) Biochemistry 49, 2962-2972
52. Rodriguez, H. M., Vaysberg, M., Mikels, A., McCauley, S., Velayo, A. C., Garcia, C., and Smith, V. (2010) J. Biol. Chem. 285, 20964-20974