Frequent epigenetic inactivation of Myocardin in human nasopharyngeal carcinoma

Head and Neck

Volumn 33, Issue 1, 2011, Pages 54-59

  Chen, Fu ^a   Mo, Yingxi ^b,c   Ding, Hao ^a   Xiao, Xue ^b   Wang, Shu Yi ^a   Huang, Guangwu ^b   Zhang, Zhe ^b   Wang, Sheng Zi ^a  

^a FUDAN UNIVERSITY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

^c MIE UNIVERSITY   (Japan)

Author keywords

methylation; Myocardin; nasopharyngeal carcinoma

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MYOCARDIN;

ADULT; AGED; ARTICLE; CANCER CELL; DNA METHYLATION; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; ORAL BIOPSY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; CELL LINE, TUMOR; CHI-SQUARE DISTRIBUTION; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; TRANS-ACTIVATORS;

EID: 78651366854     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21396     Document Type: Article

References (16)

1. Wei WI, Sham JS,. Nasopharyngeal carcinoma. Lancet 2005; 365: 2041-2054.
2. Tao Q, Chan AT,. Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments. Expert Rev Mol Med 2007; 9: 1-24.
3. Zhang Z, Sun D, Van do N, Tang A, Hu L, Huang G,. Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Int J Cancer 2007; 120: 32-38.
4. Sun D, Zhang Z, Van DN, Huang G, Ernberg I, Hu L,. Aberrant methylation of CDH13 gene in nasopharyngeal carcinoma could serve as a potential diagnostic biomarker. Oral Oncol 2007; 43: 82-87.
5. Jones PA, Baylin SB,. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-428.
6. Lo KW, Huang DP,. Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002; 12: 451-462.
7. Laird PW,. The power and the promise of DNA methylation markers. Nat Rev Cancer 2003; 3: 253-266.
8. Huang J, Cheng L, Li J, et al. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest 2008; 118: 515-525.
9. Wang D, Chang PS, Wang Z, et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 2001; 105: 851-862.
10. Shats I, Milyavsky M, Cholostoy A, Brosh R, Rotter V,. Myocardin in tumor suppression and myofibroblast differentiation. Cell Cycle 2007; 6: 1141-1146.
11. Doi H, Iso T, Yamazaki M, et al. HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Arterioscler Thromb Vasc Biol 2005; 25: 2328-2334.
12. Milyavsky M, Shats I, Cholostoy A, et al. Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. Cancer Cell 2007; 11: 133-146.
13. Chow N, Bell RD, Deane R, et al. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A 2007; 104: 823-828.
14. Olek A, Oswald J, Walter J,. A modified and improved method for bisulfite based cytosine methylation analysis. Nucleic Acids Res 1996; 24: 5064-5066.
15. Lo KW, Cheung ST, Leung SF, et al. Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 1996; 56: 2721-2725.
16. Lo KW, Huang DP, Lau KM,. p16 gene alterations in nasopharyngeal carcinoma. Cancer Res 1995; 55: 2039-2043.