Relationship between loneliness and proangiogenic cytokines in newly diagnosed tumors of colon and rectum

Psychosomatic Medicine

Volumn 72, Issue 9, 2010, Pages 912-916

  Nausheen, Bina ^a   Carr, Norman J ^b   Peveler, Robert C ^c   Moss Morris, Rona ^a   Verrill, Clare ^b   Robbins, Elizabeth ^b   Nugent, Karen P ^c   Baker, Alex M ^a   Judd, Mary ^a   Gidron, Yori ^d  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Interleukin 6; Loneliness; Social support; Tumor; Vascular endothelial growth factor

Indexed keywords

INTERLEUKIN 6; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER SURGERY; COLON CANCER; CONTROLLED STUDY; EMOTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LONELINESS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUESTIONNAIRE; RECTUM CANCER; SOCIAL SUPPORT;

3,3'-DIAMINOBENZIDINE; ADRENOCORTICOTROPIC HORMONE; AGED; BIOLOGICAL MARKERS; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; LONELINESS; MALE; PROGNOSIS; SEVERITY OF ILLNESS INDEX; SOCIAL SUPPORT; SYMPATHETIC NERVOUS SYSTEM; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78651351225     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3181f0bc1c     Document Type: Article

References (44)

1. Kroenke CH, Kubzansky LD, Schernhammer ES, Holmes MD, Kawachi I. Social network, social support, and survival after breast cancer diagnosis. J Clin Oncol 2006;24:1105-11.
2. Soler-Vila H, Kasl SV, Jones BA. Prognostic significance of psychosocial factors in African-American and white breast cancer patients: a population-based study. Cancer 2003;97:206-13.
3. Garssen B. Psychological factors and cancer development: evidence after 30 years of research. Clin Psychol Rev 2004;24:315-38.
4. Nausheen B, Gidron Y, Peveler R, Moss-Morris R. Social support and cancer progression: a systematic review. J Psychosom Res 2009;67: 403-15.
5. Villingshoj M, Ross L, Thomsen BL, Johansen C. Does marital status and altered contact with the social network predict colorectal cancer survival? Eur J Cancer 2006;42:3022-7.
6. Lehto US, Ojanen M, Dyba T, Aromaa A, Kellokumpu-Lehtinen P. Baseline psychosocial predictors of survival in localised breast cancer. Br J Cancer 2006;94:1245-52.
7. DeVries AC, Glasper ER, Detillion CE. Social modulation of stress responses. Physiol Behav 2003;79:399-407.
8. Lutgendorf SK, Cole S, Costanzo E, Bradley S, Coffin J, Jabbari S, Rainwater K, Ritchie JM, Yang M, Sood AK. Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 2003;9:4514-21.
9. Hawkley LC, Cacioppo JT. Loneliness and pathways to disease. Brain Behav Immun 2003;17(Suppl 1):S98-105.
10. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, Mc-Donald PG, Stefanek M, Sood AK. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006;6:240-8.
11. Thaker PH, Sood AK. Neuroendocrine influences on cancer biology. Semin Cancer Biol 2008;18:164-70.
12. Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 2003;100:2645-50.
13. Nakayama Y, Sako T, Shibao K, Okazaki K, Rempo N, Onitsuka K, Minagawa N, Akahane K, Nagashima N, Nagata N, Itoh H. Prognostic value of plasma vascular endothelial growth factor in patients with colorectal cancer. Anticancer Res 2002;22:2437-42.
14. Feurino LW, Zhang Y, Bharadwaj U, Zhang R, Li F, Fisher WE, Brunicardi FC, Chen C, Yao Q, Min L. IL-6 stimulates Th2 type secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer Biol Ther 2007;6:1096-100.
15. Adachi Y, Aoki C, Yoshio-Hoshino N, Takayama K, Curiel DT, Nishimoto N. Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas. Int J Cancer 2006;119:1303-11.
16. Maes M, Song C, Lin A, De Jongh R, Van Gastel A, Kenis G, Bosmans E, De Meester I, Benoy I, Neels H, Demedts P, Janca A, Scharpé S, Smith RS. The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 1998;10:313-8.
17. Sharma A, Greenman J, Sharp DM, Walker LG, Monson JR. Vascular endothelial growth factor and psychosocial factors in colorectal cancer. Psychooncology 2008;17:66-73.
18. Lutgendorf SK, Johnsen EL, Cooper B, Anderson B, Sorosky JI, Buller RE, Sood AK. Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 2002;95:808-15. (Pubitemid 34839673)
19. Costanzo ES, Lutgendorf SK, Sood AK, Anderson B, Sorosky J, Lubaroff DM. Psychosocial factors and interleukin-6 among women with advanced ovarian cancer. Cancer 2005;104:305-13.
20. Lutgendorf SK, Anderson B, Sorosky JI, Buller RE, Lubaroff DM. Interleukin-6 and use of social support in gynecologic cancer patients. Int J Behav Med 2000;7:127-42.
21. Lutgendorf SK, Lamkin DM, Jennings NB, Arevalo JM, Penedo F, DeGeest K, Langley RR, Lucci JA 3rd, Cole SW, Lubaroff DM, Sood AK. Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma. Clin Cancer Res 2008;14:6839-46.
22. Parkin DM, Bray FI. International patterns of cancer incidence and mortality. In: Schottenfeld D, Fraumeni JF Jr, editors. Cancer Epidemiology and Prevention. 3rd ed. New York: Oxford University Press; 2006.
23. Ell K, Nishimoto R, Mediansky L, Mantell J, Hamovitch M. Social relations, social support and survival among patients with cancer. J Psychosom Res 1992;36:531-41.
24. Goodwin JS, Samet JM, Hunt WC. Determinants of survival in older cancer patients. J Natl Cancer Inst 1996;88:1031-8.
25. Kinney AY, Bloor LE, Dudley WN, Millikan RC, Marshall E, Martin C, Sandler RS. Roles of religious involvement and social support in the risk of colon cancer among Blacks and Whites. Am J Epidemiol 2003;158: 1097-107.
26. de Jong-Gierveld J. Developing and testing a model of loneliness. J Pers Soc Psychol 1987;53:119-28.
27. Russell DW. UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. J Pers Assess 1996;66:20-40.
28. Akerlind I, Hornquist JO, Hansson B. Loneliness correlates in advanced alcohol abusers. I. Social factors and needs. Scand J Soc Med 1987;15: 175-83. (Pubitemid 17091941)
29. Ashizawa T, Okada R, Suzuki Y, Takagi M, Yamazaki T, Sumi T, Aoki T, Aoki T. Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6. Acta Med Okayama 2006;60:325-30.
30. Minagawa N, Nakayama Y, Hirata K, Onitsuka K, Inoue Y, Nagata N, Itoh H. Correlation of plasma level and immunohistochemical expression of vascular endothelial growth factor in patients with advanced colorectal cancer. Anticancer Res 2002;22:2957-63.
31. Nausheen B, Gidron Y, Gregg A, Tissarchondou HS, Peveler R. Loneliness, social support and cardiovascular reactivity to laboratory stress. Stress 2007;10:37-44.
32. Greenwald AG, McGhee DE, Schwartz JL. Measuring individual differences in implicit cognition: the implicit association test. J Pers Soc Psychol 1998;74:1464-80.
33. The Royal College of Pathologists. Dataset for Colorectal Cancer. 2000. Available at http://www.rcpath.org/index.asp?PageID=1153. Accessed May 6, 2009.
34. Kinoshita T, Ito H, Miki C. Serum interleukin-6 level reflects tumor proliferative activity in colorectal cancer patients. Cancer 1999;85:2526-31.
35. Masur K, Niggemann B, Zanker KS, Entschladen F. Norepinephrineinduced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 2001;61:2866-9.
36. Nosek BA, Banaji MR, Greenwald AG. Math = male, me = female, therefore math not = me. J Pers Soc Psychol 2002;83:44-59.
37. Nosek BA. Moderators of the relationship between implicit and explicit evaluation. J Exp Psychol Gen 2002;134:565-84.
38. Fazio RH, Olson MA. Implicit measures in social cognition. research: their meaning and use. Annu Rev Psychol 2003;54:297-327.
39. Greenwald AG, Poehlman TA, Uhlmann EL, Banaji MR. Understanding and using the Implicit Association test: III. Meta-analysis of predictive validity. J Pers Soc Psychol 2009;97:17-41.
40. Carrato A, Gallego-Plazas J, Guillen-Ponce C. Anti-VEGF therapy: a new approach to colorectal cancer therapy. Expert Rev Anticancer Ther 2006;6:1385-96.
41. Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004;4:11-22. (Pubitemid 38111131)
42. Rudge JS, Thurston G, Davis S, Papadopoulos N, Gale N, Wiegand SJ, Yancopoulos GD. VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene-based discovery of the next generation of angiogenesis targets. Cold Spring Harb Symp Quant Biol 2005;70:411-8.
43. Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3:391-400.
44. Hsu JY, Wakelee, HA. Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy. BioDrugs 2009;23:289-304.