PH-sensitive polymer hydrogels derived from morpholine to prevent the crystallization of ibuprofen

Journal of Controlled Release

Volumn 149, Issue 2, 2011, Pages 140-145

  Velasco, D ^a   Danoux, Ch B ^b   Redondo, J A ^a   Elvira, C ^a   San Roman J ^a   Wray, P S ^b   Kazarian, S G ^b  

^a INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS   (Spain)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

ATR; Dissolution; Drug delivery; FT IR imaging; Ibuprofen release; Infrared spectroscopy

Indexed keywords

AQUEOUS SOLUBILITY; ATR; ATR FTIR; ATTENUATED TOTAL REFLECTIONS; CARBONYL GROUPS; FT-IR IMAGING; FT-IR-ATR; HOMOPOLYMERS; IBUPROFEN RELEASE; METHACRYLAMIDES; MICRO-DOMAINS; MORPHOLINES; MUCOUS MEMBRANES; N ,N-DIMETHYLACRYLAMIDE; PH SENSITIVE; PH VALUE; PHARMACEUTICAL FORMULATION; RELEASE PROFILES; STRETCHING VIBRATIONS; TRANSDERMAL;

CRYSTALLIZATION; DISSOLUTION; DRUG DELIVERY; HYDROGELS; INFRARED IMAGING; INFRARED SPECTROSCOPY; SOLUBILITY; STRETCHING;

DRUG PRODUCTS;

1,3,5 TRIACRYLOYLHEXAHYDRO 1,3,5 TRIAZINE; IBUPROFEN; MORPHINE; N ETHYLMORPHOLINE METHACRYLAMIDE; N,N DIMETHYLACRYLAMIDE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; CRYSTALLIZATION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; HYDROGEL; INFRARED SPECTROSCOPY; PH; POLYMERIZATION; PRIORITY JOURNAL;

ACRYLAMIDES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROSS-LINKING REAGENTS; CRYSTALLIZATION; HYDROGELS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; MOLECULAR STRUCTURE; MORPHOLINES; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 78651365584     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.10.015     Document Type: Article

References (33)

1. V. Dhikav, S. Singh, and K.S. Anand Newer non-steroidal anti-inflammatory drugs - a review of their therapeutic potential and adverse drug reactions J. Indian academy clinical medicine 3 2002 332 338
2. V.T. Pal'chun, A.I. Kriukov, D.S. Ogorodnikov, A.A. Uzdennikov, N.L. Kunel'skaia, and V.V. Vladimirova On postop strategies in surgically treated forms of ethmoid sinusitis Vestn. Otorinolaringol. 5 1998 21 31
3. M.V. Gavrilin Study of the interaction of ibuprofen with various polymers Phar. Chem. J. 33 1999 604 606
4. M. Halsas, R. Simelius, A. Kiviniemi Effect of different combinations of hydroxypropylmethyl cellulose on bioavailability of ibuprofen from press-coated time-controlled tablets S. T. P. Pharma. Sci. 8 1998 155 161
5. V.V. Boldyrev, T.P. Shakhtshneider, L.P. Burleva, and V.A. Severtsev Preparation of the disperse systems of sulthiazole-polyvinylpyrrolidone by mechanical activation Drug Dev. Ind. Pharm. 20 1994 1103 1114
6. US Patent No. 5,024,997.
7. S.G. Kazarian, and G.G. Martirosyan Spectroscopy of polymer/drug formulations processed with supercritical fluids: in situ ATR-IR and Raman study of impregnation of ibuprofen into PVP Int. J. Pharm. 232 2002 81 90
8. N.A. Peppas, and J. Klier Controlled release by using poly-(methacrylic acid-g-ethylene glycol) hydrogels J. Control. Release 16 1991 203 214
9. V.R. Patel, and M.M. Amiji Preparation and characterization of freeze-dried chitosan-poly (ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach Pharm. Res. 13 1996 588 593
10. H. Ghandehari, P. Kopeckova, and J. Kopecek In vitro degradation of pH-sensitive hydrogels containing aromatic azobonds Biomaterials 18 1997 861 872
11. E.O. Akala, P. Kopeckova, and J. Kopecek Novel pH-sensitive hydrogels with adjustable swelling kinetics Biomaterials 19 1998 1037 1047
12. A. Gutowska, J.S. Bark, I.C. Kwon, Y.H. Bae, and S.W. Kim Squeezing hydrogels for controlled oral drug delivery J. Control. Release 48 1997 141 148
13. H.C. Chiu, G.H. hsiue, Y.P. Lee, and L.W. Huang Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system J. Biomater. Sci. Poly. Ed 10 1999 591 608
14. P. Markland, Y. Zhang, G.L. Amidon, and V.C. Yang A pH- and ionic strength-responsive polypeptide hydrogel: synthesis, characterization, and preliminary protein release studies J. Biomed. Mater. Res. 47 1999 595 602
15. M. Falamarzian, and J. Varshosaz The effect of structural changes on swelling kinetics of polybasic/hydrophobic pH-sensitive hydrogels Drug Dev. Ind. Pharm. 24 1998 667 669 (Pubitemid 28312305)
16. J.H. Kou, G.L. Amidon, and P.I. Lee pH-dependent swelling and solute diffusion characteristics of poly (hydroxyethyl methacrylate-co-methacrylic acid) hydrogels Pharm. Res. 5 1988 592 597
17. L. Brannon-Peppas, and N.A. Peppas Dynamic and equilibrium swelling behavior of pH-sensitive hydrogels containing 2-hydroxyethylmethacrylate Biomaterials 11 1990 635 644
18. A.R. Khare, and N.A. Peppas Release behavior of bioactive agents from pH-sensitive hydrogels J. Biomater. Sci. Poly. Ed 4 1993 275 289
19. R.A. Siegel, M. Falamarzian, B.A. Firestone, and B.C. Moxley pH-controlled release from hydrophobic/polyelectrolyte co-polymer hydrogels J. Control. Release 8 1988 179 182
20. E.N. Lewis, P.J. Treado, R.C. Reeder, G.M. Story, A.E. Dowrey, C. Marcott, and I.W. Levin Fourier transform spectroscopic imaging using an infrared focal-plane array detector Anal. Chem. 67 1995 3377 3381
21. C.M. Snively, S. Katzenberger, G. Oskarsdottir, and J. Lauterbach Fourier-transform infrared imaging using a rapid-scan spectrometer J. Opt. Lett. 24 1999 1841 1843
22. N.J. Harrick Internal Reflection Spectroscopy 1976 Wiley New York
23. S.G. Kazarian, and K.L.A. Chan "Chemical photography" drug release Macromol. 36 2003 9866 9872
24. S.G. Kazarian, and K.L.A. Chan Applications of ATR-FTIR spectroscopic imaging to biomedical samples Biochim. Biophys. Acta 1758 2006 858 867
25. S.G. Kazarian, and J. Van der Weerd Release of poorly soluble drugs from HPMC tablets studied by FTIR imaging and flow-through dissolution tests J. Pharm. Sci. 94 2005 2096 2109
26. S.G. Kazarian, and J. Van der Weerd Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release Pharm. Res. 25 2008 853 860
27. C.S. Colley, S.G. Kazarian, P.D. Weinberg, M. Lever, and J. Spectroscopic Imaging of arteries and atherosclerotic plaques Biopolymers 74 2004 328 335
28. K.L.A. Chan, and S.G. Kazarian High-throughput study of poly(ethylene glycol)/ibuprofen formulations under controlled environment using FTIR imaging J. Comb. Chem. 8 2006 26 31
29. D. Velasco, C. Elvira, and J. San Román New stimuli-responsive polymers derived from morpholine and pyrrolidine J. Mater. Sci. Mater. Med. 19 2008 1453 1458
30. A.S. Sarac Redox polymerization Prog. Polym. Sci. 24 1999 1149 1204
31. E. M. Burka, R. Curbelo, Imaging ATR spectrometer. U.S. Patent 6141100, 2000
32. S.G. Kazarian, and P.S. Wray Application of FTIR spectroscopic imaging in pharmaceutical science S. Sasic, Y. Ozaki, Raman, Infrared and Near-infrared Chemical Imaging 2010 Wiley 185 204
33. B. Vazquez, B. Levenfeld, and J. San Román Role of amine activators on the curing parameters, properties and toxicity of acrylic bone cements Polym. Int. 46 1998 241 250